Targeting the PHF8/YY1 axis suppresses cancer cell growth through modulation of ROS

Enantioselective transformation of phytoplankton-derived dihydroxypropanesulfonate by marine bacteria

6-Plex Tandem Phosphorus Tags (TPT) for Accurate Quantitative Proteomics

Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation

Identification and characterization of 7-azaindole derivatives as inhibitors of the SARS-CoV-2 spike-hACE2 protein interaction

Isobaric Stable Isotope N-Phosphorylation Labeling (iSIPL) for Ultrasensitive Proteome Quantification

Isobaric Stable Isotope N-Phosphorylation Labeling (iSIPL) for Ultrasensitive Proteome Quantification

The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9

Discovering a New Okadaic Acid Derivative, a Potent HIV Latency Reversing Agent from <i>Prorocentrum lima</i> PL11: Isolation, Structural Modification, and Mechanistic Study

Comprehensive Profiling of Amine-Containing Metabolite Isomers with Chiral Phosphorus Reagents

Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma

Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier

Prebiotic Formation of Catalytically Active Dipeptides via Trimetaphosphate Activation

Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage

A natural product targets BRD4 to inhibit phase separation and gene transcription

Asymmetric Total Synthesis of Shizukaol J, Trichloranoid C and Trishizukaol A

Metabolism of chiral sulfonate compound 2,3-dihydroxypropane-1-sulfo-nate (DHPS) by Roseobacter bacteria in marine environment

Stand out from matrix: Ultra-sensitive LC-MS/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth

Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury

Resveratrol Promotes HIV-1 Tat Accumulation via AKT/FOXO1 Signal-ing Axis and Potentiates Vorinostat to Antagonize HIV-1 Latency

A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor alpha-dependent transcriptional activation and breast carcinogenesis

Intermolecular Ligand Exchange of Penta-oxy Phosphoranes: Potential Chemical Model for RNA Hydrolysis and Fusion

The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency

Methylation of transcription factor YY2 regulates its transcriptional activity and cell proliferation

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

Stable isotope N-phosphoryl amino acids labeling for quantitative profiling of amine-containing metabolites using liquid chromatography mass spectrometry

Novel tandem hydrogen migrations across five chemical bonds for 1,4-dihydropyridine using electrospray ionization FT-ICR mass spectrometry

Chinese Pediatric Organ Donation With Scheduled Cardiac Arrest After Brain Death: A Novel China Classification Beyond Maastricht

A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP

Arginine methylation of HSP70 regulates retinoid acid-mediated RAR beta 2 gene activation

Reactivity of Germylene toward Phosphorus-Containing Compounds: Nucleophilic Addition and Tautomerism

Mass spectrometry-based method to investigate the natural selectivity of sucrose as the sugar transport form for plants

N-phosphoryl amino acid models for P-N bonds in prebiotic chemical evolution

Specific interactions of leucine with disaccharides by electrospray ionization mass spectrometry: application to rapid differentiation of disaccharide isomers in combination with statistical analysis

Cleavage of phosphorus-carbon (P-C) bonds of α-amino phosphonates with intramolecular hydrogen migration in the gas phase using electrospray ionization tandem mass spectrometry

A novel quantification method for analysis of twenty natural amino acids in human serum based on N-phosphorylation labeling using reversed-phase liquid chromatography-tandem mass spectrometry

Mechanism, Reactivity, and Selectivity in Rh(III)-Catalyzed Phosphoryl-Directed Oxidative C-H Activation/Cyclization: A DFT Study

Using positive-ion electrospray ionization mass spectrometry and H/D exchange study phosphoryl group transfer reactions involved in amino acid ester isopropyl phosphoramidates of Brefeldin A

Double role of the hydroxy group of phosphoryl in palladium(II)-catalyzed ortho -olefination: A combined experimental and theoretical investigation

Experimental and theoretical studies on nickel-zinc-catalyzed cross-coupling of gem-dibromoalkenes with P(O)-H compounds