英文论文


文献类型
Journal article (JA)
题名
Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells
作者
Xu, Weixia (1); Ge, Pengjin (1); Niu, Boning (1); Zhang, Xiaokun (1); Liu, Jie (1); Xie, Jingjing (1)
作者单位
(1) School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiang'an South Road, Xiamen; Fujian; 361102, China
通讯作者地址
Xiamen Univ, Sch Pharmaceut Sci, Xiangan South Rd, Xiamen 361102, Fujian, Peoples R China.; Xie, JJ (reprint author), Xiamen Univ, Fujian Prov Key Lab Innovat Drug Target Res, Xiangan South Rd, Xiamen 361102, Fujian, Peoples R China.
Email
ResearchID
ORCID
期刊名称
Journal of Colloid and Interface Science
出版社
Academic Press Inc.
ISSN
0021-9797
出版信息
2018-10-01, 527:141-150.
JCR
2
影响因子
6.361
ISBN
基金
National Natural Science Foundation of China [81702988, U1405229, 81672749, 91429306, 81502406]; Natural Science Foundation of Fujian Province of China [2017J05137]; Fundamental Research Funds for the Central Universities [20720160061]; Regional Demonstration of Marine Economy Innovative Development Project [14PYY051SF04, 16PYY007SF17]; Fujian Provincial Science & Technology Department [2017YZ0002-1]; XMU Training Program of Innovation and Enterpreneurship for Undergraduates [2016Y0718, 2017X0512]
会议名称
会议地点
会议开始日期
会议结束日期
关键词
Cell death; Controlled drug delivery; Diseases; Peptides; Pore size; Silica nanoparticles; Targeted drug delivery
摘要
The abundance of B cell lymphoma gene 2 (Bcl-2) is closely correlated with the resistance of cancer cells to chemotherapeutic agents, and a peptide derived from orphan nuclear receptor Nur77 can convert Bcl-2 from a protector to a killer of cancer cells. However, successful application of the Bcl-2-converting peptide to treat drug-resistant cancer cells depends on an efficient delivery carrier. Mesoporous silica nanoparticles (MSNs) have been extensively studied as promising candidates for small molecule drug delivery. However, the effective encapsulation and intracellular delivery of peptides using small pore-sized MSNs still remain a great technical challenge. In this paper, an effective delivery platform for Bcl-2-converting peptide was fabricated by us to treat multidrug resistant-cancer cells via tuning the surface functionality of macroporous silica nanoparticles. The resulting large-sized pore silica nanoparticles, especially those modified with thiol group, exhibited the high Bcl-2-converting peptide-loading efficiency of over 40%. Moreover, the peptide induced MCF7/DOX cells into apoptotic status by penetrating cytomembrane into mitochondria and being bound with Bcl-2 to expose the BH3 domain with the aid of various surface functionalities-decorated MSNs. In particular, amine-modified surface of MSNs caused the greater influence on the cell apoptosis-inducing effects of peptide in comparison with other functionalities-modified ones. Taken together, our study, for the first time, demonstrates a special approach towards pore size and surface functionality-collectively modulated silica-based nanostructural material for effective delivery of bio-macromolecules (e.g., Bcl-2-converting peptide) to treat the multidrug resistant-cancer cells with elevated Bcl-2 levels. ? 2018
一级学科
Chemistry, Physical
WOS入藏号
WOS:000436528300016
EI收录号
20182105231515
DOI
10.1016/j.jcis.2018.05.033
ESI
CHEMISTRY
收录于
SCIE, EI

返回