英文论文
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文献类型
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Journal article (JA)
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题名
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Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae
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作者
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Shen, Chao; Cai, Yimei; Li, Jialing; He, Chengyong; Zuo, Zhenghong
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作者单位
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[Shen, Chao; Cai, Yimei; Li, Jialing; He, Chengyong; Zuo, Zhenghong] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China. [Zuo, Zhenghong] Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Peoples R China.
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通讯作者地址
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Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China.; Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Peoples R China.
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Email
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zuozhenghong@xmu.edu.cn
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ResearchID
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ORCID
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期刊名称
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Journal of Environmental Sciences (China)
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出版社
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Chinese Academy of Sciences
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ISSN
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1001-0742
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出版信息
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2023-02, 124:76-88.
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JCR
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影响因子
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ISBN
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基金
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National Natural Science Foundation of China [42177411]; Natural Science Foundation of Fujian Province of China [2018J01067]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Genes; Polymerase chain reaction; Toxicity; Vision
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摘要
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Mepanipyrim, an anilinopyrimidine fungicide, has been extensively used to prevent fungal diseases in fruit culture. Currently, research on mepanipyrim-induced toxicity in organisms is still very scarce, especially visual developmental toxicity. Here, zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity. Intense light and monochromatic light stimuli-evoked escape experiments were used to investigate vision-guided behaviors. Meanwhile, transcriptomic sequencing and real-time quantitative PCR assays were applied to assess the potential mechanisms of mepanipyrim-induced visual developmental toxicity and vision-guided behavioral alteration. Our results showed that mepanipyrim exposure could induce retinal impairment and vision-guided behavioral alteration in larval zebrafish. In addition, the grk1b gene of the phototransduction signaling pathway was found to be a potential aryl hydrocarbon receptor (AhR)-regulated gene. Mepanipyrim-induced visual developmental toxicity was potentially related to the AhR signaling pathway. Furthermore, mepanipyrim-induced behavioral alteration was guided by the visual function, and the effects of mepanipyrim on long and middle wavelength light-sensitive opsins may be the main cause of vision-guided behavioral alteration. Our results provide insights into understanding the relationship between visual development and vision-guided behaviors induced by mepanipyrim exposure. ?? 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
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一级学科
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Environmental Sciences
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WOS入藏号
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WOS:000797162500010
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EI收录号
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20220511575565
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DOI
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10.1016/j.jes.2021.11.008
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ESI
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收录于
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SCIE, EI
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