英文论文
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文献类型
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Journal article (JA)
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题名
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Synthesis and characterization of chitosan-pectin fabricated nanoemulsion for ethylhexyl triazone topical delivery
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作者
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Chu, Chee Chin; Chew, Sook Chin; Nyam, Kar Lin
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作者单位
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[Chu, Chee Chin] Taylors Univ, Fac Hlth & Med Sci, Sch Pharm, Subang Jaya 47500, Malaysia. [Chu, Chee Chin] Taylors Univ, Food Secur & Nutr Impact Lab, Subang Jaya 47500, Selangor, Malaysia. [Chew, Sook Chin] Xiamen Univ Malaysia, China ASEAN Coll Marine Sci, Sepang 43900, Selangor, Malaysia. [Nyam, Kar Lin] UCSI Univ, Fac Appl Sci, Dept Food Sci & Nutr, Kuala Lumpur 56000, Malaysia.
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通讯作者地址
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Taylors Univ, Fac Hlth & Med Sci, Sch Pharm, Subang Jaya 47500, Malaysia.; Taylors Univ, Food Secur & Nutr Impact Lab, Subang Jaya 47500, Selangor, Malaysia.
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Email
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cheechin.chu@taylors.edu.my
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ResearchID
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ORCID
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期刊名称
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Journal of Molecular Structure
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出版社
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ELSEVIER
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ISSN
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0022-2860
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出版信息
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2025-02-05, 1321 ():.
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JCR
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影响因子
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ISBN
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基金
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Chemical Solutions Sdn Bhd.
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Chitosan; Shear deformation; Shear thinning; Sun hoods
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摘要
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This study aimed to investigate the stability of nanoemulsions for the UVB filter, ethylhexyl triazone (EHT) encapsulation followed by fabrication with chitosan and pectin. Four formulations were developed to assess the influence of hydrophile-lipophile balance (HLB) values on nanoemulsion stability for EHT encapsulation, targeting high Sun Protection Factor (SPF) values. The selected nanoemulsion was then subjected to fabrication with chitosan and pectin, followed by physical characterization and rheological behaviour study. Results indicated that all nanoemulsions exhibited particle sizes ranging from 137.7 nm to 206.0 nm and high entrapment efficiency from 88.76 % to 91.98 %. Sample N3, containing 1 % Tween 20 and 2 % polyethylene glycol (PEG) 400 with HLB of 12, demonstrated the highest stability, yielding a significantly elevated SPF value (10.33). Moreover, polymer-coated nanoemulsions with a low concentration of chitosan (0.1 %) showed enhanced stability when combined with different percentages of pectin. Polymer-coated nanoemulsions indicated shear- thinning behaviour at lower shear rates to Newtonian flow at higher shear rate. Furthermore, both polymer- coated and uncoated nanoemulsions exhibited decreased viscosity with increasing temperature. Also, polymer- coated nanoemulsions was found to enhance the sustainable release of EHT. These findings demonstrated the potential of polymer-coated nanoemulsions for skin application, offering enhanced stability and improved flow behaviour. The design of polymer-coated nanoemulsions could potentially minimize the risks of accumulation and toxicity of UV filters by providing a sustainable release behaviour.
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一级学科
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Chemistry, Physical
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WOS入藏号
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WOS:001332993900001
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EI收录号
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20244017149082
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DOI
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10.1016/j.molstruc.2024.140199
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ESI
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收录于
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SCIE, EI
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