Advances in gas pressure-based portable biosensing

Artificial intelligence in cell annotation for high-resolution RNA sequencing data

SERS Platform for Integrated Enrichment, Isolation, and Identification of Multiple Respiratory Viruses in a Single Assay Using 3D Stereoscopic SERS Tags and Flocked Swabs

DMF-DM-seq: Digital-Microfluidics Enabled Dual-Modality Sequencing of Single-Cell mRNA and microRNA with High Integration, Sensitivity, and Automation

Au-Pt Coating Improved Catalytic Stability of Au@AuPt Nanoparticles for Pressure-Based Point-of-Care Detection of <i>Escherichia coli</i> O157:H7

Identification of new AAV vectors with enhanced blood-brain barrier penetration efficiency <i>via</i> organ-on-a-chip

Aptamer-RIBOTAC Strategy Enabling Tumor-Specific Targeted Degradation of MicroRNA for Precise Cancer Therapy

Advanced sequencing-based high-throughput and long-read single-cell transcriptome analysis

In Situ Detection of Nucleic Acids in Extracellular Vesicles via Membrane Fusion

Highly Multiplexing, Throughput and Efficient Single-Cell Protein Analysis with Digital Microfluidics

Well-Paired-Seq2: High-Throughput and High-Sensitivity Strategy for Characterizing Low RNA-Content Cell/Nucleus Transcriptomes

Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS-STING Signaling

Domain generalization enables general cancer cell annotation in single-cell and spatial transcriptomics

Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics

Assessing the Practical Application of Imaging Mass Cytometry for Visualizing Tumor Immune Microenvironment Heterogeneity

Decoding Biomechanical Cues Based on DNA Sensors

Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing

DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

Deciphering molecular response of cell-cell interactions at the single-cell level by precise on-demand cell assembly

Metabolic Labeling and Digital Microfluidic Single-Cell Sequencing for Single Bacterial Genotypic-Phenotypic Analysis

Fingerprint Profiling of Glycans on Extracellular Vesicles via Lectin-Induced Aggregation Strategy for Precise Cancer Diagnostics

Capturing nascent extracellular vesicles by metabolic glycan labeling-assisted microfluidics

mitoSplitter: A mitochondrial variants- based method for efficient demultiplexing of pooled single- cell RNA- seq

Biotemplated precise assembly approach toward ultra-scaled high-performance electronics

Aptamer-based Isolation and Analysis Methods for Extracellular Vesicles

Automated and label-free detection of HIV DNA via digital microfluidics-chemiluminescence analysis

Chromogenic Visualization of Single RNA Molecules <i>In Situ</i> with Duplex Capability by Rolling Circle Amplification with Alkaline Phosphatase

Diverse SARS-CoV-2 aptamers overcome variant antigenic shift

Multifunctional Nanoprobe-Amplified Enzyme-Linked Immunosorbent Assay on Capillary: A Universal Platform for Simple, Rapid, and Ultrasensitive Dual-Mode Pathogen Detection

Simultaneous quantification of exosomal MMP14 expression and proteolysis activity on a spherical dual-probe-based fluorescent nanosensor

Isolation of PD-L1 Extracellular Vesicle Subpopulations Using DNA Computation Mediated Microfluidic Tandem Separation

Encoded Fusion-Mediated MicroRNA Signature Profiling of Tumor-Derived Extracellular Vesicles for Pancreatic Cancer Diagnosis

Sensitive and automated detection of bacteria by CRISPR/Cas12a-assisted amplification with digital microfluidics

Integrated single-tube operation for rapid and uniform single-cell whole-genome sequencing

Molecular Crowding Modulates SARS-CoV-2 Aptamer Affinity

Detection of circulating tumor cells using antibody-functionalized microchips to monitor tumorigenesis in a mouse model of metastatic breast cancer

Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics

Logic-Gates of Gas Pressure for Portable, Intelligent and Multiple Analysis of Metal Ions

Periostin deficiency reduces PD-1+tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer

Automated study on kinetics and biosensing of glow-type luminescence reaction via digital microfluidics-chemiluminescence

mu-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway: a comprehensive study including randomized controlled trial

Acid-accelerated hydrolysis of NaBH4: a gas-generation reaction for diverse gas pressure biosensing

Microfluidic chip with reversible interface for noninvasive remission status monitoring and prognosis prediction of acute myeloid leukemia

