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WOK 论文 127 篇;中文核心 15 篇;专利发明 3 个;
TCR-like bispecific antibodies toward eliminating infected hepatocytes in HBV mouse models
Both middle and large envelope proteins can mediate neutralization of hepatitis B virus infectivity by anti-preS2 antibodies: escape by naturally occurring preS2 deletions
Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Major HBV splice variant encoding a novel protein important for infection
Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects
Therapeutic vaccine-induced plasma cell differentiation is defective in the presence of persistently high HBsAg levels
Swine pseudorabies virus attenuated vaccine reprograms the kidney cancer tumor microenvironment and synergizes with PD-1 blockade
Light-Induced Mechanically Robust Hydrogel with Superelasticity and Fatigue Resistance for Bioprinting of Cell-Laden Architectures
A Dual-domain Engineered Antibody for Efficient HBV Suppression and Immune Responses Restoration
Evolution of the SARS-CoV-2 Omicron Variants: Genetic Impact on Viral Fitness
Micronanoparticled risedronate exhibits potent vaccine adjuvant effects
A glycoengineered therapeutic anti-HBV antibody that allows increased HBsAg immunoclearance improves HBV suppression <i>in vivo</i>
The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors
Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant
MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion
Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies
Effectiveness of first and second boost COVID-19 vaccination in healthy adults during BA.5.2/BF.7 surge in China
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters
Combination therapy of therapeutic antibody and vaccine or entecavir in HBV carrier mice
Hepatitis B Core Antibody Level: A Surrogate Marker for Host Antiviral Immunity in Chronic Hepatitis B Virus Infections
A Heterologous Challenge Rescues the Attenuated Immunogenicity of SARS-CoV-2 Omicron BA.1 Variant in Syrian Hamster Model
Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus
A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model
Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine
The duration and breadth of antibody responses to 3-dose of inactivated COVID-19 vaccinations in healthy blood donors: An observational study
New discovery of high-affinity SARS-CoV-2 spike S2 protein binding peptide selected by PhIP-Seq
Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters
Potential of conserved antigenic sites in development of universal SARS-like coronavirus vaccines
Receptor-binding domain-anchored peptides block binding of severe acute respiratory syndrome coronavirus 2 spike proteins with cell surface angiotensin-converting enzyme 2
Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells
Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells
Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron
Cross-species tropism and antigenic landscapes of SARS-CoV-2 variants
Risk of hepatocellular carcinoma in antiviral treatment-naive chronic hepatitis B patients treated with entecavir or tenofovir disoproxil fumarate: a network meta-analysis
5 ' preS1 Mutations To Prevent Large Envelope Protein Expression from Hepatitis B Virus Genotype A or Genotype D Markedly Increase Polymerase-Envelope Fusion Protein
A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19
A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway (vol 8, pg 549, 2018)
A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2
Baseline Quantitative Hepatitis B Core Antibody Titer Is a Predictor for Hepatitis B Virus Infection Recurrence After Orthotopic Liver Transplantation
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters
Lost Small Envelope Protein Expression from Naturally Occurring PreS1 Deletion Mutants of Hepatitis B Virus Is Often Accompanied by Increased HBx and Core Protein Expression as Well as Genome Replication
Role of Small Envelope Protein in Sustaining the Intracellular and Extracellular Levels of Hepatitis B Virus Large and Middle Envelope Proteins
SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA
Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster
Replication, pathogenicity, and transmission of SARS-CoV-2 in minks
Naturally occurring 5' preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C
Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors
Preparation and functional evaluation of monoclonal antibodies targeting Hepatitis B Virus Polymerase
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection
A SCID mouse-human lung xenograft model of SARS-CoV-2 infection
Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019
Expression Level of Small Envelope Protein in Addition to Sequence Divergence inside Its Major Hydrophilic Region Contributes to More Efficient Surface Antigen Secretion by Hepatitis B Virus Subgenotype D2 than Subgenotype A2
Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset
Structure guided maturation of a novel humanized anti-HBV antibody and its preclinical development
Quantatitative assays for covalently closed circular DNA of hepatitis B virus
A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice
Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens
SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates
Robust neutralization assay based on SARS-CoV-2 S-protein-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressing BHK21 cells
Nanobody-based sandwich reporter system for living cell sensing influenza A virus infection
HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation
Agonist c-Met monoclonal antibody augments the proliferation of hiPSC-derived hepatocyte-like cells and improves cell transplantation therapy for liver failure in mice
Simultaneous in situ visualization and quantitation of dual antigens adsorbed on adjuvants using high content analysis
Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection
Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus
Structure and function analysis of the C-elegans aminophospholipid translocase TAT-1
Level of Hepatitis B (HB) Core Antibody Associates With Seroclearance of HBV DNA and HB Surface Antigen in HB e Antigen-Seronegative Patients
Agonist c-Met Monoclonal Antibody Augments the Proliferation of hiPSC-derived Hepatocyte-Like Cells and Improves Cell Transplantation Therapy for Liver Failure in Mice
Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection
Quantification of HBV core antibodies may help predict HBV reactivation in patients with lymphoma and resolved HBV infection
ER stress regulating protein phosphatase 2A-B56 gamma, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes
A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection
A novel noninvasive index for the prediction of moderate to severe fibrosis in chronic hepatitis B patients
Lower baseline quantitative HBcAb may help predict response to sequential combination therapy with IFN, rhIL-2 and HBV therapeutic vaccine in entecavir-suppressed CHB patients
Role of quantitative hepatitis B core antibody levels in predicting significant liver inflammation in chronic hepatitis B patients with normal or near-normal alanine aminotransferase levels
A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys
A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway
Bioinspired Artificial Nanodecoys for Hepatitis B Virus
The unique antibody suppresses HBV viremia and reduces hepatocarcinogenesis in HBV-transgenic mice
Long-term outcome of inactive and active, low viraemic HBeAg-negative-hepatitis B virus infection: Benign course towards HBsAg clearance
A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses
Detection of HBV Covalently Closed Circular DNA
Low viremic HBeAg negative HBsAg carriers: Clinical outcome and non invasive diagnostic accuracy for chronic hepatitis B or inactive infection by combinations of HBV markers
Baseline hepatitis B core antibody predicts treatment response in chronic hepatitis B patients receiving long-term entecavir
A novel toolbox for the in vitro assay of hepatitis D virus infection
Low viremic HBeAg negative HBsAg carriers: clinical outcome and non invasive diagnostic accuracy for chronic hepatitis B or inactive infection by combinations of HBV markers
The gRNA-miRNA-gRNA Ternary Cassette Combining CRISPR/Cas9 with RNAi Approach Strongly Inhibits Hepatitis B Virus Replication
Antibody-mediated immunotherapy against chronic hepatitis B virus infection
Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells
Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound
Baseline Quantitative Hepatitis B Core Antibody Level strongly Predicts 240-week Treatment Response in HBeAg-positive Chronic Hepatitis B Patients Receiving Entecavir
Functional characterization of hepatitis B virus core promoter mutants revealed transcriptional interference among co-terminal viral mRNAs
An HBV-tolerant immunocompetent model that effectively simulates chronic hepatitis B virus infection in mice
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Sleeping Beauty transposon-based system for rapid generation of HBV-replicating stable cell lines
A fast and low-cost genotyping method for hepatitis B virus based on pattern recognition in point-of-care settings
Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen
Detection and analysis of tupaia hepatocytes via mAbs against tupaia serum albumin
Development of an HSV-1 neutralization test with a glycoprotein D specific antibody for measurement of neutralizing antibody titer in human sera
Evaluation of a novel chemiluminescent microplate enzyme immunoassay for hepatitis B surface antigen detection
Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues
Total Hepatitis B Core Antigen Antibody, a Quantitative Non-Invasive Marker of Hepatitis B Virus Induced Liver Disease
Rapid fluorescent lateral-flow immunoassay for hepatitis B virus genotyping
Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis
Toward the development of monoclonal antibody-based assays to probe virion-like epitopes in hepatitis B vaccine antigen
HBV life cycle is restricted in mouse hepatocytes expressing human NTCP
Baseline Quantitative Hepatitis B Core antibody is the Strongest Predictor for 2-year HBeAg seroconversion in HBeAg Positive CHB Patients Treated with Telbivudine Alone or Combined with Adefovir
Serum miR-483-5p as a potential biomarker to detect hepatocellular carcinoma
Performance evaluation of three different immunoassays for detection of antibodies to hepatitis B core
Hepatitis B Virus Surface Antigen (HBsAg)-Positive and HBsAg-Negative Hepatitis B Virus Infection among Mother-Teenager Pairs 13 Years after Neonatal Hepatitis B Virus Vaccination
TYPE II GROUND GLASS HEPATOCYTES CO-EXPRESS HBSAG AND HBX PROTEINS AND REPRESENT PRENEOPLASTIC LESIONS
Molecular and Phylogenetic Analyses Suggest an Additional Hepatitis B Virus Genotype
新型冠状病毒及泛β冠状病毒广谱中和单抗的研究进展
微生物学报,0001-6209,2023-06-14.基于水疱性口炎病毒(VSV)的溶瘤病毒研究进展
中国生物工程杂志,1671-8135,2020-06-15.HBV cccDNA检测方法的研究进展
科学通报,0023-074X,2020-05-22.2019新型冠状病毒感染血清学检测的临床和公共卫生意义探讨
病毒学报,1000-8721,2020-03-27.细胞穿膜肽研究应用的新进展
生物工程学报,1000-3061,2019-07-25.乙型肝炎病毒体外感染和复制的细胞模型
微生物学报,0001-6209,2019-07-11.乙型肝炎病毒体外感染和复制的细胞模型
微生物学报,0001-6209,2019-07-11.慢性乙型肝炎潜在治疗靶点和新药研发进展
微生物学报,0001-6209,2019-03-15.一种现场快速型HBV基因分型方法及装置
中国生物医学工程学报,0258-8021,2017.乙型肝炎病毒核心抗体定量水平的临床意义
中华肝脏病杂志,1007-3418,2017.抗PD-L1单抗的研制及其对乙型肝炎病毒的抑制效果初步研究
中国免疫学杂志,1000-484X,2016-07-20.一株乙型肝炎病毒鼠单抗的人源化及生物学活性鉴定
厦门大学学报(自然科学版),0438-0479,2016-05-16.利用Gibson Assembly技术构建乙型肝炎病毒1.1倍体复制子
厦门大学学报(自然科学版),0438-0479,2015-05-28.大连地区无偿献血者隐匿性乙型肝炎病毒感染pre-S/S区基因分析
中国输血杂志,1004-549X,2015-01-25.1种新型国产超敏HBsAg试剂在血液筛查中的应用研究
中国输血杂志,1004-549X,2013-08-25.Anti-HBc定量检测方法及其在监控慢性乙肝患者病情发展和预测治疗疗效中的用途
CN103217533B,2016-01-06.