CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion

Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts

Discovery of 5-(Pyrimidin-2-ylamino)-1<i>H</i>-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer

Nuclear receptor RXRa binds the precursor of miR-103 to inhibit its maturation

A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus <i>Pallidocercospora crystalline</i>

Human embryonic stem cell-derived neural crest model unveils CD55 as a cancer stem cell regulator for therapeutic targeting in MYCN-amplified neuroblastoma

Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2

Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR gamma with potential anti-diabetic efficacy

Efficacy of Water-Soluble Pearl Powder Components Extracted by a CO2 Supercritical Extraction System in Promoting Wound Healing

Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

A computational framework of host-based drug repositioning for broad-spectrum antivirals against RNA viruses

Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER alpha to inhibit RANKL signaling

Centrosomal Localization of RXR alpha Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

Rosiglitazone binds to RXR alpha to induce RXR alpha tetramerization and NB4 cell differentiation

Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii

Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety

The Roles of GSK-3 beta in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma

Low expression of miR-99b promotes progression of clear cell renal cell carcinoma by up-regulating IGF1R/Akt/mTOR signaling

Sulindac-derived retinoid X receptor-alpha modulator attenuates atherosclerotic plaque progression and destabilization in ApoE(-/-) mice

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway

Oncogenic potential of truncated RXR alpha during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce beta-Amyloid Plaques in Alzheimer's Disease Mouse Model

3-Cl-AHPC inhibits pro-HGF maturation by inducing matriptase/HAI-1 complex formation

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38 alpha MAPK

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha

AlC(l)3 center dot 6H(2)O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Virtual screening and experimental validation identify novel modulators of nuclear receptor RXR alpha from Drugbank database

RXR alpha ligand Z-10 induces PML-RARa cleavage and APL cell apoptosis through disrupting PML-RARa/RXRa complex in a cAMP-independent manner

Binding characterization, synthesis and biological evaluation of RXR alpha antagonists targeting the coactivator binding site

Honokiol sensitizes breast cancer cells to TNF-alpha induction of apoptosis by inhibiting Nur77 expression

Targeting truncated RXR alpha for cancer therapy

NSC-640358 acts as RXR alpha ligand to promote TNF alpha-mediated apoptosis of cancer cell

Nitrostyrene Derivatives Act as RXR alpha Ligands to Inhibit TNF alpha Activation of NF-kappa B

Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site

Targeting Truncated Retinoid X Receptor-alpha by CF31 Induces TNF-alpha-Dependent Apoptosis

Synthesis and SAR study of modulators inhibiting tRXR alpha-dependent AKT activation

Regulation of proteolytic cleavage of retinoid X receptor-alpha by GSK-3 beta

Significance of CD4 T-Cell Adenosine Triphosphate Levels Monitoring in Elderly Renal Transplant Recipients

Inhibition of beta-catenin signaling by nongenomic action of orphan nuclear receptor Nur77

Antagonist Effect of Triptolide on AKT Activation by Truncated Retinoid X Receptor-alpha

Assessing Immunologic Function Through CD4 T-lymphocyte Ahenosine Triphosphate Levels by ImmuKnow Assay in Chinese Patients Following Renal Transplantation

NSAID Sulindac and Its Analog Bind RXR alpha and Inhibit RXR alpha-Dependent AKT Signaling

A unique cytoplasmic localization of retinoic acid receptor-γ and its regulations