英文论文


文献类型
Journal article (JA)
题名
A carrier-free metal-coordinated dual-photosensitizers nanotheranostic with glutathione-depletion for fluorescence/photoacoustic imaging-guided tumor phototherapy
作者
Chen, Luping; Zuo, Wenbao; Xiao, Zhimei; Jin, Quanyi; Liu, Jinxue; Wu, Liang; Liu, Nian; Zhu, Xuan
作者单位
[Chen, Luping; Zuo, Wenbao; Jin, Quanyi; Liu, Jinxue; Liu, Nian; Zhu, Xuan] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China. [Xiao, Zhimei; Wu, Liang] Xiamen Univ, Sch Med, Xiamen 361102, Peoples R China.
通讯作者地址
Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China.
Email
zhuxuan@xmu.edu.cn
ResearchID
ORCID
期刊名称
Journal of Colloid and Interface Science
出版社
Academic Press Inc.
ISSN
0021-9797
出版信息
2021-10-15, 600 ():243-255.
JCR
1
影响因子
ISBN
基金
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81772278]
会议名称
会议地点
会议开始日期
会议结束日期
关键词
Cell death; Efficiency; Fluorescence imaging; Metal ions; Peptides; Photodynamic therapy; Red Shift; Stability; Transition metal compounds; Transition metals; Tumors
摘要
As a promising noninvasive tumor treatment modality, dual phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has drawn extensive research interest in imaging-guided synergistic antitumor treatment. However, developing a high-efficient phototherapeutic agent is still a huge challenge, since single photosensitizer often suffers from the insufficient photothermal conversion efficiency (PCE) or low reactive oxygen species (ROS) productivity. Moreover, the overexpression of reductive glutathione (GSH) in tumor cells also severely compromises PDT efficiency. Here, inspired by the glutathione oxidase activity of high-valent transition metal ions, we designed a copper-coordinated nanotheranostic (PhA@NanoICG) by the coordination-driven co-assembly of photothermal-agent indocyanine green (ICG) and photodynamic-agent pheophorbide A (PhA), in which Cu2+ acted as a bridge to tightly associate ICG with PhA. Such carrier-free metal-coordinated nanotheranostics exhibited ultrahigh dual-photosensitizers co-loading (similar to 96.74 wt%) and excellent structural stability. Notably, NanoICG significantly increase the PCE of ICG via J-aggregation induced UV-vis absorption red-shift. Once PhA@NanoICG accumulated in tumor sites, they could be disassembled triggered by the weakly acidic and highly reducible tumor microenvironment. Moreover, the Cu2+ can deplete intracellular GSH and impair cellular antioxidant defense system, reducing the unnecessary ROS consumption caused by glutathione. Under fluorescence/photoacoustic imaging-guided laser irradiation, local hyperthermia and ROS were generated to induce tumor cells apoptosis. The in vitro and in vivo experiments consistently confirm that PhA@NanoICG could induce remarkable tumor inhibition through self-enhanced PTT and PDT, which may pave a new way for cancer therapy. (C) 2021 Elsevier Inc. All rights reserved.
一级学科
Chemistry, Physical
WOS入藏号
WOS:000669038500012
EI收录号
20212110401651
DOI
10.1016/j.jcis.2021.04.131
ESI
收录于
SCIE, EI

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