英文论文


文献类型
Journal article (JA)
题名
Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy
作者
Huang, Xueying; Deng, Long; Zuo, Heng; Yang, Chun; Song, Yunhu; Lesperance, Mary; Tang, Dalin
作者单位
[Huang, Xueying] Xiamen Univ, Sch Math Sci, Xiamen 361005, Fujian, Peoples R China. [Huang, Xueying; Yang, Chun; Tang, Dalin] Worcester Polytech Inst, Math Sci Dept, Worcester, MA 01609 USA. [Deng, Long; Song, Yunhu] Chinese Acad Med Sci, Fuwai Hosp, Dept Cardiac Surg, Beijing, Peoples R China. [Zuo, Heng] Sichuan Normal Univ, Sch Math Sci, Chengdu, Sichuan, Peoples R China. [Yang, Chun] China United Network Commun Co Ltd, Network Technol Res Inst, Beijing, Peoples R China. [Lesperance, Mary] Univ Victoria, Dept Math & Stat, Victoria, BC V8P 5C2, Canada. [Tang, Dalin] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing, Peoples R China.
通讯作者地址
Xiamen Univ, Sch Math Sci, Xiamen 361005, Fujian, Peoples R China.; Worcester Polytech Inst, Math Sci Dept, Worcester, MA 01609 USA.
Email
xhuang@xmu.edu.cn
ResearchID
ORCID
期刊名称
BioMedical Engineering Online
出版社
BioMed Central Ltd
ISSN
出版信息
2021-12, 20 (1):.
JCR
4
影响因子
2.297
ISBN
基金
Natural Science Foundation of Fujian Province of ChinaNatural Science Foundation of Fujian Province [2017J01009]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [20720180004]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11672001, 82000472, 11671335, 11972117]; NIH/NHLBIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01 HL089269]
会议名称
会议地点
会议开始日期
会议结束日期
关键词
Boundary conditions; Computation theory; Computational methods; Computerized tomography; Heart; Hemodynamics; Shear stress
摘要
Background Patient-specific active fluid-structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. Methods The simulation results of 12 passive FSI models based on 6 patients' pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results In comparing the passive and active models, it was found that there was no significant difference in pressure difference and shear stress on mitral valve leaflet (MVL) at the pre-SAM time point, but a significant difference was found in wall stress on the inner boundary of left ventricle (endocardium). It was also found that pressure difference on the coapted MVL and the shear stress on MVL were significantly decreased after successful surgery in both active and passive models. Conclusion Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. These findings suggest that, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis of the initiation of SAM.
一级学科
Engineering, Biomedical
WOS入藏号
WOS:000607401000001
EI收录号
20210309783188
DOI
10.1186/s12938-020-00838-4
ESI
收录于
SCIE, EI

返回