英文论文
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文献类型
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Article
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题名
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Mepanipyrim induces cardiotoxicity of zebrafish (Danio rerio) larvae via promoting AhR-regulated COX expression pathway
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作者
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Shen, Chao; He, Jing; Zhu, Kongyang; Zheng, Naying; Yu, Yue; He, Chengyong; Yang, Chunyan; Zuo, Zhenghong
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作者单位
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[Shen, Chao; He, Jing; Zhu, Kongyang; Zheng, Naying; Yu, Yue; He, Chengyong; Yang, Chunyan; Zuo, Zhenghong] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China. [Zuo, Zhenghong] Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Peoples R China.
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通讯作者地址
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Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China.; Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Peoples R China.
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Email
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yangchuanyan@xmu.edu.cn; zuozhenghong@xmu.edu.cn
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ResearchID
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ORCID
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期刊名称
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JOURNAL OF ENVIRONMENTAL SCIENCES
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出版社
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SCIENCE PRESS
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ISSN
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1001-0742
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出版信息
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2023-03, 125:650-661.
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JCR
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影响因子
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ISBN
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基金
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National Natural Science Foundation of China [42177411, 31971234]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Zebrafish ( Danio rerio ); Mepanipyrim; AhR agonist; Cardiotoxicity; CH223191; Cytochrome coxidase
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摘要
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The wide use of pesticides has seriously threatened human health and the survival of beneficial organisms. The fungicide mepanipyrim is widely used in viticulture practices. Studies of mepanipyrim-induced toxicity in organisms are still scarce, especially studies on cardiotoxicity. In this study, we aimed to investigate mepanipyrim-induced cardiotoxicity in zebrafish ( Danio rerio ) larvae. We found that mepanipyrim could induce cardiotoxicity by altering the heart rate and cardiomyocyte diameter of larvae. Meanwhile, RNA sequencing and RT-qPCR data indicated that mepanipyrim exposure could dramatically alter the mRNA expression of calcium signaling pathway-, cardiac muscle contraction-, and oxidative respiratory chain-related genes. Interestingly, by the CALUX cell bioassay, we found that most cytochrome c oxidase (COX) family genes exhibited potential AhR-regulated activity, suggesting that mepanipyrim induced cardiotoxicity via a novel AhR-regulated manner in larvae. Additionally, the AhR antagonist CH223191 could effectively prevent mepanipyrim-induced cardiotoxicity in zebrafish larvae. In conclusion, the AhR agonist mepanipyrim could induce cardiotoxicity in a novel unreported AhR-regulated manner, which could specifically affect the expression of COX family genes involved in the mitochondrial oxidative respiratory chain. Our data will help explain the toxic effects of mepanipyrim on organisms and provide new insight into the AhR agonistic activity pesticide-induced cardiotoxicity. ?? 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
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一级学科
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Environmental Sciences
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WOS入藏号
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WOS:000798959500011
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EI收录号
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DOI
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10.1016/j.jes.2022.01.0121001-0742
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ESI
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收录于
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SCIE
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