英文论文


文献类型
Journal article (JA)
题名
Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae
作者
Shen, Chao; Cai, Yimei; Li, Jialing; He, Chengyong; Zuo, Zhenghong
作者单位
[Shen, Chao; Cai, Yimei; Li, Jialing; He, Chengyong; Zuo, Zhenghong] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China. [Zuo, Zhenghong] Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Peoples R China.
通讯作者地址
Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China.; Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Peoples R China.
Email
zuozhenghong@xmu.edu.cn
ResearchID
ORCID
期刊名称
Journal of Environmental Sciences (China)
出版社
Chinese Academy of Sciences
ISSN
1001-0742
出版信息
2023-02, 124:76-88.
JCR
影响因子
ISBN
基金
National Natural Science Foundation of China [42177411]; Natural Science Foundation of Fujian Province of China [2018J01067]
会议名称
会议地点
会议开始日期
会议结束日期
关键词
Genes; Polymerase chain reaction; Toxicity; Vision
摘要
Mepanipyrim, an anilinopyrimidine fungicide, has been extensively used to prevent fungal diseases in fruit culture. Currently, research on mepanipyrim-induced toxicity in organisms is still very scarce, especially visual developmental toxicity. Here, zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity. Intense light and monochromatic light stimuli-evoked escape experiments were used to investigate vision-guided behaviors. Meanwhile, transcriptomic sequencing and real-time quantitative PCR assays were applied to assess the potential mechanisms of mepanipyrim-induced visual developmental toxicity and vision-guided behavioral alteration. Our results showed that mepanipyrim exposure could induce retinal impairment and vision-guided behavioral alteration in larval zebrafish. In addition, the grk1b gene of the phototransduction signaling pathway was found to be a potential aryl hydrocarbon receptor (AhR)-regulated gene. Mepanipyrim-induced visual developmental toxicity was potentially related to the AhR signaling pathway. Furthermore, mepanipyrim-induced behavioral alteration was guided by the visual function, and the effects of mepanipyrim on long and middle wavelength light-sensitive opsins may be the main cause of vision-guided behavioral alteration. Our results provide insights into understanding the relationship between visual development and vision-guided behaviors induced by mepanipyrim exposure. ?? 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
一级学科
Environmental Sciences
WOS入藏号
WOS:000797162500010
EI收录号
20220511575565
DOI
10.1016/j.jes.2021.11.008
ESI
收录于
SCIE, EI

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