已发表成果:
WOK 论文 46 篇;专利发明 2 个;
Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation
Corneal stromal filler injection of gelatin-based photocurable hydrogels for maintaining the corneal thickness and reconstruction of corneal stroma
Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrate
Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction
Effective Corneal Neovascularization Therapy with Ros-Responsive Polydopamine Silica Nanoparticles Loaded with Fenofibrate
Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation
Isobaric Stable Isotope N-Phosphorylation Labeling (iSIPL) for Ultrasensitive Proteome Quantification
Isobaric Stable Isotope N-Phosphorylation Labeling (iSIPL) for Ultrasensitive Proteome Quantification
The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9
Decellularized squid mantle scaffolds as tissue-engineered corneal stroma for promoting corneal regeneration
Receptor-binding domain-anchored peptides block binding of severe acute respiratory syndrome coronavirus 2 spike proteins with cell surface angiotensin-converting enzyme 2
Phenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting
Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage
Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP
A natural product targets BRD4 to inhibit phase separation and gene transcription
Phenotypic and transcriptomic changes in the corneal epithelium following exposure to cigarette smoke
Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure
Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses
Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo
Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent
Resveratrol Promotes HIV-1 Tat Accumulation via AKT/FOXO1 Signal-ing Axis and Potentiates Vorinostat to Antagonize HIV-1 Latency
Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors
ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation
Synthesis and biological evaluations of N '-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents
POLYPHENOLS FROM Polygonum cuspidatum REACTIVATE LATENT HIV
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription
JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes
Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery
The role of autophagy in the pathogenesis of exposure keratitis
A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis
Epithelial dysplasia in pterygium postoperative granuloma
Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1
A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter
Stable isotope N-phosphoryl amino acids labeling for quantitative profiling of amine-containing metabolites using liquid chromatography mass spectrometry
Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells
Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents
A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP
Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription
Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism
Mechanism and factors that control HIV-1 transcription and latency activation
Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue
AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation
Viral-host interactions that control HIV-1 transcriptional elongation
Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell
Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression