英文论文
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文献类型
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Article
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题名
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NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice
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作者
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Huang, Feng; Zhang, Tong; Li, Bin; Wang, Shaosong; Xu, Chang; Huang, Caihua; Lin, Donghai
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作者单位
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[Huang, Feng; Li, Bin; Wang, Shaosong] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China. [Zhang, Tong; Lin, Donghai] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, MOE Key Lab Spectrochem Anal & Instrumentat, Xiamen 361005, Peoples R China. [Huang, Feng] China Acad Chinese Med Sci, Acupuncture & Moxibust, Beijing 100700, Peoples R China. [Zhang, Tong] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China. [Huang, Caihua] Xiamen Univ Technol, Res & Commun Ctr Exercise & Hlth, Xiamen 361024, Peoples R China. [Xu, Chang] Capital Med Univ, Beijing Shijitan Hosp, Beijing 100038, Peoples R China. [Lin, Donghai] Xiamen Univ, Coll Chem & Chem Engn, High Field NMR Ctr, Xiamen 361005, Peoples R China.
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通讯作者地址
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Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China.; Xiamen Univ, Coll Chem & Chem Engn, High Field NMR Ctr, Xiamen 361005, Peoples R China.
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Email
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hf2061043@163.com; dhlin@xmu.edu.cn
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ResearchID
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ORCID
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期刊名称
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JOURNAL OF ETHNOPHARMACOLOGY
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出版社
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ELSEVIER IRELAND LTD
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ISSN
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0378-8741
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出版信息
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2023-01-10, 300
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JCR
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影响因子
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ISBN
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基金
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National Natural Science Foundation of China [81503580, 31971357]; Beijing Municipal Administration of Hospital ? [QML20171002]; Scientific Research Common Program of Beijing Municipal Commission of Education [KM201710025023]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Moxibustion; Imiquimod-induced psoriatic mice; NMR; Metabolomics
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摘要
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Ethnopharmacological relevance: Moxibustion is a traditional medical intervention of traditional Chinese medi-cine. It refers to the direct or indirect application of ignited moxa wool made of mugwort leaves to acupuncture points or other specific parts of the body for either treating or preventing diseases. Moxibustion has been proven to be effective in treating skin lesions of psoriasis.Aim of the study: This study was performed to elucidate molecular mechanisms underlying the effects of moxi-bustion treatment on imiquimod-induced psoriatic mice.Materials and methods: We established an imiquimod (IMQ)-induced psoriatic mice (Model) and assessed the effects of moxibustion (Moxi) treatment on skin lesions of psoriatic mice by the PASI scores and expressions of inflammation-related factors relative to normal control mice (NC). We then performed nuclear magnetic reso-nance (NMR)-based metabolomic analysis on the skin tissues of the NC, Model and Moxi-treated mice to address metabolic differences among the three groups.Results: Moxi mice showed reduced PASI scores and decreased expressions of the pro-inflammatory cytokines IL -8, IL-17A and IL-23 relative to Model mice. Compared with the Model group, the NC and Moxi groups shared 9 characteristic metabolites and 4 significantly altered metabolic pathways except for taurine and hypotaurine metabolism uniquely identified in the NC group. To a certain extent, moxibustion treatment improved metabolic disorders of skin lesions of psoriatic mice by decreasing glucose, valine, asparagine, aspartate and alanine-mediated cell proliferation and synthesis of scaffold proteins, alleviating histidine-mediated hyperproliferation of blood vessels, and promoting triacylglycerol decomposition.Conclusions: This study reveals the molecular mechanisms underlying the effects of moxibustion treatment on the skin lesions of psoriasis, potentially improving the clinical efficacy of moxibustion.
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一级学科
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Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
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WOS入藏号
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WOS:000858404600002
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EI收录号
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DOI
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10.1016/j.jep.2022.115626
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ESI
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收录于
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SCIE
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