Articles


Document Type
Journal article (JA)
Title
MicroSPECT imaging of triple negative breast cancer cell tumor xenografted in athymic mice with radioiodinated anti-ICAM-1 monoclonal antibody
Author
You, Linyi(1); Wang, Xiangyu(1); Guo, Zhide(1); Zhang, Deliang(1); Zhang, Pu(1); Li, Jindian(1); Su, Xinhui(2); Pan, Weimin(3); Zhang, Xianzhong(1)
Address
(1) State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiang'An South Rd, Xiamen; 361102, China; (2) Department of Nuclear Medicine, Zhongshan Hospital Affiliated of Xiamen University, Hubin South Road, Xiamen; 361004, China; (3) Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical University, 31 Longhua Rd, Haikou; 570102, China
RPAddress
Email
ResearchID
ORCID
Journal
Applied Radiation and Isotopes
Publisher
Elsevier Ltd
ISSN
0969-8043
Published
2018-09, 139:20-25.
JCR
ImpactFactor
ISBN
Fund_Code
HYMC
HYDD
HYKSRQ
HYJSRQ
HYLWLB
HYJB
Keywords
Cell adhesion - Diagnosis - Diseases - Mammals - Monoclonal antibodies - Single photon emission computed tomography - Tumors
Abstract
Intercellular adhesion molecule-1(ICAM-1) is a potential molecular target and biomarker for triple negative breast cancer (TNBC) therapy and diagnosis. In this study, aICAM-1 was radioiodinated with125I/131I in high radiochemical yield and the probes for TNBC tumor targeting and radioimmunotherapy were evaluated in tumor-bearing mice. High and specific accumulation of125I-aICAM1 in TNBC MDA-MB-231 tumor was observed in SPECT imaging and the tumor grew was inhibited obviously by131I-aICAM1. Thus, the radioiodinated aICAM1 could serve as potential agents for TNBC theranostics. ? 2018 Elsevier Ltd
WOS Categories
Accession Number
EI收录号
20181705046105
DOI
10.1016/j.apradiso.2018.04.005
ESI_Type
PHYSICS
Collection
EI

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