英文论文


文献类型
Article
题名
Optic nerve gliomas in adults: a SEER-based study
作者
Lin, Xiaoning; Huang, Rong; Su, Jinyun; Li, Heng; Liu, Zhong; Zhang, Pengfei; Tian, Xinhua
作者单位
[Lin, Xiaoning; Li, Heng; Liu, Zhong; Tian, Xinhua] Xiamen Univ, Zhongshan Hosp, Sch Med, Dept Neurosurg, Xiamen 361004, Peoples R China. [Huang, Rong] Xiamen Univ, Women & Childrens Hosp, Sch Med, Dept Child Hlth, Xiamen, Peoples R China. [Su, Jinyun] Nanan City Hosp, Dept Anesthesiol, Quanzhou, Peoples R China. [Zhang, Pengfei] Anhui Med Univ, Dept Infect Dis, Affiliated Hosp 1, Hefei, Peoples R China.
通讯作者地址
Xiamen Univ, Zhongshan Hosp, Sch Med, Dept Neurosurg, Xiamen 361004, Peoples R China.
Email
linxn107@163.com; txhmd@163.com
ResearchID
ORCID
期刊名称
ALL LIFE
出版社
TAYLOR & FRANCIS LTD
ISSN
2689-5293
出版信息
2022-12-31, 15 (1):262-269.
JCR
影响因子
ISBN
基金
Joint research project of Science and Technology Bureau and Health Commission of Xiamen [3502Z20179046]; Joint Fund Science and Technology Department and Health Commission of Fujian Province [2019J01562]; Natural Science Foundation of Anhui ProvinceNatural Science Foundation of Anhui Province [2008085QH383]
会议名称
会议地点
会议开始日期
会议结束日期
关键词
Optic nerve glioma; adults; prognosis; adjuvant therapy; SEER
摘要
Introduction: Optic nerve gliomas (ONGs) are uncommon tumors of the central nervous system in adults. The aim of this study was to define their characteristics, prognostic factors, and the impacts of adjuvant radiotherapy (RT) and chemotherapy on outcomes. Methods: Adult patients (age >= 18 years) with ONGs from the Surveillance, Epidemiology, and End Results (SEER) database were included. Univariate and multivariate Cox regression models were utilized to analyze the factors associated with survival. Kaplan-Meier method was used to evaluate the impacts of adjuvant therapies on overall survival (OS). Results: A total of 179 adult patients diagnosed with ONGs were identified between 1991 and 2016, with a median follow-up period of 64.0 months. Multivariate analysis showed age at diagnosis, tumor grade, adjuvant chemotherapy were significant factors for OS. The employment of adjuvant RT or chemotherapy significantly shortened OS time in the low-grade group and could not prolong OS time in the high-grade group. Conclusions This is the largest retrospective study of adult ONGs up to date. The overall prognosis of high-grade ONGs in adult patients is still poor despite multi-modality treatments. Adjuvant RT or chemotherapy should be applied cautiously before full clinical evaluation in adult patients with low-grade ONGs.
一级学科
Multidisciplinary Sciences
WOS入藏号
WOS:000762664800001
EI收录号
DOI
10.1080/26895293.2022.2046180
ESI
收录于
SCIE

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