COVID-19 vaccines and beyond

50 years ago, cell biology was a nascent field. Today, it is a vast discipline whose principles and tools are also applied to other disciplines; vice versa, cell biologists are inspired by other fields. So, the question begs: what is cell biology? The answers are as diverse as the people who define it.

Optimal tagging strategies for illuminating expression profiles of genes with different abundance in zebrafish

Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death

Fluorescence-On Imaging of Reticulophagy Enabled by an Acidity-Reporting Solvatochromic Probe

Dear-DIAXMBD: Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics

Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker

A p38 alpha-BLIMP1 signalling pathway is essential for plasma cell differentiation

Rethinking sepsis after a two-year battle with COVID-19

<p>MSSort-DIA(XMBD): A deep learning classification tool of the peptide precursors quantified by OpenSWATH</p>

INFLAMMASOME Dual ligand engagement for noncanonical inflammasome activation

Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death

Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina

DAISM-DNNXMBD: Highly accurate cell type proportion estimation with in silico data augmentation and deep neural networks

Imaging of Mitophagy Enabled by an Acidity-Reporting Probe Anchored on the Mitochondrial Inner Membrane

An organelle-directed chemical ligation approach enables dual-color detection of mitophagy

RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes

In cellulo synthesis of dendrimeric sensors for fluorescence-on imaging of bacterial phagocytosis

Installation of high-affinity Siglec-1 ligand on tumor surface for macrophage-engaged tumor suppression

Deep representation features from DreamDIA(XMBD) improve the analysis of data-independent acquisition proteomics

NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Dice-XMBD: Deep Learning-Based Cell Segmentation for Imaging Mass Cytometry

Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5

Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA

The essential role of PRAK in tumor metastasis and its therapeutic potential

RNA N-6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m(6)A-GLUT1-mTORC1 Axis and Is a Therapeutic Target

Organelle-Directed Metabolic Glycan Labeling and Optical Tracking of Dysfunctional Lysosomes Thereof

A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

Macrophage p38 alpha promotes nutritional steatohepatitis through M1 polarization (vol 71, pg 163, 2019)

The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

Gut stem cell necroptosis by genome instability triggers bowel inflammation

ZBP1 mediates interferon-induced necroptosis

Generation of a murine SWATH-MS spectral library to quantify more than 11,000 proteins

Systematic Assessment of the Effect of Internal Library in Targeted Analysis of SWATH-MS

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure

Pathological function of caecum epithelial cell necroptosis

An in cellulo-activated multicolor cell labeling approach used to image dying cell clearance

Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes

Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS

High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice

Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport

Organelle-Redirected Chameleon Sensor-Enabled Live Cell Imaging of Mitochondrial DNA

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

On the use of abiotic sialic acids to attenuate cell inflammation

Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe

miR-30 disrupts senescence and promotes cancer by targeting both p16(INK4A) and DNA damage pathways

Bioorthogonal Conjugation Directed by a Sugar-Sorting Pathway for Continual Tracking of Stressed Organelles

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis

p38 alpha has an important role in antigen cross-presentation by dendritic cells

Organelle-Directed Staudinger Reaction Enabling Fluorescence-on Resolution of Mitochondrial Electropotentials via a Self-Immolative Charge Reversal Probe

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Plasma membrane changes during programmed cell deaths

Bifunctional Super-resolution Imaging Probe with Acidity-Independent Lysosome-Retention Mechanism

Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation (vol 35, pg 1700, 2015)

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

Defining Cancer Cell Bioenergetic Profiles Using a Dual Organelle-Oriented Chemosensor Responsive to pH Values and Electropotential Changes

The RIP3-RIP1-NF-kappa B signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8(+) T cells

The transcriptional coactivator TAZ regulates reciprocal differentiation of T(H)17 cells and T-reg cells

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter

Imaging Lysosomal pH Alteration in Stressed Cells with a Sensitive Ratiometric Fluorescence Sensor

The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis

Differential Sensitivity of Target Genes to Translational Repression by miR-17 similar to 92

Responsive hetero-organelle partition conferred fluorogenic sensing of mitochondrial depolarization

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

MicroRNA-17 similar to 92 inhibits colorectal cancer progression by targeting angiogenesis

The Necrosome in Acute Kidney Injury

Redirecting immunity: Via covalently incorporated immunogenic sialic acid on the tumor cell surface

Gasdermin D is an executor of pyroptosis and required for interleukin-1 beta secretion

Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files

A Role for Tubular Necroptosis in Cisplatin-Induced AKI

TCR-induced sumoylation of the kinase PKC-theta controls T cell synapse organization and T cell activation

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA

Optical Tracking of Phagocytosis with an Activatable Profluorophore Metabolically Incorporated into Bacterial Peptidoglycan

Lysosomal pH Decrease in Inflammatory Cells Used To Enable Activatable Imaging of Inflammation with a Sialic Acid Conjugated Profluorophore

