Human ApoE2 protects mice against <i>Plasmodium berghei</i> ANKA experimental cerebral malaria

Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination

Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis

Discovery of urea-based pleuromutilin derivatives as potent gram-positive antibacterial agents

Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strategy

Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms

Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens

PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron

The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents

Pharmacological targeting PIKfyve and tubulin as an effective treatment strategy for double-hit lymphoma

Ddb1 Is Essential for the Expansion of CD4(+) Helper T Cells by Regulating Cell Cycle Progression and Cell Death

Discovery of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl )-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d] pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

Blocking PPAR gamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility

Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition

Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases

Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis

Close-loop dynamic nanohybrids on collagen-ark with: In situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities

Genome Sequencing Reveals the Complex Polysaccharide-Degarding Ability of Novel Deep-Sea Bacterium Flammeovirga Pacifica WPAGA1

Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway

Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors

Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis

The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling