WWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway

Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

A mitochondrial EglN1-AMPKa axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress

A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression

AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

Identification of serum metabolites enhancing inflammatory responses in COVID-19

Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function

Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

Glucose Starvation Blocks Translation at Multiple Levels

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Carbohydrates: Not All that Bad?

Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity

Structural and Dynamic Insights into the Mechanism of Allosteric Signal Transmission in ERK2-Mediated MKP3 Activation

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK