ErbB3 is required for hyperaminoacidemia-induced pancreatic a cell hyperplasia

Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of <i>Agathis dammara</i>

Unique Advantages of Dendrimers-Structured Mesoporous Silica Nanoparticles over Traditional Hollow Ones in Delivering Bcl2-Functional Converting Peptide for Multidrug Resistant Cancer Treatment

The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma

FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium

A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus <i>Pallidocercospora crystalline</i>

Crispr-Cas9 mediated complete deletion of glucagon receptor in mice display hyperglucagonemia and a-cell hyperplasia

Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation

Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77

Disruption of the glucagon receptor increases glucagon expression beyond alpha-cell hyperplasia in zebrafish

Novel Loss-of-Function Variant in HNF1a Induces beta-Cell Dysfunction through Endoplasmic Reticulum Stress

Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXR alpha-targeted anti-mitotic agents

Identification of MRAP protein family as broad-spectrum GPCR modulators

Cynarin inhibits PDGF-BB-induced proliferation and activation in hepatic stellate cells through PPAR gamma

Integrated approach toward absorption, distribution, metabolism, and excretion of Xiaoke pills in zebrafish based on UPLC-HRMS and DESI-MS techniques

Brasilterpenes A-E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135

Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish

New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8

Artemether and aspterric acid induce pancreatic alpha cells to transdifferentiate into beta cells in zebrafish

Instantaneous Phosphatidylcholine spatial specific regulation induced by formononetin revealed by DESI-MSI

Linear polyketides produced by co-culture of Penicillium crustosum and Penicillium fellutanum

IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish

Impact of macroporous silica nanoparticles at sub-50nm on bio-behaviors and biosafety in drug-resistant cancer models

Penipyrols C-G and methyl-penipyrol A, alpha-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131

Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor-Deficient Zebrafish

Two new compounds from a mangrove sediment-derived fungus Penicillium polonicum H175

Staprexanthones, Xanthone-Type Stimulators of Pancreatic beta-Cell Proliferation from a Mangrove Endophytic Fungus

Characterization of Insulin and Glucagon Genes and Their Producing Endocrine Cells From Pygmy Sperm Whale (Kogia breviceps)

Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety

Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment

Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network

SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38 alpha MAPK

Interrupted Glucagon Signaling Reveals Hepatic alpha Cell Axis and Role for L-Glutamine in alpha Cell Proliferation

Zebrafish Genome Engineering Using the CRISPR-Cas9 System