Researcher's Profile

Research Area:

Chemical biology and medicinal chemistry

  • Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis

    MOLECULAR PHARMACEUTICS,1543-8384 ,2016-11.
    Huang, Xiaoxing; Huang, Wei; Li, Li; Sun, Xihuan; Song, Siyang; Xu, Qingyan; Zhang, Lianru; Wei, Bang-Guo; Deng, Xianming
    WOS:000387428300015   10.1021/acs.molpharmaceut.6b00564
    Included in : SCIE
  • Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition

    SCIENCE SIGNALING,1945-0877 ,2016-10-18.
    Zhang, Jinwei; Deng, Xianming; Kahle, Kristopher T.
    WOS:000387029300003   10.1126/scisignal.aaj2227
    Included in : SCIE
  • Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-delta/gamma Inhibitors

    Ferguson, Fleur M.; Ni, Jing; Zhang, Tinghu; Tesar, Bethany; Sim, Taebo; Kim, Nam Doo; Deng, Xianming; Brown, Jennifer R.; Zhao, Jean J.; Gray, Nathanael S.
    WOS:000385689300009   10.1021/acsmedchemlett.6b00209
    Included in : SCIE
  • Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

    SCIENCE TRANSLATIONAL MEDICINE,1946-6234 ,2016-08-17.
    Fan, Fuqin; He, Zhixiang; Kong, Lu-Lu; Chen, Qinghua; Yuan, Quan; Zhang, Shihao; Ye, Jinjin; Liu, Hao; Sun, Xiufeng; Geng, Jing; Yuan, Lunzhi; Hong, Lixin; Xiao, Chen; Zhang, Weiji; Sun, Xihuan; Li, Yunzhan; Wang, Ping; Huang, Lihong; Wu, Xinrui; Ji, Zhiliang; Wu, Qiao; Xia, Ning-Shao; Gray, Nathanael S.; Chen, Lanfen; Yun, Cai-Hong; Deng, Xianming; Zhou, Dawang
    WOS:000384013700002   10.1126/scitranslmed.aaf2304
    Included in : SCIE
  • Direct Targeting of beta-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/beta-Catenin Signaling

    CELL REPORTS,2211-1247 ,2016-06-28.
    Hwang, So-Young; Deng, Xianming; Byun, Sanguine; Lee, Chan; Lee, Seung-Joo; Suh, Hyunsuk; Zhang, Jianming; Kang, Qiaofeng; Zhang, Ting; Westover, Kenneth D.; Mandinova, Anna; Lee, Sam W.
    WOS:000378950700004   10.1016/j.celrep.2016.05.071
    Included in : SCIE
  • Two New Ring A-Cleaved Lanostane-Type Triterpenoids and Four Known Steroids Isolated from Endophytic Fungus Glomerella sp. F00244

    Helvetica Chimica Acta,0018-019X ,2016.
    Guo, Kai(1,2,3); Fang, Huiqin(1,2); Gui, Fu(1,2); Wang, Yuezhou(1,2); Xu, Qinyan(1,2); Deng, Xianming(1,2)
    WOS:000383473800005   EI:20163202682330   10.1002/hlca.201600039
    Included in : SCIE、EI
  • 福建省药理学学科发展报告

    海峡科学,1673-8683 ,2016-01-15.