Metabolic fluorine labeling and hotspot imaging of dynamic gut microbiota in mice

Digital microfluidics for biological analysis and applications

Deconvolution algorithms for inference of the cell-type composition of the spatial transcriptome

Microfluidics-based single cell analysis: from transcriptomics to spatiotemporal multi-omics

Recent progress in microfluidic biosensors with different driving forces

Recent advances in exosomal RNAs analysis towards diagnostic and therapeutic applications

ARMOR: Auto-Assembled Resilient Biomimetic Calcified Ornaments for Selective Cell Protection by Dual-Aptamer-Driven Hybridization Chain Reaction

Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins

Dual-Mode Logic Gate for Intelligent and Portable Detection of MicroRNA Based on Gas Pressure and Lateral Flow Assay

A Fluid Multivalent Magnetic Interface for High-Performance Isolation and Proteomic Profiling of Tumor-Derived Extracellular Vesicles

De Novo Evolution of an Antibody-Mimicking Multivalent Aptamer via a DNA Framework

Reliable Detection of Extracellular PD-L1 by DNA Computation-Mediated Microfluidics

Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding

Digital-scRRBS: A Cost-Effective, Highly Sensitive, and Automated Single-Cell Methylome Analysis Platform via Digital Microfluidics

Recent progress in co-detection of single-cell transcripts and proteins

Highly Multiplexed, Efficient, and Automated Single-Cell MicroRNA Sequencing with Digital Microfluidics.

Microfluidic Enrichment of Intact SARS-CoV-2 Viral Particles by Stoichiometric Balanced DNA Computation

Aptamer-Assisted Blockade of the Immune Suppressor Sialic Acid-Binding Immunoglobulin-Like Lectin-15 for Cancer Immunotherapy

Beyond single cells: microfluidics empowering multiomics analysis

Hierarchical Fluid Interface Enables Spatiotemporal Regulation of Ligand Distribution to Increase Kinetics and Thermodynamics of Interfacial Binding Reaction

Visualizing germination of microbiota endospores in the mammalian gut

Rapid Point-of-Care Assay by SERS Detection of SARS-CoV-2 Virus and Its Variants

Deep transfer learning enables lesion tracing of circulating tumor cells

Bio-orthogonal Metabolic Fluorine Labeling Enables Deep-Tissue Visualization of Tumor Cells In Vivo by F-19 Magnetic Resonance Imaging

Enhanced molecular recognition on microfluidic affinity interfaces

Computational tools for aptamer identification and optimization

Elucidating the Effect of Nanoscale Receptor-Binding Domain Organization on SARS-CoV-2 Infection and Immunity Activation with DNA Origami

Fluid nanoporous microinterface enables multiscale-enhanced affinity interaction for tumor-derived extracellular vesicle detection

Thermodynamic and Kinetic Modulation of Microfluidic Interfaces by DNA Nanoassembly Mediated Merit-Complementary Heteromultivalency

Synergetic collision and space separation in microfluidic chip for efficient affinity-discriminated molecular selection

Novel electroactive ferrocene-based covalent organic frameworks towards electrochemical label-free aptasensors for the detection of Cardiac Troponin I

Simultaneous single-cell genome and transcriptome sequencing in nanoliter droplet with digital microfluidics identifying essential driving genes

A general strategy for detection of tumor-derived extracellular vesicle microRNAs using aptamer-mediated vesicle fusion

Integrated microfluidic devices for in vitro diagnostics at point of care

Mechanosensing view of SARS-CoV-2 infection by a DNA nano-assembly

Spatial- and Valence-Matched Neutralizing DNA Nanostructure Blocks Wild-Type SARS- CoV-2 and Omicron Variant Infection

LY6E protein facilitates adeno-associated virus crossing in a biomimetic chip model of the human blood-brain barrier

Quantification-Promoted Discovery of Glycosylated Exosomal PD-L1 as a Potential Tumor Biomarker

Decoding Expression Dynamics of Protein and Transcriptome at the Single-Cell Level in Paired Picoliter Chambers

Spherical neutralizing aptamer suppresses SARS-CoV-2 Omicron escape

Quantification of Intracellular Proteins in Single Cells Based on Engineered Picoliter Droplets

Spatially Patterned Neutralizing Icosahedral DNA Nanocage for Efficient SARS-CoV-2 Blocking

Suppressing high-dimensional crystallographic defects for ultra-scaled DNA arrays

Amplified visualization and function exploration of exosomal protein-specific glycosylation using hybridization chain reaction from non-functional epitope

Antibody-engineered red blood cell interface for high-performance capture and release of circulating tumor cells

Well-Paired-Seq: A Size-Exclusion and Locally Quasi-Static Hydrodynamic Microwell Chip for Single-Cell RNA-Seq

Novel Electroactive Ferrocene-Based Covalent Organic Frameworks Towards Electrochemical Label-Free Aptasensors for the Detection of Cardiac Troponin I

A General Strategy for Detection of Tumor-Derived Exosomal Micrornas Using Aptamer-Mediated Vesicle Fusion

Simultaneous Single-Cell Genome and Transcriptome Sequencing in Nanoliter Droplet with Digital Microfluidics Identifying Essential Driving Genes

Cilo-seq: highly sensitive cell-in-library-out single-cell transcriptome sequencing with digital microfluidics

Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy

A polypyrrole-mediated photothermal biosensor with a temperature and pressure dual readout for the detection of protein biomarkers

LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis

Structure- and Interaction-Based Design of Anti-SARS-CoV-2 Aptamers

Selective, user-friendly, highly porous, efficient, and rapid (SUPER) filter for isolation and analysis of rare tumor cells

Single-Cell Digital Microfluidic Mass Spectrometry Platform for Efficient and Multiplex Genotyping of Circulating Tumor Cells

An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system

Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy

Magnetofluid-Integrated Multicolor Immunochip for Visual Analysis of Neutralizing Antibodies to SARS-CoV-2 Variants

Portable and Label-Free Sensor Array for Discriminating Multiple Analytes via a Handheld Gas Pressure Meter

Microfluidic single-cell multiomics analysis

Dissolution-Enhanced Luminescence Enhanced Digital Microfluidics Immunoassay for Sensitive and Automated Detection of H5N1

Neutralizing Aptamer-Lipid Nanoparticles for Synergistic Treatment of SARSCoV-2 Infection

Advantage-Complementary-Heteromultivalency Engineering can Facilitate Targeted Cell Capturing on Microfluidic Affinity Chips

HIGHLY PARALLEL, RAPID, AND SENSITIVE SINGLE-CELL PROTEIN ANALYSIS WITH DIGITAL MICROFLUIDICS

METABOLIC GLYCAN LABELING-BASED ISOLATION OF NEWLY SYNTHESIZED EXOSOMES IN IMMUNOTHERAPY

MICROFLUIDIC CELL ASSEMBLY DEVICE FOR CELL-CELL INTERACTION AT THE SINGLE-CELL LEVEL

TARGETED SYNTHESIS OF BIOMIMETIC CELL WALL FOR CIRCULATING TUMOR CELL IDENTIFICATION AND PROTECTION

Well-paired-seq: a Size-exclusion and Locally Quasi-static Hydrodynamic Microwell Chip for Single-cell RNA-seq

Rapid-Seq: Single-Cell Genome Sequencing by Directed Tn5 Tagmentation

FlUID MULTIVALENT MAGNETIC INTERFACE FOR HIGH-PERFORMANCE ISOLATION AND PROTEOMIC PROFILITING OF TUMOR-DERIVED EXTRACELLULAR VESICLES

Whole-Genome Profiling of Single Bacterial Cell by Digital Microfluidics-based Isolation and Sequencing

ENHANCED AND TUNABLE CELL ADHESION ON 3D-PATTERNED HIERARCHICAL NANOINTERFACE TO TRACK THE PHENOTYPIC DYNAMICS OF CIRCULATING TUMOR CELLS

MICROFLUIDIC CHIP-BASED NONINVASIVE REMISSION STATUS MONITORING AND PROGNOSIS PREDICTION OF ACUTE MYELOID LEUKEMIA

DYNAMIC MAGNETIC NANOMIXERS ENABLING RAPID ISOLATION AND MOLECULAR PROFILING OF TUMOR-DERIVED EXTRACELLULAR VESICLES

Y Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape

SARS-CoV-2-Encoded MiRNAs Inhibit Host Type I Interferon Pathway and Mediate Allelic Differential Expression of Susceptible Gene

Interfacing droplet microfluidics with antibody barcodes for multiplexed single-cell protein secretion profiling

d-Amino Acid-Based Metabolic Labeling Enables a Fast Antibiotic Susceptibility Test of Both Isolated Bacteria and Bronchoalveolar Lavage Fluid

