Halogenated retinoid derivatives as dual RARα and RXRα modulators for treating acute promyelocytic leukemia cells

Unveiling the Mechanisms of Apoptosis Induction by Deep-Sea-Derived Polyketide-Terpenoid Hybrids from <i>Penicillium allii-sativi</i>: A Focus on Mitochondrial and mTOR Pathways

ErbB3 is required for hyperaminoacidemia-induced pancreatic a cell hyperplasia

Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion

Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates

Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts

Nuclear receptor RXRa binds the precursor of miR-103 to inhibit its maturation

Dermal adipogenesis is regulated by an interplay between the WNT-β-catenin and IL1 signaling pathways during skin development and regeneration

Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma

Acid-Responsive Macroporous Silica Nanoparticles for Bcl-2-Functional-Converting Peptide Release and Synergism with Celastrol for Enhanced Therapy against Resistant Cancer

Disruption of the glucagon receptor increases glucagon expression beyond alpha-cell hyperplasia in zebrafish

Chemical Constituents of the Deep-Sea-Derived Penicillium citreonigrum MCCC 3A00169 and Their Antiproliferative Effects

SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells

Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXR alpha-targeted anti-mitotic agents

The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease

Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-alpha transcriptional effect

Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2

Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR gamma with potential anti-diabetic efficacy

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Impact of macroporous silica nanoparticles at sub-50nm on bio-behaviors and biosafety in drug-resistant cancer models

Penipyrols C-G and methyl-penipyrol A, alpha-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131

Malayoside, a cardenolide glycoside extracted from Antiaris toxicaria Lesch, induces apoptosis in human non-small lung cancer cells via MAPK-Nur77 signaling pathway

Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

Novel selective phosphodiesterase inhibitors promote the adipogenic function of dermal fibroblasts: Implication to treat hair loss

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway

Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER alpha to inhibit RANKL signaling

Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi

Centrosomal Localization of RXR alpha Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

Rosiglitazone binds to RXR alpha to induce RXR alpha tetramerization and NB4 cell differentiation

Diet-induced obesity impairs the antimicrobial defense function of dermal adipocyte progenitors

Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety

Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment

Macroporous organosilicon nanocomposites co-deliver Bcl2-converting peptide and chemotherapeutic agent for synergistic treatment against multidrug resistant cancer

The Roles of GSK-3 beta in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma

SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway

Sulindac-derived retinoid X receptor-alpha modulator attenuates atherosclerotic plaque progression and destabilization in ApoE(-/-) mice

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway

Oncogenic potential of truncated RXR alpha during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXR alpha through structure-based virtual screening

Design and synthesis of biotinylated cardiac glycosides for probing Nur77 protein inducting pathway

Steroids from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor (RXR)-alpha Pathway

Design, synthesis and biological evaluation of tetrazole-containing RXR alpha ligands as anticancer agents

Cancer therapeutics based on BCL-2 functional conversion

Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce beta-Amyloid Plaques in Alzheimer's Disease Mouse Model

3-Cl-AHPC inhibits pro-HGF maturation by inducing matriptase/HAI-1 complex formation

Dendrimer-like mesoporous silica nanospheres with suitable surface functionality to combat the multidrug resistance

Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds

Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells

Synthesis of C-3-Neoglycosides of digoxigenin and their anticancer activities

Berberine binds RXR alpha to suppress beta-catenin signaling in colon cancer cells

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38 alpha MAPK

PAMAM dendrimers-mediated specific targeting and intracellular apoptosis with aptamer and Bcl-2 converting peptide conjugation

Synthesis of MeON-neoglycosides of digoxigenin with 6-deoxy- and 2,6-dideoxy-D-glucose derivatives and their anticancer activity

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha

AlC(l)3 center dot 6H(2)O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma

Virtual screening and experimental validation identify novel modulators of nuclear receptor RXR alpha from Drugbank database

TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells

Recent Progress in the Design and Discovery of RXR Modulators Targeting Alternate Binding Sites of the Receptor

RXR alpha ligand Z-10 induces PML-RARa cleavage and APL cell apoptosis through disrupting PML-RARa/RXRa complex in a cAMP-independent manner

Binding characterization, synthesis and biological evaluation of RXR alpha antagonists targeting the coactivator binding site

NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis

Honokiol sensitizes breast cancer cells to TNF-alpha induction of apoptosis by inhibiting Nur77 expression

Targeting truncated RXR alpha for cancer therapy

NSC-640358 acts as RXR alpha ligand to promote TNF alpha-mediated apoptosis of cancer cell

Nitrostyrene Derivatives Act as RXR alpha Ligands to Inhibit TNF alpha Activation of NF-kappa B

Identification of a New RXR alpha Antagonist Targeting the Coregulator-Binding Site

Novel polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site

Total synthesis and RXR alpha-mediated transcription studies of neriifolone B and related compounds

Non-genomic responses of nuclear receptors to environmental signals

Targeting Truncated Retinoid X Receptor-alpha by CF31 Induces TNF-alpha-Dependent Apoptosis

Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria

Regulation of proteolytic cleavage of retinoid X receptor-alpha by GSK-3 beta

Synthesis and SAR study of modulators inhibiting tRXR alpha-dependent AKT activation

Antagonist Effect of Triptolide on AKT Activation by Truncated Retinoid X Receptor-alpha

Structural modification of ginsenoside Rh-2 by fatty acid esterification and its detoxification property in antitumor

Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2

Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXR alpha Transcriptional Regulation

Xanthone and Benzophenone Glycosides from the Stems of Cratoxylum formosum ssp pruniflorum

Bioactive Xanthones from the Stems of Cratoxylum formosum ssp pruniflorum

NSAID Sulindac and Its Analog Bind RXR alpha and Inhibit RXR alpha-Dependent AKT Signaling

Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid

A unique cytoplasmic localization of retinoic acid receptor-γ and its regulations

A short Nur77-derived peptide converts Bcl-2 from a protector to a killer

RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells