Articles


Document Type
Journal article (JA)
Title
Exposure to environmental level phenanthrene induces a NASH-like phenotype in new born rat
Author
Guo, Jiaojiao(1); Wang, Chonggang(1,2); Guo, Zhizhun(1); Zuo, Zhenghong(1,2)
Address
(1) State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen; 361005, China; (2) State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen; 361005, China
RPAddress
Email
ResearchID
ORCID
Journal
Environmental Pollution
Publisher
Elsevier Ltd
ISSN
0269-7491
Published
2018-08, 239:261-271.
JCR
ImpactFactor
ISBN
Fund_Code
HYMC
HYDD
HYKSRQ
HYJSRQ
HYLWLB
HYJB
Keywords
Anthracene - Cardiovascular system - Cytology - Enzyme inhibition - Histology - Oxidative stress - Rats - Toxicity
Abstract
More and more evidence indicates that persistent organic pollutants (POPs) are a risk factor for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Phenanthrene (Phe) is a kind of POP which existed extensively in the environment, but whose toxicity on mammals has so far received less focus. Subcutaneously injection of Phe (0.5, 5, 50 μg/kg) for 21 days induced significant NAFLD/NASH symptoms in new born rats. Exposure to environmental levels of Phe decreased body weight and liver-somatic index; impaired histology of liver; influenced the peroxisome proliferator-activated receptor gamma (PPARγ) signaling and lipid metabolism in liver; stimulated oxidative stress in the rats' liver; induced the variation of NFκB pathway and liver inflammatory response; and caused liver fibrosis via transforming growth factor β1 (tgfβ1). We speculated that the subcutaneously injected Phe was transferred to the liver through blood circulation, which may have induced the elevation of PPARγ directly or indirectly, leading to liver steatosis. Excess lipid, acting as the first hit, stimulated the second hit factors - oxidative stress, inflammatory response and lipid peroxidation, and finally resulted in steatohepatitis and liver fibrosis. Exposure to environmental level phenanthrene impaired histology, induced inflammatory response and caused fibrosis in the liver of new born rat. ? 2018 Elsevier Ltd
WOS Categories
Accession Number
EI收录号
20181605027935
DOI
10.1016/j.envpol.2018.04.030
ESI_Type
ENVIRONMENT/ECOLOGY
Collection
EI

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