Halogenated retinoid derivatives as dual RARα and RXRα modulators for treating acute promyelocytic leukemia cells

Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion

Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates

Nuclear receptor RXRa binds the precursor of miR-103 to inhibit its maturation

Dihydrotrichodimerol Purified from the Marine Fungus<i> Acremonium</i><i> citrinum</i> Prevents NAFLD by Targeting PPAR?

Non-Covalently Stapled H<SUP>+</SUP>/Cl<SUP>-</SUP> Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells

Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXR alpha-targeted anti-mitotic agents

USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and A beta generation

Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2

Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR gamma with potential anti-diabetic efficacy

Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway

Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER alpha to inhibit RANKL signaling

Centrosomal Localization of RXR alpha Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway

Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXR alpha through structure-based virtual screening

Design, synthesis and biological evaluation of tetrazole-containing RXR alpha ligands as anticancer agents

Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce beta-Amyloid Plaques in Alzheimer's Disease Mouse Model

3-Cl-AHPC inhibits pro-HGF maturation by inducing matriptase/HAI-1 complex formation

Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha

AlC(l)3 center dot 6H(2)O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol

Virtual screening and experimental validation identify novel modulators of nuclear receptor RXR alpha from Drugbank database

TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells

Recent Progress in the Design and Discovery of RXR Modulators Targeting Alternate Binding Sites of the Receptor

RXR alpha ligand Z-10 induces PML-RARa cleavage and APL cell apoptosis through disrupting PML-RARa/RXRa complex in a cAMP-independent manner

Binding characterization, synthesis and biological evaluation of RXR alpha antagonists targeting the coactivator binding site

Honokiol sensitizes breast cancer cells to TNF-alpha induction of apoptosis by inhibiting Nur77 expression

NSC-640358 acts as RXR alpha ligand to promote TNF alpha-mediated apoptosis of cancer cell

Nitrostyrene Derivatives Act as RXR alpha Ligands to Inhibit TNF alpha Activation of NF-kappa B

Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site

Double role of the hydroxy group of phosphoryl in palladium(II)-catalyzed ortho -olefination: A combined experimental and theoretical investigation

Experimental and theoretical studies on nickel-zinc-catalyzed cross-coupling of gem-dibromoalkenes with P(O)-H compounds

Targeting Truncated Retinoid X Receptor-alpha by CF31 Induces TNF-alpha-Dependent Apoptosis

A universal and multiplex kinase assay using gamma-[O-18(4)]-ATP

Nickel(II)-Magnesium-Catalyzed Cross-Coupling of 1,1-Dibromo-1-alkenes with Diphenylphosphine Oxide: One-Pot Synthesis of (E)-1-Alkenylphosphine Oxides or Bisphosphine Oxides

Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death

Regulation of proteolytic cleavage of retinoid X receptor-alpha by GSK-3 beta

Synthesis and SAR study of modulators inhibiting tRXR alpha-dependent AKT activation