英文论文
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文献类型
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Journal article (JA)
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题名
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Persistent luminescence nanoparticles for cancer theranostics application
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作者
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Liu, Nian; Chen, Xiao; Sun, Xia; Sun, Xiaolian; Shi, Junpeng
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作者单位
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[Sun, Xia] Xiamen Univ, Xiamen Cardiovasc Hosp, Xiamen 361015, Peoples R China. [Liu, Nian; Sun, Xiaolian] China Pharmaceut Univ, Dept Pharmaceut Anal, State Key Lab Nat Med, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China. [Liu, Nian] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany. [Chen, Xiao] Ludwig Maximilians Univ Munchen, Med Klin & Poliklin 4, D-80336 Munich, Germany. [Shi, Junpeng] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Peoples R China. [Shi, Junpeng] Chinese Acad Sci, Xiamen Inst Rare Earth Mat, Dept Translat Med, Xiamen 361021, Peoples R China.
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通讯作者地址
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Xiamen Univ, Xiamen Cardiovasc Hosp, Xiamen 361015, Peoples R China.; China Pharmaceut Univ, Dept Pharmaceut Anal, State Key Lab Nat Med, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China.; Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Peoples R China.
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Email
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sunxia8446@qq.com; xiaolian_sun@cpu.edu.cn; shijunpeng10@mails.ucas.edu.cn
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ResearchID
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ORCID
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期刊名称
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Journal of Nanobiotechnology
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出版社
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BioMed Central Ltd
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ISSN
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出版信息
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2021-12, 19 (1):.
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JCR
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1
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影响因子
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7.433
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ISBN
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基金
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National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61705228, 81971738, 81571743]; National Key Research and Development Program of China [2016YFA0203600]; Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University [SKLNMZZRC05]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Diseases; Drug delivery; Laser excitation; Luminescence; Nanoparticles; Photosensitizers; Theranostics; Tumors; Ultraviolet lasers
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摘要
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Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources (UV light, LED, NIR laser, X-ray, and radiopharmaceuticals). Besides, by incorporating other functional molecules, such as photosensitizers, photothermal agents, or therapeutic drugs, PLNPs are also widely used in persistent luminescence (PersL) imaging-guided tumor therapy. In this review, we first summarize the recent developments in the synthesis and surface functionalization of PLNPs, as well as their toxicity studies. We then discuss the in vivo PersL imaging and multimodal imaging from different excitation sources. Furthermore, we highlight PLNPs-based cancer theranostics applications, such as fluorescence-guided surgery, photothermal therapy, photodynamic therapy, drug/gene delivery and combined therapy. Finally, future prospects and challenges of PLNPs in the research of translational medicine are also discussed.
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一级学科
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Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology
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WOS入藏号
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WOS:000642551700002
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EI收录号
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20211710250414
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DOI
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10.1186/s12951-021-00862-z
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ESI
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收录于
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SCIE, EI
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