Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms

Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens

Paspalines C-D and Paxillines B-D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69

Atomic resolution Cryo-EM structure of human proteasome activator PA28?

Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system

HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC

H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform

PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron

NF-kappa B Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice

Role of SPAK-NKCC1 signaling cascade in the choroid plexus blood-CSF barrier damage after stroke

Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations

Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process

An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Pharmacological targeting PIKfyve and tubulin as an effective treatment strategy for double-hit lymphoma

A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC