已发表成果:
WOK 论文 128 篇;中文核心 67 篇;其它论文 17 篇;专利发明 22 个;
Structural insights into activation mechanisms on NADase of the bacterial DSR2 anti-phage defense system
A cryptic site in class 5 epitope of SARS-CoV-2 RBD maintains highly conservation across natural isolates
Comprehensive Overview of Broadly Neutralizing Antibodies against SARS-CoV-2 Variants
Risedronate-functionalized manganese-hydroxyapatite amorphous particles: A potent adjuvant for subunit vaccines and cancer immunotherapy
Rational design of a cross-type HPV vaccine through immunodominance shift guided by a cross-neutralizing antibody
Empirical validation of ProteinMPNN's efficiency in enhancing protein fitness
Micronanoparticled risedronate exhibits potent vaccine adjuvant effects
Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions
In-depth review of delivery carriers associated with vaccine adjuvants: current status and future perspectives
Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection
Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
Structure and proposed DNA delivery mechanism of a marine roseophage
Precision and correlation of ED50 and endpoint titer method in measuring HPV vaccine immunogenicity
Design of Multicomponent Peptide Fibrils with Ordered and Programmable Compositional Patterns
Design of Multicomponent Peptide Fibrils with Ordered and Programmable Compositional Patterns
Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16
Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for <i>Escherichia coli</i>-based vaccine design
A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine
Current progress in the development of prophylactic and therapeutic vaccines
Omics-guided bacterial engineering of Escherichia coli ER2566 for recombinant protein expression
Efficacy, safety, and immunogenicity of an Escherichia coli-produced Human Papillomavirus (16 and 18) L1 virus-like-particle vaccine: end-of-study analysis of a phase 3, double-blind, randomised, controlled trial
Characterization of an Escherichia coli-derived triple-type chimeric vaccine against human papillomavirus types 39, 68 and 70
A bacterially expressed triple-type chimeric vaccine against human papillomavirus types 51, 69, and 26
Genetic engineering of baculovirus-insect cell system to improve protein production
A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode
Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail
Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses
Endodomain truncation of the HIV-1 envelope protein improves the packaging efficiency of pseudoviruses
The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2
Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion
Baculovirus Display of Varicella-Zoster Virus Glycoprotein E Induces Robust Humoral and Cellular Immune Responses in Mice
Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron
A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo
A Bacterially Expressed SARS-CoV-2 Receptor Binding Domain Fused With Cross-Reacting Material 197 A-Domain Elicits High Level of Neutralizing Antibodies in Mice