Multi-Omics Comparison of the Spontaneous Diabetes Mellitus and Diet-Induced Prediabetic Macaque Models

Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics

HCV poly U/UC sequence-induced inflammation leads to metabolic disorders in vulvar lichen sclerosis

An electrochemical method for a rapid and sensitive immunoassay on digital microfluidics with integrated indium tin oxide electrodes coated on a PET film

Auto-Panning: a highly integrated and automated biopanning platform for peptide screening

Biodistributions of L,D-Transpeptidases in Gut Microbiota Revealed by In Vivo Labeling with Peptidoglycan Analogs

Microfluidic devices with simplified signal readout

Selection and applications of functional nucleic acids for infectious disease detection and prevention

Visualizing the Growth and Division of Rat Gut Bacteria by D-Amino Acid-Based in vivo Labeling and FISH Staining

A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection

Imaging Commensal Microbiota and Pathogenic Bacteria in the Gut

Highly paralleled emulsion droplets for efficient isolation, amplification, and screening of cancer biomarker binding phages

XMU-100 Anniversary Special Issue

Activation of Aptamers with Gain of Function by Small-Molecule-Clipping of Intramolecular Motifs

Entropy subspace separation-based clustering for noise reduction (ENCORE) of scRNA-seq data

Three-Dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut

Nucleic Acids Analysis

Imaging the in vivo growth patterns of bacteria in human gut Microbiota

Recent Advances in Aptamer-Based Liquid Biopsy

Digital Microfluidic Thermal Control Chip-Based Multichannel Immunosensor for Noninvasively Detecting Acute Myocardial Infarction

In Situ Visualization of PD-L1-Specific Glycosylation on Tissue Sections

Reversible Immunoaffinity Interface Enables Dynamic Manipulation of Trapping Force for Accumulated Capture and Efficient Release of Circulating Rare Cells

A Fully Automated and Integrated Microfluidic System for Efficient CTC Detection and Its Application in Hepatocellular Carcinoma Screening and Prognosis

LINT-Web: A Web-Based Lipidomic Data Mining Tool Using Intra-Omic Integrative Correlation Strategy

Mapping Gene Expression in the Spatial Dimension

HUNTER-Chip: Bioinspired Hierarchically Aptamer Structure-Based Circulating Fetal Cell Isolation for Non-Invasive Prenatal Testing

Analytical chemistry for infectious disease detection and prevention

In situ Raman enhancement strategy for highly sensitive and quantitative lateral flow assay

Coupling Aptamer-based Protein Tagging with Metabolic Glycan Labeling for In Situ Visualization and Biological Function Study of Exosomal Protein-Specific Glycosylation

Single-Cell Sequencing Methodologies: From Transcriptome to Multi-Dimensional Measurement

Multichannel Paper Chip-Based Gas Pressure Bioassay for Simultaneous Detection of Multiple MicroRNAs

Stimulus-Responsive Microfluidic Interface Enables Efficient Enrichment and Cytogenetic Profiling of Circulating Myeloma Cells

Microfluidic-Based Exosome Analysis for Liquid Biopsy

Dispen-Seq: a single-microparticle dispenser based strategy towards flexible cell barcoding for single-cell RNA sequencing

Aptamer-Based Detection of Circulating Targets for Precision Medicine

Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection

Sensitive, Rapid, and Automated Detection of DNA Methylation Based on Digital Microfluidics

Digital-WGS: Automated, highly efficient whole-genome sequencing of single cells by digital microfluidics

3D-printed integrative probeheads for magnetic resonance

Distance-based paper/PMMA integrated ELISA-chip for quantitative detection of immunoglobulin G

Microfluidic-Integrated Multicolor Immunosensor for Visual Detection of HIV-1 p24 Antigen with the Naked Eye

Revealing the in vivo growth and division patterns of mouse gut bacteria

DNA Nanolithography Enables a Highly Ordered Recognition Interface in a Microfluidic Chip for the Efficient Capture and Release of Circulating Tumor Cells

Polymerized cholesteric liquid crystal microdisks generated by centrifugal microfluidics towards tunable laser emissions [Invited]

Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein

Stimuli-Responsive Microfluidic Interface Enables Highly Efficient Capture and Release of Circulating Fetal Cells for Non-Invasive Prenatal Testing

A Highly Sensitive, Accurate, and Automated Single-Cell RNA Sequencing Platform with Digital Microfluidics

