C-Papers


LWMC
肿瘤微环境响应型磁性纳米粒子组装用于肝癌的可视化治疗
Title
Author
凌代舜;孔学谦;孙晓莲
Institution
浙江大学药学院;浙江大学化学系;厦门大学公共卫生学院
QKMC
生物技术通报
CN
11-2396/Q
ISSN
1002-5464
FBNY
2016-11-26
Volume
v.32;No.292
Issue
11
YM
289-291
GJZ
Keywords
LWZY
<正>肝癌是我国最常见的恶性肿瘤之一,死亡率居第二位。早期诊断与个体化治疗是提高肝癌治愈率的关键。可视化治疗有望实现实时监测的个体化治疗:在治疗前期,成像技术提供较准确的信息,如肿瘤的大小、位置、和周围组织之间的关系,利于拟定治疗方案;治疗过程中,直观把控治疗进程,可以及时调整或更换治疗方案;治疗结束后,进一步监测疾病后续发展[1,2]。磁性纳米粒具有优异的磁共振成像(MRI)性能以及磁致发热性能,在肿瘤诊断与治疗领域受到
Abstract
Ref
[1]Lammers T,Aime S,Hennink WE,et al.Theranostic nanomedicine[J].Accounts Chem Res,2011,44(10):1029-1038. [2]Janib SM,Moses AS,Mac Kay JA.Imaging and drug delivery usingtheranostic nanoparticles[J].Adv Drug Delivery Rev,2010,62(11):1052-1063. [3]Kim BH,Lee N,Kim H,et al.Large-scale synthesis of uniform andextremely small-sized iron oxide nanoparticles for high-resolution T1magnetic resonance imaging contrast agents[J].J Am Chem Soc,2011,133(32):12624-12631. [4]Lee JH,Huh YM,Jun Y,et al.Artificially engineered magneticnanoparticles for ultra-sensitive molecular imaging[J].Nat Med,2007,13(1):95-99. [5]Lee JH,Jang J,Choi J,et al.Exchange-coupled magneticnanoparticles for efficient heat induction[J].Nat Nanotechnol,2011,6(7):418-422. [6]Xing R,Zhang F,Xie J,et al.Polyaspartic acid coated manganeseoxide nanoparticles for efficient liver MRI[J].Nanoscale,2011,3(12):4943-4945. [7]Hong G,Yuan R,Liang B,et al.Folate-functionalized polymericmicelle as hepatic carcinoma-targeted,mri-ultrasensitive deliverysystem of antitumor drugs[J].Biomed Microdevices,2008,10(5):693-700. [8]Maeng JH,Lee DH,Jung KH,et al.Multifunctional doxorubicinloaded superparamagnetic iron oxide nanoparticles for chemotherapyand magnetic resonance imaging in liver cancer[J].Biomaterials,2010,31(18):4995-5006.
Fund_Code
FileName
SWJT201611038

Back to List