Researcher's Profile

Research Area:

Function and regulation of the Hippo pathway

  • SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

    CANCER CELL,1535-6108 ,2018-07-09.
    Fang, L; Teng, HQ; Wang, YL; Liao, GH; Weng, LJ; Li, YX; Wang, XB; Jin, JL; Jiao, CC; Chen, L; Peng, XP; Chen, JY; Yang, YZ; Fang, HQ; Han, DY; Li, C; Jin, XL; Zhang, SL; Liu, ZC; Liu, M; Wei, Q; Liao, LJ; Ge, X; Zhao, B; Zhou, DW; Qin, HL; Zhou, J; Wang, P
    WOS:000438189700010   10.1016/j.ccell.2018.06.002
    Included in : SCIE
  • RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

    NATURE CELL BIOLOGY,1465-7392 ,2018-02.
    Yang, Zhentao; Wang, Yan; Zhang, Yingying; He, Xiadi; Zhong, Chuan-Qi; Nil, Hengxiao; Chen, Xin; Liang, Yaoji; Wu, Jianfeng; Zhao, Shimin; Zhou, Dawang; Han, Jiahuai
    WOS:000423433800012   10.1038/s41556-017-0022-y
    Included in : SCIE
  • Pd nanosheets with their surface coordinated by radioactive iodide as a high-performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy

    Chemical Science,2041-6520 ,2018.
    Chen, Mei(1,2); Guo, Zhide(3); Chen, Qinghua(4); Wei, Jingping(1); Li, Jingchao(1); Shi, Changrong(3); Xu, Duo(3); Zhou, Dawang(4); Zhang, Xianzhong(3); Zheng, Nanfeng(1)
    WOS:000432203100009   EI:20182005203749   10.1039/c8sc00104a
    Included in : SCIE、EI
  • The transcriptional coactivator TAZ regulates reciprocal differentiation of T(H)17 cells and T-reg cells

    NATURE IMMUNOLOGY,1529-2908 ,2017-07.
    Geng, Jing; Yu, Shujuan; Zhao, Hao; Sun, Xiufeng; Li, Xun; Wang, Ping; Xiong, Xiaolin; Hong, Lixin; Xie, Changchuan; Gao, Jiahui; Shi, Yiran; Peng, Jiaqi; Johnson, Randy L.; Xiao, Nengming; Lu, Linrong; Han, Jiahuai; Zhou, Dawang; Chen, Lanfen
    WOS:000403676300015   10.1038/ni.3748
    Included in : SCIE
  • Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

    CANCER CELL,1535-6108 ,2017-05-08.
    Zhang, Shihao; Chen, Qinghua; Liu, Qingxu; Li, Yuxi; Sun, Xiufeng; Hong, Lixin; Ji, Suyuan; Liu, Chengyan; Geng, Jing; Zhang, Weiji; Lu, Zhonglei; Yin, Zhen-Yu; Zeng, Yuanyuan; Lin, Kwang-Huei; Wu, Qiao; Li, Qiyuan; Nakayama, Keiko; Nakayama, Keiich I.; Deng, Xianming; Johnson, Randy L.; Zhu, Liang; Gao, Daming; Chen, Lanfen; Zhou, Dawang
    WOS:000400738600010   10.1016/j.ccell.2017.04.004
    Included in : SCIE
  • Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors

    CANCER RESEARCH,0008-5472 ,2017-01-01.
    Jiang, Jie; Gui, Fu; He, Zhixiang; Li, Li; Li, Yunzhan; Li, Shunying; Wu, Xinrui; Deng, Zhou; Sun, Xihuan; Huang, Xiaoxing; Huang, Wei; Han, Shang; Zhang, Ting; Wang, Zheng; Jiao, Bo; Song, Siyang; Wang, Hongrui; Chen, Lanfen; Zhou, Dawang; Liu, Qiang; Ren, Ruibao; Zhang, Jianming; Deng, Xianming
    WOS:000393187900016   10.1158/0008-5472.CAN-16-1038
    Included in : SCIE
  • Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

    Advanced Materials,0935-9648 ,2017.
    Liu, Zehua(1); Li, Yunzhan(2,3); Li, Wei(1); Xiao, Chen(2,3); Liu, Dongfei(1,8); Dong, Chao(2,3); Zhang, Ming(2,3); M?kil?, Ermei(4); Kemell, Marianna(5); Salonen, Jarno(4); Hirvonen, Jouni T.(1); Zhang, Hongbo(6,7); Zhou, Dawang(2,3); Deng, Xianming(2,3); Santos, Hélder A.(1,8)
    WOS:000436455800001   EI:20174204274704   10.1002/adma.201703393
    Included in : SCIE、EI
  • Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

    SCIENCE TRANSLATIONAL MEDICINE,1946-6234 ,2016-08-17.
    Fan, Fuqin; He, Zhixiang; Kong, Lu-Lu; Chen, Qinghua; Yuan, Quan; Zhang, Shihao; Ye, Jinjin; Liu, Hao; Sun, Xiufeng; Geng, Jing; Yuan, Lunzhi; Hong, Lixin; Xiao, Chen; Zhang, Weiji; Sun, Xihuan; Li, Yunzhan; Wang, Ping; Huang, Lihong; Wu, Xinrui; Ji, Zhiliang; Wu, Qiao; Xia, Ning-Shao; Gray, Nathanael S.; Chen, Lanfen; Yun, Cai-Hong; Deng, Xianming; Zhou, Dawang
    WOS:000384013700002   10.1126/scitranslmed.aaf2304
    Included in : SCIE
  • Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

    NATURE IMMUNOLOGY,1529-2908 ,2015-11.
    Geng, Jing; Sun, Xiufeng; Wang, Ping; Zhang, Shihao; Wang, Xiaozhen; Wu, Hongtan; Hong, Lixin; Xie, Changchuan; Li, Xun; Zhao, Hao; Liu, Qingxu; Jiang, Mingting; Chen, Qinghua; Zhang, Jinjia; Li, Yang; Song, Siyang; Wang, Hong-Rui; Zhou, Rongbin; Johnson, Randy L.; Chien, Kun-Yi; Lin, Sheng-Cai; Han, Jiahuai; Avruch, Joseph; Chen, Lanfen; Zhou, Dawang
    WOS:000363096000008   10.1038/ni.3268
    Included in : SCIE
  • The kinases NDR1/2 act downstream of the Hippo homolog MST1 tomediate both egress of thymocytes from the thymus and lymphocyte motility

    SCIENCE SIGNALING,1945-0877 ,2015-10-06.
    Tang, Fengyuan; Gill, Jason; Ficht, Xenia; Barthlott, Thomas; Cornils, Hauke; Schmitz-Rohmer, Debora; Hynx, Debby; Zhou, Dawang; Zhang, Lei; Xue, Gongda; Grzmil, Michal; Yang, Zhongzhou; Hergovich, Alexander; Hollaender, Georg A.; Stein, Jens V.; Hemmings, Brian A.; Matthias, Patrick
    WOS:000363319100003   10.1126/scisignal.aab2425
    Included in : SCIE
  • A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis

    CELL RESEARCH,1001-0602 ,2015-09.
    Shen, Shuying; Guo, Xiaocan; Yan, Huan; Lu, Yi; Ji, Xinyan; Li, Li; Liang, Tingbo; Zhou, Dawang; Feng, Xin-Hua; Zhao, Jonathan C.; Yu, Jindan; Gong, Xing-Guo; Zhang, Lei; Zhao, Bin
    WOS:000360765600005   10.1038/cr.2015.98
    Included in : SCIE
  • Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment

    CELL DEATH & DISEASE,2041-4889 ,2014-05.
    Matsumoto, H.; Murakami, Y.; Kataoka, K.; Lin, H.; Connor, K. M.; Miller, J. W.; Zhou, D.; Avruch, J.; Vavvas, D. G.
    WOS:000337229300069   10.1038/cddis.2014.218
    Included in : SCIE
  • Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

    CELL REPORTS,2211-1247 ,2014-05.
    Zeng, Taoling; Wang, Qun; Fu, Jieying; Lin, Qi; Bi, Jing; Ding, Weichao; Qiao, Yikai; Zhang, Sheng; Zhao, Wenxiu; Lin, Huayue; Wang, Meilin; Lu, Binfeng; Deng, Xianming; Zhou, Dawang; Yin, Zhenyu; Wang, Hong-Rui
    WOS:000335560900027   10.1016/j.celrep.2014.03.045
    Included in : SCIE
  • Ubiquitin E3 ligase CRL4CDT2/DCAF2 as a potential chemotherapeutic target for ovarian surface epithelial cancer