Structures of pseudorabies virus capsids
Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209
Pre-existing maternal IgG antibodies as a protective factor against congenital cytomegalovirus infection: A mother-child prospective cohort study
A stepwise docking molecular dynamics approach for simulating antibody recognition with substantial conformational changes
Engineering for an HPV 9-valent vaccine candidate using genomic constitutive over-expression and low lipopolysaccharide levels in Escherichia coli cells
Nanospheres from coordination polymers of Ag+ with a highly hydrophilic thiol ligand formed in situ from dynamic covalent binding and a hydrophobic thiol
Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters
In situ analysis of biomolecular interactions on nano/microparticles in formulations
Structural Basis for the Shared Neutralization Mechanism of Three Classes of Human Papillomavirus Type 58 Antibodies with Disparate Modes of Binding
Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating
The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis
Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids
Comprehensive Assessment of the Antigenic Impact of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised against Lineage A Major Capsid Proteins of Vaccine-Related Genotypes
Structural characterization of a neutralizing mAb H16.001, a potent candidate for a common potency assay for various HPV16 VLPs
Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans
Structure guided maturation of a novel humanized anti-HBV antibody and its preclinical development
Functional epitopes on hepatitis E virions and recombinant capsids are highly conformation-dependent
Genome re-sequencing and reannotation of the Escherichia coli ER2566 strain and transcriptome sequencing under overexpression conditions
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
Recent Progress on the Versatility of Virus-Like Particles
Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16
A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice
Efficacy, Safety, and Immunogenicity of an Escherichia coli-Produced Bivalent Human Papillomavirus Vaccine: An Interim Analysis of a Randomized Clinical Trial
SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates
Demonstration of real-time and accelerated stability of hepatitis E vaccine with a combination of different physicochemical and immunochemical methods
Prophylactic Hepatitis E Vaccines: Antigenic Analysis and Serological Evaluation
Viral neutralization by antibody-imposed physical disruption
Simultaneous in situ visualization and quantitation of dual antigens adsorbed on adjuvants using high content analysis
Altered antigenicity and immunogenicity of human papillomavirus virus-like particles in the presence of thimerosal
Construction of a bacterial surface display system based on outer membrane protein F
Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A
Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells
Impact of naturally occurring variation in the human papillomavirus 52 capsid proteins on recognition by type-specific neutralising antibodies
Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
T=4 Icosahedral HIV-1 Capsid As an Immunogenic Vector for HIV-1 V3 Loop Epitope Display
Multifaceted characterization of recombinant protein-based vaccines: An immunochemical toolbox for epitope-specific analyses of the hepatitis E vaccine
Impact of Naturally Occurring Variation in the Human Papillomavirus 58 Capsid Proteins on Recognition by Type-Specific Neutralizing Antibodies
Epitope clustering analysis for vaccine-induced human antibodies in relationship to a panel of murine monoclonal antibodies against HPV16 viral capsid
N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro
Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10
Identification of Strategic Residues at the Interface of Antigen-Antibody Interactions by In Silico Mutagenesis
Characterization of capsid protein (p495) of hepatitis E virus expressed ID in Escherichia coli and assembling into particles in vitro
Expression, Purification and Characterization of Hiv-1 Capsid Precursor Protein p41
Characterization and epitope mapping of a panel of monoclonal antibodies against HIV-1 matrix protein
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Characterization of an Escherichia coil-derived human papillomavirus type 16 and 18 bivalent vaccine
Bacterially expressed human papillomavirus type 6 and 11 bivalent vaccine: Characterization, antigenicity and immunogenicity
A novel combined vaccine based on monochimeric VLP co-displaying multiple conserved epitopes against enterovirus 71 and varicella-zoster virus
Stop codon mutagenesis for homogenous expression of human papillomavirus L1 protein in Escherichia coli
Real-time stability of a hepatitis E vaccine (Hecolin (R)) demonstrated with potency assays and multifaceted physiochemical methods
Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies
A shared N-terminal hydrophobic tail for the formation of nanoparticulates
Quantitative and epitope-specific antigenicity analysis of the human papillomavirus 6 capsid protein in aqueous solution or when adsorbed on particulate adjuvants
The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction
Production of Influenza Virus HA1 Harboring Native-Like Epitopes by Pichia pastoris
Functional assessment and structural basis of antibody binding to human papillomavirus capsid
A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5
Prophylaxis against hepatitis E: at risk populations and human vaccines
Virus-mimetic nanovesicles as a versatile antigen-delivery system
Molecular insights into the inhibition of HIV-1 infection using a CD4 domain-1-specific monoclonal antibody
Immunogenicity and safety of an E. coli-produced bivalent human papillomavirus (type 16 and 18) vaccine: A randomized controlled phase 2 clinical trial
Robust manufacturing and comprehensive characterization of recombinant hepatitis E virus-like particles in Hecolin (R)
