Algicidal bacteria-derived membrane vesicles as shuttles mediating cross-kingdom interactions between bacteria and algae

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

A Two-Step Enzymatic Cascade for Synthesis of Diverse Ephedra-Type Alkaloids

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia

Deaggregation of mutant <i>Plasmodium yoelii</i> de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance

Unveiling the State Transition Mechanisms of Ras Proteins through Enhanced Sampling and QM/MM Simulations

Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis

Discovery of urea-based pleuromutilin derivatives as potent gram-positive antibacterial agents

Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strategy

Rational design of a polysaccharide-based viral mimicry nanocomplex for potent gene silencing in inflammatory tissues

Human Polo-like Kinase Inhibitors as Antiplasmodials

Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice

Deep-ultraviolet photonics for the disinfection of SARS-CoV-2 and its variants (Delta and Omicron) in the cryogenic environment

Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms

Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens

Paspalines C-D and Paxillines B-D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69

Atomic resolution Cryo-EM structure of human proteasome activator PA28?

Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system

HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC

H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform

PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron

NF-kappa B Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice

Role of SPAK-NKCC1 signaling cascade in the choroid plexus blood-CSF barrier damage after stroke

Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations

Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process

An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Pharmacological targeting PIKfyve and tubulin as an effective treatment strategy for double-hit lymphoma

A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC

Pentacyclic Cytochalasins and Their Derivatives from the Endophytic Fungus Phomopsis sp. xz-18

Glycogen accumulation and phase separation drives liver tumor initiation

Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor

SPAK/OSR1 Signaling as a Novel Target for Post-Stroke Oxidative Stress Brain Injury.

Discovery of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl )-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d] pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-met hyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma

Blocking PPAR gamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a

Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition

A 3D-Printed Self-Adhesive Bandage with Drug Release for Peripheral Nerve Repair

A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk(C481S) mutation in B-cell malignancies

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair

Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: stereocontrolled access to bridged [4.2.1] lactones

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases

Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis

Close-loop dynamic nanohybrids on collagen-ark with: In situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

Discovering a novel microtubule inhibitor overcoming tumor multidrug resistance

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities

ERK5 is activated by oncogenic BRAF and promotes melanoma growth

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases

New 12,8-Eudesmanolides from Eutypella sp 1-15

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Nonomuraea ceibae sp nov., an actinobacterium isolated from Ceiba speciosa rhizosphere

Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins

Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition

Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-delta/gamma Inhibitors

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Direct Targeting of beta-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/beta-Catenin Signaling

Two New Ring A-Cleaved Lanostane-Type Triterpenoids and Four Known Steroids Isolated from Endophytic Fungus Glomerella sp. F00244

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

Cytochalasans and Sesquiterpenes from Eutypella scoparia 1-15

Aspertetranones A-D, Putative Meroterpenoids from the Marine Algal-Associated Fungus Aspergillus sp ZL0-1b14

Kribbella mirabilis sp nov., isolated from rhizosphere soil of a herbaceous plant, Mirabilis jalapa L.

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma

Kibdelosporangium lantanae sp nov., isolated from the rhizosphere soil of an ornamental plant, Lantana camara L.

Four New Cycloheximide Derivatives from Streptomyces sp h-119

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006-2011)

Pyrazolopyridines as inhibitors of the kinase LRRK2: a patent evaluation (WO2011141756)

Hippo pathway in intestinal homeostasis and tumorigenesis