    Journal of Biological Chemistry,0021-9258 ,2013-10-11.
    Pan, Wei-Wei(1,2,4); Zhou, Jian-Jie(3); Yu, Chao(1); Xu, Ying(4); Guo, Lian-Jun(4); Zhang, Hai-Yi(1); Zhou, Dawang(3); Song, Fang-Zhou(2); Fan, Heng-Yu(1)
    WOS:000330615300043   EI:20134316878495   10.1074/jbc.M113.495069
    Included in : SCIE、EI
  • Mst1 and Mst2 kinases: regulations and diseases

    CELL AND BIOSCIENCE,2045-3701 ,2013-08-28.
    Qin, Funiu; Tian, Jing; Zhou, Dawang; Chen, Lanfen
    WOS:000325165700001   10.1186/2045-3701-3-31
    Included in : SCIE
  • DNA Topoisomerase II Is Dispensable for Oocyte Meiotic Resumption but Is Essential for Meiotic Chromosome Condensation and Separation in Mice

    BIOLOGY OF REPRODUCTION,0006-3363 ,2013.
    Li, Xiao-Meng; Yu, Chao; Wang, Zhong-Wei; Zhang, Yin-Li; Liu, Xiao-Man; Zhou, Dawang; Sun, Qing-Yuan; Fan, Heng-Yu
    WOS:000328274300002   10.1095/biolreprod.113.110692
    Included in : SCIE
  • Protein kinases of the Hippo pathway: Regulation and substrates

    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY,1084-9521 ,2012-09.
    Avruch, Joseph; Zhou, Dawang; Fitamant, Julien; Bardeesy, Nabeel; Mou, Fan; Barrufet, Laura Regue
    WOS:000309264300008   10.1016/j.semcdb.2012.07.002
    Included in : SCIE
  • Hippo pathway in intestinal homeostasis and tumorigenesis

    PROTEIN & CELL,1674-800X ,2012-04.
    Chen, Lanfen; Qin, Funiu; Deng, Xianming; Avruch, Joseph; Zhou, Dawang
    WOS:000310527600008   10.1007/s13238-012-2913-9
    Included in : SCIE
  • YAP oncogene overexpression supercharges colon cancer proliferation

    CELL CYCLE,1538-4101 ,2012-03-15.
    Avruch, Joseph; Zhou, Dawang; Bardeesy, Nabeel
    WOS:000301851700013   10.4161/cc.11.6.19453
    Included in : SCIE
  • Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,0027-8424 ,2011-12-06.
    Zhou, Dawang; Zhang, Yongyou; Wu, Hongtan; Barry, Evan; Yin, Yi; Lawrence, Earl; Dawson, Dawn; Willis, Joseph E.; Markowitz, Sanford D.; Camargo, Fernando D.; Avruch, Joseph
    WOS:000297683800008   10.1073/pnas.1110428108
    Included in : SCIE
  • Hippo信号通路与肝脏稳态调控及疾病发生

    遗传,0253-9772 ,2017-07-20.
    李玉席;李俊宏;周大旺
    CSCD核心
  • Hippo信号通路:器官大小与组织稳态调控器

    遗传,0253-9772 ,2017.
    张雷;袁增强;周大旺;赵斌
    CSCD核心
  • Hippo信号通路调控宿主抗感染的重要防御机制

    中国科学基金,1000-8217 ,2016-01-15.
    耿晶;孙秀峰;王平;王晓珍;张世浩;赵昊;熊晓琳;陈兰芬;周大旺
    CSCD扩展 理工二类核心
  • 遵循人才培养规律的生物科学专业课程体系建设探讨

    高校生物学教学研究(电子版),2095-1574 ,2016-09-15.
    王勤;李勤喜;郑毅芳;田静;左正宏;宋思扬;林圣彩;周大旺
  • 生物化学实验课教学改革及本科生基本科研素质培养

    教育教学论坛,1674-9324 ,2016-08-17.
    石艳;王勤;徐庆妍;柯莉娜;周大旺