英文论文
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文献类型
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Article
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题名
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A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
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作者
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Wang, Xin; Yin, Xiaochen; Zhang, Boya; Liu, Chenfeng; Lin, Yahua; Huang, Xiaofen; Li, Yufang; Shen, Chenguang; Zheng, Weibin; Fu, Guofeng; Chen, Junyu; Wen, Yanling; Zhang, Wei; Pan, Bo-Sheng; Fang, Mujin; Zheng, Zizheng; Zhang, Zheng; Yuan, Quan; Fu, Guo; Li, Shaowei; Zhang, Jun; Chen, Yixin; Xia, Ningshao; Zhao, Qinjian
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作者单位
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[Wang, Xin; Yin, Xiaochen; Zhang, Boya; Lin, Yahua; Huang, Xiaofen; Li, Yufang; Shen, Chenguang; Chen, Junyu; Zhang, Wei; Fang, Mujin; Zheng, Zizheng; Yuan, Quan; Li, Shaowei; Zhang, Jun; Chen, Yixin; Xia, Ningshao; Zhao, Qinjian] Xiamen Univ, Sch Publ Hlth, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China. [Wang, Xin; Wen, Yanling; Zhang, Zheng] Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Inst Hepatol, Shenzhen Peoples Hosp 3, Shenzhen, Peoples R China. [Wang, Xin; Wen, Yanling; Zhang, Zheng] Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen, Peoples R China. [Zheng, Weibin; Fu, Guofeng; Fu, Guo] Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China. [Liu, Chenfeng] Anhui Med Univ, Sch Life Sci, Dept Cell Biol, Hefei, Peoples R China. [Zhao, Qinjian] Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China. [Pan, Bo-Sheng] Reverie Labs, Cambridge, MA USA.
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通讯作者地址
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Xiamen Univ, Sch Publ Hlth, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China.; Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Inst Hepatol, Shenzhen Peoples Hosp 3, Shenzhen, Peoples R China.; Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen, Peoples R China.; Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China.
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Email
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xin.wang.xmu@qq.com; yxchen2008@xmu.edu.cn; nsxia@xmu.edu.cn; zhaoqinjian@xmu.edu.cn
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ResearchID
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ORCID
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期刊名称
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EMERGING MICROBES & INFECTIONS
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出版社
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TAYLOR & FRANCIS LTD
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ISSN
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出版信息
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2022-12-31, 11 (1):914-925.
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JCR
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影响因子
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ISBN
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基金
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National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [32070925, 82041038]; National Key Research and Development Programs of China [2020YFC0842600]; Guangdong Provincial Department of Science and Technology [2020B1111340033]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Prophylactic; influenza; respiratory syncytial virus; alveolar macrophage; interferon
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摘要
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Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses.
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一级学科
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Immunology; Infectious Diseases; Microbiology
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WOS入藏号
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WOS:000773723600001
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EI收录号
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DOI
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10.1080/22221751.2022.2050951
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ESI
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收录于
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SCIE
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