DNA-directed nanofabrication of high-performance carbon nanotube field-effect transistors

Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method

Highly parallel and efficient single cell mRNA sequencing with paired picoliter chambers

Selection of Aptamers Against Vimentin for Isolation and Release of Circulating Tumor Cells Undergoing Epithelial Mesenchymal Transition

Effects of Molecular Crowding on G-Quadruplex-hemin Mediated Peroxidase Activity

Retrograde en bloc resection for non-muscle invasive bladder tumor can reduce the risk of seeding cancer cells into the peripheral circulation

Trends in miniaturized biosensors for point-of-care testing

Droplet microfluidics for circulating tumor cell analysis

A Sequential Multidimensional Analysis Algorithm for Aptamer Identification based on Structure Analysis and Machine Learning

Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction

Aptamer-Based Liquid Biopsy

Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota

Crosstalk-free colloidosomes for high throughput single-molecule protein analysis

Quantification of Bacterial Metabolic Activities in the Gut by d-Amino Acid-Based In Vivo Labeling

Nucleic Acids: Chemistry, Nanotechnology, and Bioapplications Forum in Honor of Professor Weihong Tan on His 60th Birthday

Highly Sensitive Minimal Residual Disease Detection by Biomimetic Multivalent Aptamer Nanoclimber Functionalized Microfluidic Chip

Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability

Aptamer Generated by Cell-SELEX for Specific Targeting of Human Glioma Cells

Efficient Isolation and Phenotypic Profiling of Circulating Hepatocellular Carcinoma Cells via a Combinatorial-Antibody-Functionalized Microfluidic Synergetic-Chip

Tracing Tumor-Derived Exosomal PD-L1 by Dual-Aptamer Activated Proximity-Induced Droplet Digital PCR

Quantification of Bacterial Metabolic Activities in the Gut by d-Amino Acid-Based In Vivo Labeling

Building high-performance electronics from structural DNA Nanotechnology

Molecular science vs. molecular medicine

Exosomal PD-L1: an effective liquid biopsy target to predict immunotherapy response

Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs

Microfluidic generation of cholesteric liquid crystal droplets with an integrative cavity for dual-gain and controllable lasing

Catalase-linked immunosorbent pressure assay for portable quantitative analysis

Evolution of Nucleic Acid Aptamers Capable of Specifically Targeting Glioma Stem Cells via Cell-SELEX

Single cell transcriptomics: moving towards multi-omics

SuperCT: a supervised-learning framework for enhanced characterization of single-cell transcriptomic profiles

Stable Colloidosomes Formed by Self-Assembly of Colloidal Surfactant for Highly Robust Digital PCR

Beyond Capture: Circulating Tumor Cell Release and Single-Cell Analysis

Assessing the viability of transplanted gut microbiota by sequential tagging with D-amino acid-based metabolic probes

Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection

Bioinspired Engineering of a Multivalent Aptamer-Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells

Rapid, real-time chemiluminescent detection of DNA mutation based on digital microfluidics and pyrosequencing

Staining Traditional Colloidal Gold Test Strips with Pt Nanoshell Enables Quantitative Point-of-Care Testing with Simple and Portable Pressure Meter Readout

Visual Quantitative Detection of Circulating Tumor Cells with Single-Cell Sensitivity Using a Portable Microfluidic Device

Isolation of circulating fetal trophoblast using fetal-chip for non-invasive prenatal diagnosis

Biomimetic membrane enabled multivalent microfluidic chip for highly efficient enrichment of circulating tumor cells

Aptamer-based microfluidics for isolation, release and analysis of circulating tumor cells

Molecular Crowding Evolution for Enabling Discovery of Enthalpy-Driven Aptamers for Robust Biomedical Applications

Microfluidic Single-Cell Omics Analysis

Bacterial Extracellular Electron Transfer Occurs in Mammalian Gut

The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation

Centrifugal-Driven Droplet Generation Method with Minimal Waste for Single-Cell Whole Genome Amplification

PH-Triggered Silk Fibroin/Alginate Structures Fabricated in Aqueous Two-Phase System

Ultrasensitive and portable assay of mercury (II) ions via gas pressure as readout

An Allosteric-Probe for Detection of Alkaline Phosphatase Activity and Its Application in Immunoassay

Frequency-enhanced transferrin receptor antibody-labelled microfluidic chip (FETAL-Chip) enables efficient enrichment of circulating nucleated red blood cells for non-invasive prenatal diagnosis