Bacteria expressed hepatitis E virus capsid proteins maintain virion-like epitopes
Improved characteristics and protective efficacy in an animal model of E-coli-derived recombinant double-layered rotavirus virus-like particles
Toward the development of monoclonal antibody-based assays to probe virion-like epitopes in hepatitis B vaccine antigen
Virus-like particle-based human vaccines: Quality assessment based on structural and functional properties
Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly
Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts
Antigenic determinants of hepatitis E virus and vaccine-induced immunogenicity and efficacy
Development of the Hepatitis E Vaccine: From Bench to Field
Hepatitis E virus: neutralizing sites, diagnosis, and protective immunity
The enhancement of RNAi against HIV in vitro and in vivo using H-2K(k) protein as a sorting method
Structural and biophysical characterization of Mycobacterium tuberculosis dodecin Rv1498A
Structural basis for the neutralization and genotype specificity of hepatitis E virus
Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78
Dimerization of Hepatitis E Virus Capsid Protein E2s Domain Is Essential for Virus-Host Interaction
Cytosporone B is an agonist for nuclear orphan receptor Nur77
Variants of green fluorescent protein GFPxm
Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid
Alkaline unfolding and salt-induced folding of yeast alcohol dehydrogenase under high pH conditions
疫苗的结构基础和分子设计
厦门大学学报(自然科学版),0438-0479,2024-05-28.假病毒包装系统发展及新兴应用
病毒学报,1000-8721,2024-05-11.HIV-1广谱中和抗体筛选技术的研究进展
中国生物工程杂志,1671-8135,2023-06-15.人免疫缺陷病毒广谱中和抗体的研究进展
中国生物制品学杂志,1004-5503,2023-02-17.HIV-1 Env免疫原设计的研究进展
中国艾滋病性病,1672-5662,2022-05-24.《人乳头瘤病毒疫苗的研究进展》(百年校庆专辑)回顾
厦门大学学报(自然科学版),0438-0479,2022-05-10.人乳头瘤病毒疫苗的研究进展
厦门大学学报(自然科学版),0438-0479,2021-03-28.大肠杆菌表达系统在基因工程疫苗研发中的应用与策略优化
中国新药杂志,1003-3734,2020-11-15.双价人乳头瘤病毒疫苗(大肠杆菌)的有效性研究:一项随机对照临床试验的中期分析
中国妇产科临床杂志,1672-1861,2020-11-15.疫苗免疫原的研究进展和趋势
中国科学基金,1000-8217,2020-10-25.细菌糖基化基本元件及其应用研究进展
微生物学报,0001-6209,2020-08-07.质粒转染比例对人乳头瘤病毒16/18型假病毒制备的影响
病毒学报,1000-8721,2020-06-08.人乳头瘤病毒治疗性疫苗的研究进展
病毒学报,1000-8721,2020-02-13.疫苗技术的研究进展和分析
中国新药杂志,1003-3734,2019-07-30.HIV-1 Env三聚体抗原改造研究进展
生物工程学报,1000-3061,2019-06-18.HIV-1 Env三聚体抗原改造研究进展
生物工程学报,1000-3061,2019-06-18.水痘-带状疱疹病毒糖蛋白gE在昆虫细胞中的表达鉴定及其晶体培养
中国病原生物学杂志,1673-5234,2019-05-30.昆虫杆状病毒表达载体系统在疫苗研究中的应用进展
生物工程学报,1000-3061,2019-04-25.人乳头瘤病毒致癌蛋白E6的结构与功能研究进展
病毒学报,1000-8721,2019-03-06.HIV-1近膜端表位及其免疫原设计的研究进展
中国病原生物学杂志,1673-5234,2018-9-30.人乳头瘤病毒中和表位及抗体中和作用机制的研究进展
病毒学报,1000-8721,2018-8-24.基于人乳头瘤病毒次要衣壳蛋白L2的广谱疫苗研究进展
病毒学报,1000-8721,2018-8-24.人CD4胞外区蛋白在杆状病毒-昆虫细胞系统中的表达纯化及性质鉴定
中国免疫学杂志,1000-484X,2018.人乳头瘤病毒样颗粒组装研究进展
病毒学报,1000-8721,2018.HIV-1 CAP2NC蛋白的表达及体外自组装
生物工程学报,1000-3061,2018.三色混合荧光HPV假病毒中和检测系统的建立及评价
中华预防医学杂志,0253-9624,2018.流感病毒M2 e与白喉毒素无毒突变体CRM197融合蛋白的抗原性和免疫原性分析
病毒学报,1000-8721,2017.人类免疫缺陷病毒1型gp140包膜蛋白三聚体在哺乳动物细胞中的高效表达及其性质鉴定
病毒学报,1000-8721,2017.HIV-1糖蛋白gpl20在昆虫细胞中的表达、纯化、性质鉴定以及免疫原性分析
中华微生物学和免疫学杂志,0254-5101,2017.计算机模拟预测治疗性抗体聚集倾向性的进展及应用
中国医药工业杂志,1001-8255,2017.戊型肝炎病毒衣壳蛋白及其中和表位的结构研究进展
中国人兽共患病学报,1002-2694,2016-09-15.悬浮驯化HEK-293FT细胞表达人乳头瘤病毒16型假病毒及其冷冻电镜结构解析
