Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors

Design, synthesis, and biological evaluation of novel 4,4′-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer

Discovery of new DHA ethanolamine derivatives as potential anti-inflammatory agents targeting Nur77

Discovery of 5-(Pyrimidin-2-ylamino)-1<i>H</i>-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer

Design, synthesis, and biological evaluation of carbonyl-hydrazine-1-carboxamide derivatives as anti-hepatic fibrosis agents targeting Nur77

Screening of small molecule compounds targeting hnRNPA2 protein

The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma

Identification and characterization of 7-azaindole derivatives as inhibitors of the SARS-CoV-2 spike-hACE2 protein interaction

Inhibition of Nur77 expression and translocation by compound B6 reduces ER stress and alleviates cigarette smoke-induced inflammation and injury in bronchial epithelial cells

Discovery of bipyridine amide derivatives targeting pRXR?-PLK1 interaction for anticancer therapy

The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9

Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the <i>in vivo</i> anti-obesity effect of the DPA-EA and DHA-EA mixture prepared from algae oil

Identification of potential ATP-competitive cyclin-dependent kinase 1 inhibitors: De novo drug generation, molecular docking, and molecular dynamics simulation

Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling

Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77

Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors

Design, synthesis, and biological evaluation of (E)-N0-substitute-4-((4-pyridylpyrimidin-2-yl)amino) benzohydrazide derivatives as novel potential CDK9 inhibitors

AI-Aided Design of Novel Targeted Covalent Inhibitors against SARS-CoV-2

Study on Salicylanilide Analogue for Antioxidant Activity and Melanosis Prevention in Chinese White Shrimp (Fenneropenaeus chinensis)

Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma

Anti-inflammatory sesquiterpenoids from the heartwood of Juniperus formosana Hayata

Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo

Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1/AMPK/ PPAR alpha pathway via targeting nicotinamide N-methyltransferase

New cyclopentenoneacrylic acid derivatives from a marine-derived fungus Trichoderma atroviride H548

Discovery of new chalone adamantyl arotinoids having RXR alpha-modulating and anticancer activities

Synthesis, SAR study, and bioactivity evaluation of a series of Quinoline-Indole-Schiff base derivatives: Compound 10E as a new Nur77 exporter and autophagic death inducer

Prevention of quality loss and melanosis of white leg shrimp by Sargassum horneri extracts

Novel derivatives of salicylanilide: Synthesis, characterization, PPO inhibitory activity and cytotoxicity

Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent

Synthesis and discovery of omega-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77

Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators

Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors

Glycine metabolomic changes induced by anticancer agents in A549 cells

Synthesis and biological evaluations of N '-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents

A self-attention based message passing neural network for predicting molecular lipophilicity and aqueous solubility

Synthesis, biological activities, and docking studies of D-pantolactone derivatives as novel FAS inhibitors

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

Synthesis and Biological Activity Research of 4-Substitued-1-(2-methyl-6-(pyridin-3-yl)-nicotinoyl) Semicarbazides

Iodide-Catalyzed Phosphorothiolation of Heteroarenes Using P(O)H Compounds and Elemental Sulfur

New beta-Lactone with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus MCCC3A00957

Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus

Insights into the stereoselectivity of human SETD7 methyltransferase

Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

Moringa oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPAR alpha

Cobalt-Catalyzed Oxidative C(sp(3))-H Phosphonylation for alpha-Aminophosphonates via C(sp(3))-H/P(O)-H Coupling

Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

The effect of V155M mutation on the complex of hSTING and 2'3'-cGAMP: an in silico study case

Development of an on-line mixed-mode gel liquid chromatography×reversed phase liquid chromatography method for separation of water extract from Flos Carthami

Synthesis and biological evaluation of 1-(2-(adamantane-1-yl)-1H-indol-5-yl)-3-substituted urea/thiourea derivatives as anticancer agents

The molecular mechanism of hPPARα activation

Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment

Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression

Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents

Comprehensive two-dimensional normal-phase liquid chromatography × reversed-phase liquid chromatography for analysis of toad skin

New on-line separation workflow of microbial metabolites via hyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography

Biosynthetic Functional Gene Analysis of Bis-Indole Metabolites from 25D7, a Clone Derived from a Deep-Sea Sediment Metagenomic Library

A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5

Distinguishing isomeric aldohexose-ketohexose disaccharides by electrospray ionization mass spectrometry in positive mode

On-line two-dimensional countercurrent chromatography × high performance liquid chromatography system with a novel fragmentary dilution and turbulent mixing interface for preparation of coumarins from Cnidium monnieri

Online polar two phase countercurrent chromatographyhigh performance liquid chromatography for preparative isolation of polar polyphenols from tea extract in a single step

On-line comprehensive two-dimensional normal-phase liquid chromatographyreversed-phase liquid chromatography for preparative isolation of Peucedanum praeruptorum

Two-dimensional countercurrent chromatography×high performance liquid chromatography with heart-cutting and stop-and-go techniques for preparative isolation of coumarin derivatives from Peucedanum praeruptorum Dunn

Using positive-ion electrospray ionization mass spectrometry and H/D exchange study phosphoryl group transfer reactions involved in amino acid ester isopropyl phosphoramidates of Brefeldin A

Two-dimensional preparative liquid chromatography system for preparative separation of minor amount components from complicated natural products

Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

Two-dimensional countercurrent chromatography x high performance liquid chromatography for preparative isolation of toad venom

A new diphenyl ether from Phoma sp strain, SHZK-2

Copper-Catalyzed C-P Bond Construction via Direct Coupling of Phenylboronic Acids with H-Phosphonate Diesters

COPPER (I) IODIDE-CATALYZED SOLVENT-FREE SYNTHESIS OF alpha-AMINOPHOSPHONATES

Synthesis, Crystal Structure and Fragmentation Pathway of Arylcarboxy Ester of alpha-Hydroxyphosphonate

Benzyl N-(4-pyridyl)carbamate

Electrospray ionization tandem mass spectrometry of phosphonate peptides

Synthesis, Characterizations, and Crystal Structures of -Hydroxyphosphonic Acid Esters

Synthesis and crystal structure of diisopropyl hydroxy(4-methoxyphenyl)methylphosphonate

Methyl 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxybenzoate

Syntheses, characterizations, and crystal structures of phosphonopeptides