英文论文
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文献类型
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Article
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题名
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Acacetin alleviates myocardial ischaemia/reperfusion injury by inhibiting oxidative stress and apoptosis via the Nrf-2/HO-1 pathway
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作者
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Wu, Chan; Chen, Ruo-Lan; Wang, Yan; Wu, Wei-Yin; Li, Gang
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作者单位
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[Wu, Chan; Chen, Ruo-Lan; Wang, Yan; Wu, Wei-Yin; Li, Gang] Xiamen Univ, Xiamen Cardiovasc Hosp, Sch Med, Inst Cardiovasc Res, Xiamen, Fujian, Peoples R China.
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通讯作者地址
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Xiamen Univ, Xiamen Cardiovasc Hosp, Xiamen 361015, Fujian, Peoples R China.
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Email
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wuweiyin@xmheart.com; ligang@xmu.edu.cn
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ResearchID
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ORCID
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期刊名称
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PHARMACEUTICAL BIOLOGY
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出版社
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TAYLOR & FRANCIS LTD
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ISSN
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1388-0209
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出版信息
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2022-12-31, 60 (1):553-561.
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JCR
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影响因子
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ISBN
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基金
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National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1605226]; Science and Technology Project from Xiamen Science and Technology Bureau, Fujian Province, China [3502Z20184025, 3502Z20184024]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Ventricular premature; ventricular tachycardia; ventricular fibrillation; SOD1; collagen; Bax; Bcl-2; TLR4; IL-6; inflammation
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摘要
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Context Acacetin is a natural source of flavonoids with anti-inflammatory and antioxidant effects. Objective This study determines acacetin's protective effect and mechanism on myocardial ischaemia/reperfusion (I/R) injury. Materials and methods Sprague-Dawley rats were divided into sham and I/R injury and treatment with acacetin. Acacetin (10 mg/kg) was subcutaneously injected for 7 days. ECG and echocardiography were conducted to determine arrhythmia and heart function. The pathological characters of the heart were determined with triphenyl tetrazolium chloride staining, Haematoxylin & Eosin staining, and Masson staining. Expression of proteins in infarct tissues was examined with western blots. Results Administrated with acacetin in I/R rats significantly reduced the arrhythmia score from 4.90 to 2.50 and the reperfusion arrhythmia score from 3.79 to 1.82 in the vehicle or the acacetin group, respectively. LVEF was improved from 33.5% in the I/R group to 43.7% in the acacetin group, LVFS was increased from 16.4% to 24.5%, LVIDs was decreased from 6.5 to 5.3 mm. The inflammatory cell infiltration, myocardial fibrosis, and collagen 1 and 3 were reduced by acacetin. Acacetin promoted SOD and decreased MDA. In myocardial tissues, the expression level of TLR4 and IL-6 were restrained, and IL-10 was promoted. Apoptotic protein Bax was suppressed, and anti-apoptotic protein Bcl-2 was promoted in the acacetin group. Interestingly, the transcription factor Nrf-2/HO-1 pathway was also reversed by acacetin. Discussion and conclusion Our findings indicated that acacetin has a potential therapeutic effect in clinical application on treating I/R-induced heart injury.
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一级学科
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Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
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WOS入藏号
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WOS:000764365500001
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EI收录号
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DOI
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10.1080/13880209.2022.2041675
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ESI
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收录于
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SCIE
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