Design and synthesis of ortho-phthalaldehyde phosphoramidite for single-step, rapid, efficient and chemoselective coupling of DNA with proteins under physiological conditions

Magnetic Microsphere with Surface Charge Switching-based Microfluidic Chip for DNA Extraction

Integrated paper-based microfluidic devices for point-of-care testing

A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami

Positive carbon dots with dual roles of nanoquencher and reference signal for the ratiometric fluorescence sensing of DNA

DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells

In Situ Pt Staining Method for Simple, Stable, and Sensitive Pressure-Based Bioassays

Ultrasensitive and Facile Detection of MicroRNA via a Portable Pressure Meter

Highly Sensitive and Automated Surface Enhanced Raman Scattering-based Immunoassay for H5N1 Detection with Digital Microfluidics

Target-responsive DNA hydrogel for nonenzymatic and visual detection of glucose

Gas-generating reactions for point-of-care testing

Lateral flow assay with pressure meter readout for rapid point-of-care detection of disease-associated protein

Microwell Array Method for Rapid Generation of Uniform Agarose Droplets and Beads for Single Molecule Analysis

A tridecaptin-based fluorescent probe for differential staining of Gram-negative bacteria

Portable detection of serum HER-2 in breast cancer by a pressure-based platform

Recent Progress in Microfluidics-Based Biosensing

Bioinspired engineering of multivalent aptamer-functionalized nanointerface to enhance capture and release of circulating tumor cells

An automated binding ligand affinity evaluation platform using digital microfluidics

Detection of T4 Polynucleotide Kinase via Allosteric Aptamer Probe Platform

Centrifugal micropipette-tip with pressure signal readout for portable quantitative detection of myoglobin

Selection and identification of transferrin receptor-specific peptides as recognition probes for cancer cells

A fully integrated distance readout ELISA-Chip for point-of-care testing with sample-in-answer-out capability

Integrated Distance-Based Origami Paper Analytical Device for One-Step Visualized Analysis

Isolation, Detection, and Antigen-Based Profiling of Circulating Tumor Cells Using a Size-Dictated Immunocapture Chip

Point-of-Care Assay of Telomerase Activity at Single-Cell Level via Gas Pressure Readout

Integrating Target-Responsive Hydrogel with Pressuremeter Readout Enables Simple, Sensitive, User-Friendly, Quantitative Point-of-Care Testing

A portable visual detection method based on a target-responsive DNA hydrogel and color change of gold nanorods

Competitive excitation and osmotic-pressure-mediated control of lasing modes in cholesteric liquid crystal microshells

Outstanding Reviewers for: Analyst in 2016

Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis

Enrichment and single-cell analysis of circulating tumor cells

miR-15a-3p and miR-16-1-3p Negatively Regulate Twist1 to Repress Gastric Cancer Cell Invasion and Metastasis

Design and synthesis of target-responsive hydrogel for portable visual quantitative detection of uranium with a microfluidic distance-based readout device

Target-responsive DNAzyme hydrogel for portable colorimetric detection of lanthanide(III) ions

Inhibition of the superantigenic activities of Staphylococcal enterotoxin A by an aptamer antagonist

Afi-chip: An equipment-free, low-cost, and universal binding ligand affinity evaluation platform

Surface-Enhanced Raman Scattering Active Plasmonic Nanoparticles with Ultrasmall Interior Nanogap for Multiplex Quantitative Detection and Cancer Cell Imaging

N-Myc-interacting protein (NMI) negatively regulates epithelial-mesenchymal transition by inhibiting the acetylation of NF-kappa B/p65

Evolution of DNA aptamers for malignant brain tumor gliosarcoma cell recognition and clinical tissue imaging

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy

Enzyme-Encapsulated Liposome-Linked Immunosorbent Assay Enabling Sensitive Personal Glucose Meter Readout for Portable Detection of Disease Biomarkers

Integration of target responsive hydrogel with cascaded enzymatic reactions and microfluidic paper-based analytic devices (μPADs) for point-of-care testing (POCT)

Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems

Detection of DNA methyltransferase activity using allosteric molecular beacons

Recent Progress in Aptamer-Based Functional Probes for Bioanalysis and Biomedicine

Microfluidic fabrication of cholesteric liquid crystal core-shell structures toward magnetically transportable microlasers

Distance-based microfluidic quantitative detection methods for point-of-care testing