病毒学报,1000-8721,2016-09-15.杆状病毒-昆虫细胞系统表达的戊型肝炎病毒衣壳蛋白p495的纯化、结构解析以及免疫原性分析
病毒学报,1000-8721,2016-05-15.抗HPV11病毒样颗粒单克隆抗体的性质鉴定及初步应用
中国生化药物杂志,1005-1678,2016-04-28.基于假病毒的人乳头瘤病毒小鼠感染模型的建立及HPV16VLP疫苗保护性评价
中国生化药物杂志,1005-1678,2015-11-28.我国戊型肝炎疫苗和诊断试剂原始创新研究
病毒学报,1000-8721,2015-05-29.中性粒细胞明胶酶相关脂质运载蛋白的单克隆抗体制备及化学发光免疫定量检测试剂研究
中国生化药物杂志,1005-1678,2015-04-28.大肠杆菌表达的病毒样颗粒疫苗
生命的化学,1000-1336,2014-02-15.重组人乳头瘤病毒疫苗免疫原性检测方法的比较
中国生物制品学杂志,1004-5503,2013-07-20.抗H5亚型禽流感病毒单链抗体在毕赤酵母中的分泌型表达和生物活性分析
病毒学报,1000-8721,2011.戊型病毒性肝炎研究进展
厦门大学学报(自然科学版),0438-0479,2011.HIV-1 gp160截短蛋白在酿酒酵母中的表达
生命科学研究,1007-7847,2011.毕赤酵母分泌表达嵌合HEV表位的HBcAg颗粒
厦门大学学报(自然科学版) ,0438-0479,2009.重组毕赤酵母高密度发酵表达H5N1禽流感病毒糖蛋白
生物工程学报 ,1000-3061 ,2009.人乳头瘤病毒16型病毒样颗粒的制备及其免疫原性研究
病毒学报 ,1000-8721 ,2009.人乳头瘤病毒18型病毒样颗粒在大肠杆菌中的表达及免疫原性分析
生物工程学报 ,1000-3061 ,2009.大肠杆菌来源的人乳头瘤病毒11型病毒样颗粒的制备及其免疫原性
微生物学报 ,0001-6209 ,2009.梅毒螺旋体47 ku抗原的分段表达及抗原表位分析
厦门大学学报(自然科学版),0438-0479,2008-11-15.可捕获HBV的preS1单克隆抗体的制备及性质初探
厦门大学学报(自然科学版),0438-0479,2008-03-15.分子对接预测H5亚型禽流感病毒的广谱中和表位
科学通报,0023-074X,2008-01-30.戊型肝炎病毒基因1型和基因4型中和表位区域分子差异研究
病毒学报,1000-8721,2007-11-15.戊肝病毒Th表位肽免疫可增强其载体蛋白的体液免疫应答
生物工程学报,1000-3061,2007-03-30.人乳头瘤病毒16型假病毒中和实验的建立和初步应用
生物工程学报,1000-3061,2006-11-30.戊型肝炎病毒颗粒性蛋白疫苗H-2~d限制性Th表位的筛选
病毒学报,1000-8721,2006-05-30.基因Ⅰ、Ⅳ型戊型肝炎病毒高灵敏度通用引物的设计和初步应用
病毒学报,1000-8721,2005-05-20.SARS冠状病毒核衣壳(N)蛋白不同区域的原核表达
病毒学报,1000-8721,2005-03-20.蝾螺(Turbo cornutus Solander)N-乙酰-β-D-氨基葡萄糖苷酶的分离纯化及性质的初步研究
厦门大学学报(自然科学版),0438-0479,2004-09-30.二种多管水母光蛋白基因的分离、表达及生物活性初步研究
海洋学报(中文版),0253-4193,2004-07-13.重组戊型肝炎病毒衣壳蛋白工程菌的高密度培养
生物工程学报,1000-3061,2004-05-23.大肠杆菌重组颗粒性戊型肝炎疫苗对恒河猴的免疫保护
病毒学报,1000-8721,2004-03-30.戊型肝炎病毒衣壳蛋白同源二聚体的相互作用结构域
生物工程学报,1000-3061,2004-01-23.应用噬菌体随机肽库技术筛选戊型肝炎病毒中和表位模拟肽
生物工程学报,1000-3061,2003-11-23.戊型肝炎病毒中和性单克隆抗体的鉴定
病毒学报,1000-8721,2003-09-30.一种高效、稳定的分泌型原核表达载体的构建及应用
厦门大学学报(自然科学版),0438-0479,2003-07-30.传染性非典型肺炎病毒核蛋白的表达与活性检测
厦门大学学报(自然科学版),0438-0479,2003-07-30.乙型肝炎病毒表面抗原基因在墨西哥酸浆中的表达及其免疫原性的初步研究
病毒学报,1000-8721,2003-03-30.橙色荧光蛋白——绿色荧光蛋白GFPxm的改造
生物工程学报,1000-3061,2003-01-23.人乳头瘤病毒16型感染上皮细胞过程的研究进展
病毒学报,1000-8721,2025-01-03.基于大肠杆菌表达系统的人乳头瘤病毒疫苗研发进展
中国食品药品监管,1673-5390,2023-12-15.类病毒颗粒展示人免疫缺陷病毒V3抗原诱导小鼠产生跨型中和抗体
湖南师范大学学报(医学版),1673-016X,2022-08-25.疫苗技术的研究进展
国际生物制品学杂志,1673-4211,2022-02-10.分子对接预测病毒表位的研究进展
中国病毒病杂志,2095-0136,2019-07-20.疫苗市场概况和发展趋势
中国医药,1673-4777,2019-05-16.硫酸乙酰肝素蛋白聚糖在人乳头瘤病毒感染中的作用
中国病毒病杂志,2095-0136,2018-5-28.高危型人乳头瘤病毒诱导的抗体水平与宫颈病变的相关性
中国妇幼保健,1001-4411,2017.霍乱毒素B亚基展示HIV-1 gp41 MPER表位的研究
中国生化药物杂志,1005-1678,2017.人免疫缺陷病毒包膜蛋白V3多肽与白喉毒素无毒突变体CRM197结构域A融合蛋白的免疫原性分析及单克隆抗体筛选
中国生化药物杂志,1005-1678,2017.转录组测序技术研究进展
中国生化药物杂志,1005-1678,2017.人乳头瘤病毒衣壳蛋白C末端结构臂具有免疫原性并参与病毒—宿主细胞的相互作用
科学新闻,1671-6582,2017.人乳头瘤病毒预防性疫苗的研究进展和应用现状
中国生化药物杂志,1005-1678,2016-06-28.人乳头瘤病毒衣壳蛋白结构生物学研究进展
中国生化药物杂志,1005-1678,2016-05-28.疫苗产业概况及疫苗技术新进展
生物产业技术,1674-0319,2010-11-15.戊型肝炎诊断中血清学及核酸检测意义的研究
中华肝脏病杂志,1007-3418,2004-01-25.一种高效、稳定的分泌型原核表达载体的构建及应用
生物技术通讯,1009-0002,2003-12-30.抗HPV L2蛋白的广谱中和单克隆抗体或其抗原结合片段及它们的用途
CN103483446B,2016-04-06.抗HPV L1蛋白的广谱单克隆抗体或其抗原结合片段及它们的用途
CN103483447B,2015-11-25.用于预防、诊断及治疗戊型肝炎病毒的多肽, 及它们作为诊断试剂和疫苗
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