AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

ELP3 stabilizes c-Myc to promote tumorigenesis

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC

Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

Meet the authors: Bin Jiang and Qinxi Li

Metabolomics and its Applications in Cancer Cachexia

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

c-Src facilitates tumorigenesis by phosphorylating and activating G6PD

ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM

c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3

NMR-based metabonomic analysis of HUVEC cells during replicative senescence

IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter

IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

C-terminus of MUC16 activates Wnt signaling pathway through its interaction with beta-catenin to promote tumorigenesis and metastasis

MDM2 Inhibits Axin-Induced p53 Activation Independently of Its E3 Ligase Activity

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Molecular Basis of Wnt Activation via the DIX Domain Protein Ccd1

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

Cytosporone B is an agonist for nuclear orphan receptor Nur77

Protein encoded by the AxinFu allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling

Determinants that control the distinct subcellular localization of p38-PRAK and p38-PRAK complexes

Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Nod1-dependent control of tumor growth

Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death