英文论文
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文献类型
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Article
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题名
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Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles
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作者
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Li, Huizhen; Xu, Wan; Li, Fang; Zeng, Ru; Zhang, Xiuming; Wang, Xianwu; Zhao, Shaojun; Weng, Jian; Li, Zhu; Sun, Liping
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作者单位
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[Li, Huizhen; Xu, Wan; Zhang, Xiuming; Weng, Jian; Sun, Liping] Xiamen Univ, Higher Educ Key Lab Biomed Engn Fujian Prov, Res Ctr Biomed Engn Xiamen, Dept Biomat,Coll Mat, Xiamen, Peoples R China. [Li, Huizhen] Zhengzhou Univ, Dept Radiotherapy, Affiliated Hosp 1, Zhengdong Branch, Zhengzhou, Peoples R China. [Li, Fang] Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Genet Resources, Xiamen, Peoples R China. [Zeng, Ru] Xiamen Univ, Dept Med Oncol, Affiliated Hosp 1, Xiamen, Peoples R China. [Wang, Xianwu; Zhao, Shaojun; Li, Zhu] Xiamen Nuokangde Biol Technol Co Ltd, Xiamen, Peoples R China.
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通讯作者地址
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Xiamen Univ, Higher Educ Key Lab Biomed Engn Fujian Prov, Res Ctr Biomed Engn Xiamen, Dept Biomat,Coll Mat, Xiamen, Peoples R China.; Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Genet Resources, Xiamen, Peoples R China.; Xiamen Nuokangde Biol Technol Co Ltd, Xiamen, Peoples R China.
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Email
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lifang@tio.org.cn; lizhu@nkdbio.com; sunliping@xmu.edu.cn
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ResearchID
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ORCID
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期刊名称
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DRUG DELIVERY
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出版社
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TAYLOR & FRANCIS LTD
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ISSN
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1071-7544
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出版信息
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2022-12-31, 29 (1):192-202.
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JCR
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影响因子
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ISBN
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基金
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National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872415]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Extracellular vesicles; doxorubicin; lonidamine; cancer therapy; lung cancer
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摘要
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Chemotherapy is commonly used for the treatment of lung cancer, but strong side effects and low treatment efficacy limit its clinical application. Here, extracellular vesicles (EVs) as natural drug delivery carriers were used to load conventional anticancer drug doxorubicin (DOX) and a chemosensitizer lonidamine (LND). Two types of EVs with different sizes (16k EVs and 120k EVs) were prepared using different centrifugation forces. We found that co-delivery of DOX and LND with both EVs enhanced the cytotoxicity and reduced the dose of the anticancer drug significantly in vitro. Effective delivery of anti-cancer drugs to cancer cells was achieved by direct fusion of EVs with the plasma membrane of cancer cells. On the other hand, DOX and LND inhibited cancer cell proliferation by increasing DNA damage, suppressing ATP production, and accelerating ROS generation synergistically. DOX and LND loaded EVs were also applied to the mouse lung cancer model and exhibited significant anticancer activity. In vivo study showed that smaller EVs exhibited higher anticancer efficiency. In conclusion, the co-delivery of the anticancer drug and the chemosensitizer with EVs may have potential clinical applications for cancer therapy.
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一级学科
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Pharmacology & Pharmacy
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WOS入藏号
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WOS:000739359600001
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EI收录号
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DOI
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10.1080/10717544.2021.2023697
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ESI
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收录于
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SCIE
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