A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging

A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU

Centrifugation aided highly sensitive detection of nitrite with a dye-silica conjugate featuring cleavable linkages

Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress

Regulator of G-Protein Signaling 19 (RGS19) and Its Partner G alpha-Inhibiting Activity Polypeptide 3 (GNAI3) Are Required for zVAD-Induced Autophagy and Cell Death in L929 Cells

The G beta gamma-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation

AMP-activated Protein Kinase alpha 2 Protects against Liver Injury from Metastasized Tumors via Reduced Glucose Deprivation-induced Oxidative Stress

HBV life cycle is restricted in mouse hepatocytes expressing human NTCP

Quantitative phosphoproteomic analysis of RIP3-dependent protein phosphorylation in the course of TNF-induced necroptosis

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Dimeric structure of p300/CBP associated factor

A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

A fluorescently labelled sialic acid for high performance intraoperative tumor detection

A photothermal cell viability-reporting theranostic nanoprobe for intraoperative optical ablation and tracking of tumors

A rhodamine-benzimidazole based sensor for selective imaging of acidic pH

A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors

The p38-Interacting protein (p38IP) regulates G2/M progression by promoting α-Tubulin acetylation via inhibiting ubiquitination-Induced degradation of the acetyltransferase GCN5

Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation

Rhodamine-propargylic esters for detection of mitochondrial hydrogen sulfide in living cells

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

Activation of p38 alpha in T Cells Regulates the Intestinal Host Defense against Attaching and Effacing Bacterial Infections

Traceless protein delivery with an efficient recyclable nanocarrier

Benzothiazoline based chemodosimeters for fluorogenic detection of hypochlorous acid

A Potential Suppressive Effect of Natural Antisense IL-1 beta RNA on Lipopolysaccharide-Induced IL-1 beta Expression

Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling

Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response

RIP3 is involved in host defense against HSV-1 infection via enhancing STING mediated antiviral signaling

Gene Deletion of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses

The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

COP1 and GSK3 beta Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

A self-referenced nanodosimeter for reaction based ratiometric imaging of hypochlorous acid in living cells

Resolution of lysosomes in living cells with a ratiometric molecular pH-meter

Investigation of Receptor interacting protein (RIP3)-dependent Protein Phosphorylation by Quantitative Phosphoproteomics

New components of the necroptotic pathway

Rhodamine-deoxylactam functionalized poly[styrene-alter-(maleic acid)]s as lysosome activatable probes for intraoperative detection of tumors

Cytosolic delivery of proteins mediated by aldehyde-displaying silica nanoparticles with pH-responsive characteristics

Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct

Covalent labeling of mitochondria with a photostable fluorescent thiol-reactive rhodamine-based probe

PRAK Suppresses Oncogenic ras-Induced Hematopoietic Cancer Development by Antagonizing the JNK Pathway

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Dietary Mustard Seeds (Sinapis alba Linn) Suppress 1,2-Dimethylhydrazine-Induced Immuno-Imbalance and Colonic Carcinogenesis in Rats

A Novel Function of p38-Regulated/Activated Kinase in Endothelial Cell Migration and Tumor Angiogenesis

Determinants of public T cell responses

MLK4 has negative effect on TLR4 signaling

Fluorogenic detection of hydrogen sulfide via reductive unmasking of o-azidomethylbenzoyl-coumarin conjugate

Programmed necrosis: backup to and competitor with apoptosis in the immune system

Phosphorylation of Raptor by p38 beta Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation

AMPD3 is involved in anthrax LeTx-induced macrophage cell death

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

Multiple death pathways in TNF-treated fibroblasts: RIP3-and RIP1-dependent and independent routes

Imaging of intracellular acidic compartments with a sensitive rhodamine based fluorogenic pH sensor

Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity

Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor featuring an intramolecular deoxylactam

Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding

Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi

The miR-17-92 Cluster of MicroRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence

Receptor-interacting protein (RIP) kinase family

Epithelial p38 alpha Controls Immune Cell Recruitment in the Colonic Mucosa

p38 gamma regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage

Specific Regulation of Noncanonical p38 alpha Activation by Hsp90-Cdc37 Chaperone Complex in Cardiomyocyte

MAPK signaling in inflammation-associated cancer development

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

P38 and p38 mediate oncogenic ras-induced senescence through differential mechanisms

Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates

Inflammatory signaling and cellular senescence

Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}

TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization

Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice

Determinants that control the distinct subcellular localization of p38-PRAK and p38-PRAK complexes

Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor-induced apoptosis of MCF-7 cells

The pathways to tumor suppression via route p38

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by Aida

Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression

PRAK is essential for ras-induced senescence and tumor suppression

Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

Determinants that control the specific interactions between TAB1 and p38 alpha

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Nod1-dependent control of tumor growth

Limiting inflammatory responses during activation of innate immunity

Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells

Frequency and distribution of AP-1 sites in the human genome

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

Functional proteome related to MAPK kinases in 293T cells

beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation