已发表成果:
WOK 论文 41 篇;中文核心 3 篇;
Halogenated retinoid derivatives as dual RARα and RXRα modulators for treating acute promyelocytic leukemia cells
Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates
Nuclear receptor RXRa binds the precursor of miR-103 to inhibit its maturation
Dihydrotrichodimerol Purified from the Marine Fungus<i> Acremonium</i><i> citrinum</i> Prevents NAFLD by Targeting PPAR?
Non-Covalently Stapled H<SUP>+</SUP>/Cl<SUP>-</SUP> Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy
SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells
Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXR alpha-targeted anti-mitotic agents
USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and A beta generation
Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2
Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR gamma with potential anti-diabetic efficacy
Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway
Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER alpha to inhibit RANKL signaling
Centrosomal Localization of RXR alpha Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXR alpha through structure-based virtual screening
Design, synthesis and biological evaluation of tetrazole-containing RXR alpha ligands as anticancer agents
Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce beta-Amyloid Plaques in Alzheimer's Disease Mouse Model
3-Cl-AHPC inhibits pro-HGF maturation by inducing matriptase/HAI-1 complex formation
Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds
Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha
AlC(l)3 center dot 6H(2)O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol
Virtual screening and experimental validation identify novel modulators of nuclear receptor RXR alpha from Drugbank database
TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells
Recent Progress in the Design and Discovery of RXR Modulators Targeting Alternate Binding Sites of the Receptor
RXR alpha ligand Z-10 induces PML-RARa cleavage and APL cell apoptosis through disrupting PML-RARa/RXRa complex in a cAMP-independent manner
Binding characterization, synthesis and biological evaluation of RXR alpha antagonists targeting the coactivator binding site
Honokiol sensitizes breast cancer cells to TNF-alpha induction of apoptosis by inhibiting Nur77 expression
NSC-640358 acts as RXR alpha ligand to promote TNF alpha-mediated apoptosis of cancer cell
Nitrostyrene Derivatives Act as RXR alpha Ligands to Inhibit TNF alpha Activation of NF-kappa B
Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site
Double role of the hydroxy group of phosphoryl in palladium(II)-catalyzed ortho -olefination: A combined experimental and theoretical investigation
Experimental and theoretical studies on nickel-zinc-catalyzed cross-coupling of gem-dibromoalkenes with P(O)-H compounds
Targeting Truncated Retinoid X Receptor-alpha by CF31 Induces TNF-alpha-Dependent Apoptosis
A universal and multiplex kinase assay using gamma-[O-18(4)]-ATP
Nickel(II)-Magnesium-Catalyzed Cross-Coupling of 1,1-Dibromo-1-alkenes with Diphenylphosphine Oxide: One-Pot Synthesis of (E)-1-Alkenylphosphine Oxides or Bisphosphine Oxides
Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death
Regulation of proteolytic cleavage of retinoid X receptor-alpha by GSK-3 beta
Synthesis and SAR study of modulators inhibiting tRXR alpha-dependent AKT activation
基于分子对接技术靶向PPARγ的降糖药物虚拟筛选
中国医院药学杂志,1001-5213,2021-01-19.以寨卡病毒NS3解旋酶为靶点的海洋天然产物库的虚拟筛选与成药性评价
厦门大学学报(自然科学版),0438-0479,2019-08-22.以寨卡病毒NS3解旋酶为靶点的海洋天然产物库的虚拟筛选与成药性评价
厦门大学学报(自然科学版),0438-0479,2019-08-22.