英文论文


文献类型
Journal article (JA)
题名
Engineered bio-adhesive polyhedral oligomeric silsesquioxane hybrid nanoformulation of amphotericin B for prolonged therapy of fungal keratitis
作者
Han, Yi; Xu, Chenfang; Shi, Huihui; Yu, Fei; Zhong, Yanlin; Liu, Zuguo; Loh, Xian Jun; Wu, Yun-Long; Li, Zibiao; Li, Cheng
作者单位
[Han, Yi; Yu, Fei; Zhong, Yanlin; Liu, Zuguo; Li, Cheng] Xiamen Univ, Eye Inst, Fujian Prov Key Lab Ophthalmol & Visual Sci & Ocu, Xiamen 361102, Peoples R China. [Han, Yi; Yu, Fei; Zhong, Yanlin; Liu, Zuguo; Li, Cheng] Xiamen Univ, Affiliated Xiamen Eye Ctr, Sch Med, Xiamen 361102, Peoples R China. [Xu, Chenfang; Wu, Yun-Long] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China. [Xu, Chenfang; Wu, Yun-Long] Xiamen Univ, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China. [Shi, Huihui] Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China. [Shi, Huihui] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Key Lab Marine Mat & Protect Technol, Key Lab Marine Mat & Related Technol, Ningbo 315201, Peoples R China. [Loh, Xian Jun; Li, Zibiao] ASTAR, Inst Mat Res & Engn, Singapore 138634, Singapore.
通讯作者地址
; ; Xiamen Univ, Eye Inst, 4th Floor,Chengyi Bldg,4221-122,South Xiangan Rd, Xiamen 361102, Fujian, Peoples R China.
Email
wuyl@xmu.edu.cn; lizb@imre.a-star.edu.sg; cheng-li@xmu.edu.cn
ResearchID
ORCID
期刊名称
Chemical Engineering Journal
出版社
Elsevier B.V.
ISSN
1385-8947
出版信息
2021-10-01, 421 ():.
JCR
1
影响因子
ISBN
基金
National Key R&D Program of China [2020YFA0908103, 2018YFA0107301]; National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [82070931, 81770891, 81672955, 81971724, 81773661]; Agency for Science, Technology and Research (A*STAR) under its AME IAF-PP Specialty Chemicals Program [A1786a0034]; Huaxia Translational Medicine Fund for Young Scholars [2017A001]
会议名称
会议地点
会议开始日期
会议结束日期
关键词
Adhesives; Biocompatibility; Drug delivery; Micelles; Oligomers; organic-inorganic materials; Polyethylene glycols; Polyethylene oxides
摘要
Even though fungal keratitis is a severe corneal disease that can lead to permanent vision loss, its therapeutic management is still problematic. This limitation is in part attributable to the fact that tear film renewal curtails exposure time of drug containing eye drops to the ocular surface. Accordingly, anti-microbial therapy needs to be performed repeatedly. Efforts to resolve this hindrance include developing formulations that prolong drug retention on the ocular surface which can in turn improve therapeutic efficacy as well as reduce administration frequency. To extend drug residence time on the ocular surface, we designed a novel organic-inorganic hybrid consisting of a PEG-PPG copolymer modified with polyhedral oligomeric silsesquioxane (POSS) groups. Its tailored POSS-micelles possess both good biocompatibility and bio-adhesiveness, which improve ocular delivery of poorly soluble drugs. We describe here use of mouse fungal keratitis model to determine the effects of this formulation encapsulating amphotericin B (AMB) on this condition. The results show that POSS-micelles significantly prolonged AMB retention time on the ocular surface, leading to improved resolution of this disease. Moreover, this treatment strategy had no toxic effects during ocular administration either in vitro or in vivo. Therefore, this POSS formulation bearing AMB has the potential to prolong drug retention time and improve its therapeutic efficacy in managing fungal keratitis.
一级学科
Engineering, Environmental; Engineering, Chemical
WOS入藏号
WOS:000664132200002
EI收录号
20211710255362
DOI
10.1016/j.cej.2021.129734
ESI
收录于
SCIE, EI

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