Targeting synaptic pathology in Alzheimer's disease

P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

Microglial Dysfunction in Autism Spectrum Disorder

Synaptic adhesion molecule protocadherin-γC5 mediates β-amyloid-induced neuronal hyperactivity and cognitive deficits in Alzheimer's disease

TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance

Tau reduction attenuates autism-like features in Fmr1 knockout mice

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling

Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer's disease

The Aging Biomarker Consortium represents a new era for aging research in China

Minocycline protects against microgliopathy in a <i>Csf1r</i> haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Biomarkers of aging

Heart-brain axis: Association of congenital heart abnormality and brain diseases

Targeting adverse effects of antiseizure medication on offspring: current evidence and new strategies for safety

Relationship between right-to-left shunt, hypoxia, and epilepsy

Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits

Development of a Gastrointestinal-Myoelectrical-Activity-Based Nomogram Model for Predicting the Risk of Mild Cognitive Impairment

SNX15 Regulates Cell Surface Recycling of APP and A beta Generation (vol 53, pg 3690, 2016)

Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder

APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders

A Novel CNTNAP2 Mutation Results in Abnormal Neuronal E/I Balance

Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication

Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival

Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy

Overexpression of Human SNX27 Enhances Learning and Memory Through Modulating Synaptic Plasticity in Mice

TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer's Disease

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities

Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to A beta(42)in triggering receptor expressed on myeloid cells 2 loss-of-function murine models

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities

A Self-Assembled alpha-Synuclein Nanoscavenger for Parkinson's Disease

Plasma levels of Interleukin 18 but not amyloid-beta or Tau are elevated in female depressive patients

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates A beta Accumulation and Memory Deficits in an AD Mouse

Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

Role of Rab GTPases in Alzheimer's Disease

Silencing MicroRNA-155 Attenuates Kainic Acid-Induced Seizure by Inhibiting Microglia Activation

TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism

Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy

Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease

Intracellular trafficking of TREM2 is regulated by presenilin 1

Synaptic Adhesion Molecule Pcdh-gamma C5 Mediates Synaptic Dysfunction in Alzheimer's Disease

The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death

Soluble TREM2 induces inflammatory responses and enhances microglial survival

TREM2 Promotes Microglial Survival by Activating Wnt/beta-Catenin Pathway

A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

Quercetin stabilizes apolipoprotein E and reduces brain A beta levels in amyloid model mice

Protective role of miR-23b-3p in kainic acid-induced seizure

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology

Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway

RPS23RG1 reduces A beta oligomer-induced synaptic and cognitive deficits

MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy

Demographic and Lifestyle Characteristics, but Not Apolipoprotein E Genotype, Are Associated with Intelligence among Young Chinese College Students

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Overexpression of SLC25A38 protein on acute lymphoblastic leukemia cells

M1 muscarinic acetylcholine receptor in Alzheimer's disease

Trafficking regulation of proteins in Alzheimer's disease

Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE

Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation

APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival

Transcriptional regulation and its misregulation in Alzheimer's disease

Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration

Alzheimer's beta-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of beta-Amyloid

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation

Salubrinal attenuates beta-amyloid-induced neuronal death and microglial activation by inhibition of the NF-kappa B pathway

CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)

Proteolytic processing of Alzheimer's ss-amyloid precursor protein

Differential regulation of BACE1 expression by oxidative and nitrosative signals

APP processing in Alzheimer's disease

The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation

Substrate check of gamma-secretase

A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's beta-Amyloid Levels and Tau Phosphorylation

Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid

Intracellular trafficking of presenilin 1 is regulated by β-amyloid precursor protein and phospholipase D1

Presenilins regulate the cellular level of the tumor suppressor PTEN

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

Hypoxia-inducible factor 1 (HIF-1)-mediated hypoxia increases BACE1 expression and β-amyloid generation

Molecular and cellular mechanisms for Alzheimer's disease: Understanding APP metabolism