C-Papers


LWMC
围绝经期女性骨代谢与“血瘀”相关性研究
Title
Correlation analysis between bone metabolism and blood stasis in perimenopausal women
Author
眭承志;刘志坤;甘卫冬;陈舒强;樊孝俊;林振原;陈祺
Institution
厦门大学附属第一医院;厦门中医院
QKMC
中国骨质疏松杂志
CN
11-3701/R
ISSN
1006-7108
FBNY
2016-11-20
Volume
v.22
Issue
11
YM
63-69
GJZ
中医中药;血瘀;甲襞微循环;血液流变;骨代谢标志物
Keywords
Chinese medicine;Blood stasis;Microcirculation;Blood flow;Bone metabolism markers
LWZY
目的探讨围绝经期女性骨代谢状况与"血瘀"的关联性。方法 132例符合纳入标准的围绝经期女性按年龄每5岁为一组,分为4组,采用电化学发光法检测不同阶段Ⅰ型胶原氨基端前肽(PINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、骨钙素N-端中分子片段(N-MID)等骨代谢指标,同时检测血液流变学指标,并对其进行"血瘀"量化评分、甲襞微循环评分,相关数据采用多元回归等统计学进行分析。结果 PINP与全血中切粘度、血瘀量化评分、甲襞微循环评分存在显著的正相关(P<0.01);β-CTX与血瘀量化评分、甲襞微循环评分存在显著的正相关(P<0.01),与红细胞电泳时间存在显著负相关(P<0.01),与全血低切粘度、红细胞刚性指数存在正相关(P<0.05);N-MID与全血中切粘度、血瘀量化评分、甲襞微循环评分存在显著正相关(P<0.01)与全血低切粘度存在正相关(P<0.05)。结论围绝经女性骨代谢状况与"血瘀"关系密切,血瘀是导致围绝经女性骨代谢状况发生变化而发生骨质疏松的重要因素之一。
Abstract
Objective To discuss the correlation between bone metabolism and blood stasis in perimenopausal women. Me thods132 cases of perimenopausal women meeting the inclusion criteria were divided into 4 groups by every 5-year age. Type I collagen amino-terminal propeptide( PINP),carboxy-terminal peptide β special sequence( β-CTX),and molecular osteocalcin N- terminal fragment( N-MID) were detected with electrochemical luminescence at different stages. Blood rheology,blood stasis quantitative score,and microcirculation score were simultaneously detected. Data were analyzed using multiple regression method. Re sults PINP was positively correlated with shear viscosity of whole blood,blood stasis quantitative score,and microcirculation score( P <0. 01). β-CTX was positively correlated with blood stasis quantitative score,microcirculation score,lowshear whole blood viscosity,and erythrocyte rigidity index( P < 0. 01),but was negatively correlated with erythrocyte electrophoresis time( P <0. 01). N-MID was positively correlated with whole blood viscosity,blood stasis quantitative score,microcirculation score( P <0. 01),and lowshear whole blood viscosity( P < 0. 05). Conclusion Bone metabolism and blood stasis are closely related in perimenopausal women. Blood stasis is one of the important factors leading to osteoporosis and change of bone metabolism in perimenopausal women.
Ref
[1]眭承志,周军,刘志坤.绝经后骨质疏松症血瘀病机的客观初步论证.中医研究,2005,18(1):30-33.SUI Chengzhi,ZHOU Jun,LIU Zhikun.Postmenopausal osteoporosis objective preliminary demonstration of the Pathogenesis of Blood.Traditional Chinese Medicinal Research,2005,18(1):30-33. [2]眭承志,刘志坤,陈少玫,等.绝经后骨质疏松症血瘀病机的微观分子生物学论证.中医研究,2005,18(4):19-23.SUI Cheng-zhi,LIU Zhi-kun,CHEN Shao-mei,et al.Microscopic molecular biology demonstration of osteoporosis in postmenopausal Pathogenesis of Blood.Traditional Chinese Medicinal Research,2005,18(4):19-23. [3]眭承志,王彦伟,刘志坤,等.血瘀证在绝经后骨质疏松症中的量化研究.中医药通报,2005,4(2):32-34.SUI Cheng-zhi,WANG Yan-wei,LIU Zhi-kun,et al.Quantitative study of the blood stasis postmenopausal osteoporosis in.Traditional Chinese Medicine Journal,2005,4(2):32-34. [4]甘卫冬,眭承志.从血管内皮功能探讨雌激素与血疲关联性的研究.中国骨质疏松杂志,2014,20(4):711-713.GAN Wei-dong,SUI Cheng-zhi.Discussion of estrogen and blood from the tired association endothelial function.Chinese Journal of loose bone,2014,20(4):711-713. [5]乐杰.妇产科学.6版.北京:人民卫生出版社,2003:349-350.Le Jie.Obstetrics and Gynecology.6 edition.Beijing:People's Medical Publishing House,2003:349-350. [6]田牛.实用临床微循环学.北京:军事科学出版社,1989:28-31.Tian Niu.Applied Clinical Microcirculation.Beijing:Military Science Press,1989:28-31. [7]王宁华.疼痛定量评定的进展.中国临床康复,2002,6(18):2738-2739.Wang Ling-hua.Quantitative assessment of progress in pain.Chinese Journal of Clinical Rehabilitation,2002,6(18):2738-2739. [8]周丕琪,沈霖,杜靖远,等.绝经后骨质疏松症与血清IL-6,TNF-α浓度关系的临床研究.中国骨质疏松杂志,2001,7(1):1-3.Zhou Pei-qi,Shen Lin,Du Jing-yuan,et al.Postmenopausal osteoporosis and serum IL-6,TNF-αconcentrations of clinical research relations.Chinese Journal of Bone osteoporosis,2001,7(1):1-3. [9]吴大梅,冯麟,杨爱国,等.从五脏病机浅谈血瘀证的形成.贵阳中医院学报,2006,28(3):6-7.Wu Da-mei,Feng Lin,Yang Ai-guo,et al.Heart disease from five machines of forming blood stasis syndrome.Journal of Traditional Chinese Medicine Hospital of Guiyang,2006,28(3):6-7. [10]范燕妮,眭承志.老年性骨质疏松血瘀病机的微观分子生物学论证.中医骨伤,2010,10(6):7-8.Fan Yan-ni,Sui Cheng-zhi,et al.Microscopic molecular biology demonstrate senile osteoporosis Pathogenesis of Blood.Orthopedics,2010,10(6):7-8. [11]董银卯,刘文婷,何聪芬.面部毛细血管扩张生物学机理研究进展.中国中西医结合杂志,2010,20(2):16-18.Dong Yin-mao,Liu Wen-ting,He Chong-fen.Advances in Biological Mechanism of facial telangiectasia.Chinese Medicine,2010,20(2):16-18. [12]亚白柳,李林.高脂血症与微循环功能障碍研究进展.医学综述,2011,17(20):3041-3043.Ya Bai-liu,Li Lin.Hyperlipidemia and microcirculation dysfunction Progress.Medical Review,2011,17(20):3041-3043. [13]眭承志,周军.从瘀论治绝经后骨质疏松症的理论探析.中医药学刊,2005,23(1):92-93,173.SUI Cheng-zhi,ZHOU Jun.Theoretical Analysis from osteoporosis after menopause Blood Stasis.TCM,2005,23(1):92-93,173. [14]林远方,曹亚飞,陈小砖,等.绝经后妇女活性氧与破骨细胞活性的关系.中医正骨,2003:3(15):137.LIN Yuan-fang,CAO Ya-fei,CHEN Xiao-zhuan,et al.Reactive oxygen species and the relationship between women osteoclast activity in postmenopausal women.Orthopaedics and Traumatology,2003:3(15):137.
Fund_Code
福建省医学创新课题(2012-CXB-26);; 福建省中医药课题(WST201205)
FileName
ZGZS201611012

Back to List