已发表成果:
WOK 论文 24 篇;专利发明 4 个;
Ginseng-derived panaxadiol ameliorates STZ-induced type 1 diabetes through inhibiting ROR gamma/IL-17A axis
Thyroid hormone resistance: Mechanisms and therapeutic development
DEPP Deficiency Contributes to Browning of White Adipose Tissue
FXR: structures, biology, and drug development for NASH and fibrosis diseases
Structural Basis for PPARs Activation by The Dual PPAR alpha/gamma Agonist Sanguinarine: A Unique Mode of Ligand Recognition
The interactions of small proline-rich proteins with late cornified envelope proteins are involved in the pathogenesis of psoriasis
The Interactions of Small Proline-Rich Proteins with Late Cornified Envelope Proteins are Involved in the Pathogenesis of Psoriasis
Identification of an allosteric hotspot for additive activation of PPAR gamma in antidiabetic effects
Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor beta
PPAR gamma Transcription Deficiency Exacerbates High-Fat Diet-Induced Adipocyte Hypertrophy and Insulin Resistance in Mice
Repositioning an Immunomodulatory Drug Vidofludimus as a Farnesoid X Receptor Modulator With Therapeutic Effects on NAFLD
Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs
Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR
Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity
Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin 1
A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease
Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
Targeting Nuclear Receptors with Marine Natural Products
Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes
The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism
Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells
Revealing a steroid receptor ligand as a unique PPAR gamma agonist
Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor alpha/delta Agonist