Advance in phage display technology for bioanalysis

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

DNA-Mediated Morphological Control of Silver Nanoparticles

A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein

Using aptamers to elucidate esophageal cancer clinical samples

Molecular behavior of the aptamer HJ24 self-assembled on highly oriented pyrolytic graphite (HOPG)

Selection and Application of DNA Aptamer Against Oncogene Amplified in Breast Cancer 1

Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis

Simple and Rapid Functionalization of Gold Nanorods with Oligonucleotides Using an mPEG-SH/Tween 20-Assisted Approach

Evolution of DNA aptamers through in vitro metastatic-cell-based systematic evolution of ligands by exponential enrichment for metastatic cancer recognition and imaging

Label-free surface-enhanced Raman spectroscopy detection of DNA with single-base sensitivity

Target-responsive DNA hydrogel mediated stop-flow microfluidic paper-based analytic device for rapid, portable and visual detection of multiple targets

Design and synthesis of target-responsive aptamer-cross-linked hydrogel for visual quantitative detection of ochratoxin A

Using DNA aptamer probe for immunostaining of cancer frozen tissues

A label-free fluorescence strategy for sensitive detection of ATP based on the ligation-triggered super-sandwich

Target-responsive DNAzyme cross-linked hydrogel for visual quantitative detection of lead

A dual-signal amplification method for the DNA detection based on exonuclease III

Au@pt nanoparticle encapsulated target-responsive hydrogel with volumetric bar-chart chip readout for quantitative point-of-care testing

A cell-surface-anchored ratiometric fluorescent probe for extracellular pH sensing

Label-free fluorescence strategy for sensitive detection of adenosine triphosphate using a loop DNA probe with low background noise

Microfluidic approaches to rapid and efficient aptamer selection

In Vitro Selection of DNA Aptamers for Metastatic Breast Cancer Cell Recognition and Tissue Imaging

Monoclonal Surface Display SELEX for Simple, Rapid, Efficient, and Cost-Effective Aptamer Enrichment and Identification

Facile and Rapid Generation of Large-Scale Microcollagen Gel Array for Long-Term Single-Cell 3D Culture and Cell Proliferation Heterogeneity Analysis

In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier

Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice

Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgf beta 1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice

A novel signal-on DNAzyme-based electrochemiluminescence, sensor for Pb2+

Fluorescent molecular beacon nucleic acid probes for biomolecular recognition

A highly parallel microfluidic droplet method enabling single-molecule counting for digital enzyme detection

Loss of aldose reductase activates LKB1-AMPK and insulin signalling in liver cells and ameliorates Agouti signalling peptide-induced glucose intolerance, insulin resistance, inflammation, hepatosteatosis and obesity in mice

Carbon nanoparticle-protected aptamers for highly sensitive and selective detection of biomolecules based on nuclease-assisted target recycling signal amplification

A diazirine-based photoaffinity probe for facile and efficient aptamer-protein covalent conjugation

A T7 exonuclease-assisted cyclic enzymatic amplification method coupled with rolling circle amplification: a dual-amplification strategy for sensitive and selective microRNA detection

A multifunctional nanomicelle for real-time targeted imaging and precise near-infrared cancer therapy

ICP-MS-based multiplex and ultrasensitive assay of viruses with lanthanide-coded biospecific tagging and amplification strategies

Aldose Reductase Is Involved in the Development of Murine Diet-Induced Nonalcoholic Steatohepatitis

Graphene oxide protected nucleic acid probes for bioanalysis and biomedicine

Engineering of switchable aptamer micelle flares for molecular imaging in living cells

Induction of cyto-protective autophagy by paramontroseite VO2 nanocrystals

Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture

Preparation and characterizations of polyclonal antibodies against STAR protein QKI7b

An electrochemical sensor based on label-free functional allosteric molecular beacons for detection target DNA/miRNA

Target-responsive "sweet" hydrogel with glucometer readout for portable and quantitative detection of non-glucose targets

Stabilization of ssRNA on Graphene Oxide Surface: An Effective Way to Design Highly Robust RNA Probes

DNA aptamer-mediated cell targeting

Single-molecule photon-fueled DNA nanoscissors for DNA cleavage based on the regulation of substrate binding affinity by azobenzene

Backbone-modified molecular beacons for highly sensitive and selective detection of microRNAs based on duplex specific nuclease signal amplification

