厦门大学学者库

中文论文

论文题名
血清抗苗勒管激素检测40岁以上不孕患者IVF中临床意义的探讨
英文题名
Clinical significance of serum anti-Müllerian hormone detection of IVF in infertile patients over 40 years of age
作者
张玲;邸玥莹;梅俊;蓝惠华;高鹏;王厚照
作者单位
厦门大学附属成功医院/解放军第174医院中心实验室
期刊名称
中国优生与遗传杂志
CN号
11-3743/R
ISSN
1006-9534
出版日期
2016-11-25
卷
v.24
期
11
页码
92+109-110
中文关键词
高龄不孕;抗苗勒氏管激素;体外受精;妊娠
英文关键词
Aged infertility;Anti-Müllerian hormone;Fertilization in vitro;Pregnancy rate
中文摘要
目的探讨抗苗勒氏管激素(AMH)水平对年龄超过40岁的患者行体外受精-胚胎移植、卵胞浆内单精子注射(IVF/ICSI-ET)周期妊娠结局的预测意义。方法我们回顾性分析了我院生殖中心就诊的188名年龄在40岁到44岁接受IVF/ICSI新鲜胚胎移植周期不孕患者的医疗记录。患者随机分为A组,与AMH水平<1ng/ml(n=97),B组与AMH水平≥1ng/ml(n=91)。我们比较了两组的临床妊娠率(CPR),并进行了逻辑回归分析。结果 A组的临床妊娠率明显低于B组(24.2%比7.2%,P﹤0.001),多因素Logistic回归分析,AMH水平是对临床妊娠率显著影响的唯一因素(优势比,1.510;95%置信区间,1.172-1.947)。结论我们的研究表明,AMH水平预测年龄超过40岁不孕患者临床妊娠结局。
英文摘要
Objective:To determine the predictive value of anti-Müllerian hormone(AMH)levels for pregnancy outcomes in patients over 40 years of age who underwent in vitro fertilization or intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET)cycles. Methods:We retrospectively analyzed the medical records of 188 women aged 40 to 44 years who underwent IVF/ICSI-fresh ET cycles due to unexplained infertility in the reproductive center of our hospital. Patients were divided into group A,with AMH levels <1.0 ng/ml(n=97),and group B,with AMH levels ≥1.0 ng/ml(n=91). We compared the clinical pregnancy rate(CPR)in the two groups and performed logistic regression analysis to identify factors that had a significant effect on the CPR. Results:The CPR was significantly lower in group A than group B(7.2% vs. 24.2%, P﹤0.001). In multivariate logistic regression analysis,AMH levels were the only factor that had a significant impact on the CPR(odds ratio,1.510;95% confidence interval,1.172-1.947). Conclusion:Our study showed that AMH levels were predictive of clinical pregnancy in infertility patients over 40 years of age.
参考文献
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基金
厦门市科技惠民项目3502Z20144036

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