Cyclic enzymatic amplification method (CEAM) based on exonuclease III for highly sensitive bioanalysis

Application of Eletrodialysis to Enrich DNA Online in Microchip

miR-574-5p negatively regulates Qki6/7 to impact beta-catenin/Wnt signalling and the development of colorectal cancer

L -DNA molecular beacon: A safe, stable, and accurate intracellular nano-thermometer for temperature sensing in living cells

The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity

In vitro selection of highly efficient G-quadruplex-based DNAzymes

MicroRNA-297b-5p/3p target Mllt3/Af9 to suppress lymphoma cell proliferation, migration and invasion in vitro and tumor growth in nude mice

Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2

Single-molecule force spectroscopic studies on intra- and intermolecular interactions of G-quadruplex aptamer with target Shp2 protein

Facile synthesis of red-emitting lysozyme-stabilized Ag nanoclusters

Sonochemical synthesis of highly fluorescent glutathione-stabilized Ag nanoclusters and S2- sensing

Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples

Platinum nanoflowers supported on graphene oxide nanosheets: Their green synthesis, growth mechanism, and advanced electrocatalytic properties for methanol oxidation

Single-molecule emulsion PCR in microfluidic droplets

Massively parallel single-molecule and single-cell emulsion reverse transcription polymerase chain reaction using agarose droplet microfluidics

Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability

Highly parallel single-molecule amplification approach based on agarose droplet polymerase chain reaction for efficient and cost-effective aptamer selection

Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level

Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method

Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-alpha and Ameliorates Hepatosteatosis in Diabetic db/db Mice

Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme

Molecular aptamers for drug delivery

Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies

Aldo-Keto Reductase-7A Protects Liver Cells and Tissues From Acetaminophen-Induced Oxidative Stress and Hepatotoxicity

Linear molecular beacons for highly sensitive bioanalysis based on cyclic Exo III enzymatic amplification

Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal

Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins, and Small Molecules in Complex Biological Samples

Preparation of Reversible Colorimetric Temperature Nanosensors and Their Application in Quantitative Two-Dimensional Thermo-Imaging

Using population dynamics analysis by DGGE to design the bacterial consortium isolated from mangrove sediments for biodegradation of PAHs

A G-Quadruplex Aptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2 in vitro

Pyrene Excimer for DNA Sensors

A universal platform for sensitive and selective colorimetric DNA detection based on Exo III assisted signal amplification

Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity

Agarose droplet microfluidic approach for molecular evolution of aptamers

Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery

Caged molecular beacons: controlling nucleic acid hybridization with light

Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids

Chameleon clothes for quantitative oxygen imaging

DNAzyme crosslinked hydrogel: a new platform for visual detection of metal ions

A surface energy transfer nanoruler for measuring binding site distances on live cell surfaces

Synthesis of uniform-size hollow silica microspheres through interfacial polymerization in monodisperse water-in-oil droplets

Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells

Application of Aptamers in Biomedicine

A general excimer signaling approach for aptamer sensors

An aptamer cross-linked hydrogel as a colorimetric platform for visual detection

Application of Electrical Driven and Cationic Exchange Membrane to Capture and Enrich Deoxyribonucleic Acid

Agarose droplet microfluidics for highly parallel and efficient emulsion PCR

Agarose droplet microfluidics for highly parallel and efficient single molecule emulsion PCR

A cyclic enzymatic amplification method for sensitive and selective detection of nucleic acids

Pyrene excimer nucleic acid probes for biomolecule signaling

Dimerization of Hepatitis E Virus Capsid Protein E2s Domain Is Essential for Virus-Host Interaction

Intraperitoneal co-administration of thymosin alpha-1 ameliorates streptozotocin-induced pancreatic lesions and diabetes in C57BL/6 mice

Metabonomics studies of intact hepatic and renal cortical tissues from diabetic db/db mice using high-resolution magic-angle spinning 1H NMR spectroscopy

Molecular engineering of DNA: Molecular beacons

PMMA/PDMS valves and pumps for disposable microfluidics

miRNA-mediated osmoregulation in renal cells

Gene transfer: the challenge of regulated gene expression

Aldose reductase regulates hepatic peroxisome proliferator-activated receptor α phosphorylation and activity to impact lipid homeostasis

High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets

Prediction of a common neutralizing epitope of H5N1 avian influenza virus by in silico molecular docking

Pyrene excimer signaling molecular beacons for probing nucleic acids