已发表成果:
WOK 论文 45 篇;专利发明 2 个;图书及章节 1 本;
CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β
Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts
Discovery of 5-(Pyrimidin-2-ylamino)-1<i>H</i>-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer
Nuclear receptor RXRa binds the precursor of miR-103 to inhibit its maturation
A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus <i>Pallidocercospora crystalline</i>
Human embryonic stem cell-derived neural crest model unveils CD55 as a cancer stem cell regulator for therapeutic targeting in MYCN-amplified neuroblastoma
Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2
Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR gamma with potential anti-diabetic efficacy
Efficacy of Water-Soluble Pearl Powder Components Extracted by a CO2 Supercritical Extraction System in Promoting Wound Healing
Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
A computational framework of host-based drug repositioning for broad-spectrum antivirals against RNA viruses
Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER alpha to inhibit RANKL signaling
Centrosomal Localization of RXR alpha Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
Rosiglitazone binds to RXR alpha to induce RXR alpha tetramerization and NB4 cell differentiation
Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii
Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety
The Roles of GSK-3 beta in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma
Low expression of miR-99b promotes progression of clear cell renal cell carcinoma by up-regulating IGF1R/Akt/mTOR signaling
Sulindac-derived retinoid X receptor-alpha modulator attenuates atherosclerotic plaque progression and destabilization in ApoE(-/-) mice
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Oncogenic potential of truncated RXR alpha during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce beta-Amyloid Plaques in Alzheimer's Disease Mouse Model
3-Cl-AHPC inhibits pro-HGF maturation by inducing matriptase/HAI-1 complex formation
Modulation of the Nur77-Bcl-2 apoptotic pathway by p38 alpha MAPK
Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha
AlC(l)3 center dot 6H(2)O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol
Virtual screening and experimental validation identify novel modulators of nuclear receptor RXR alpha from Drugbank database
RXR alpha ligand Z-10 induces PML-RARa cleavage and APL cell apoptosis through disrupting PML-RARa/RXRa complex in a cAMP-independent manner
Binding characterization, synthesis and biological evaluation of RXR alpha antagonists targeting the coactivator binding site
Honokiol sensitizes breast cancer cells to TNF-alpha induction of apoptosis by inhibiting Nur77 expression
Targeting truncated RXR alpha for cancer therapy
NSC-640358 acts as RXR alpha ligand to promote TNF alpha-mediated apoptosis of cancer cell
Nitrostyrene Derivatives Act as RXR alpha Ligands to Inhibit TNF alpha Activation of NF-kappa B
Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site
Targeting Truncated Retinoid X Receptor-alpha by CF31 Induces TNF-alpha-Dependent Apoptosis
Synthesis and SAR study of modulators inhibiting tRXR alpha-dependent AKT activation
Regulation of proteolytic cleavage of retinoid X receptor-alpha by GSK-3 beta
Significance of CD4 T-Cell Adenosine Triphosphate Levels Monitoring in Elderly Renal Transplant Recipients
Inhibition of beta-catenin signaling by nongenomic action of orphan nuclear receptor Nur77
Antagonist Effect of Triptolide on AKT Activation by Truncated Retinoid X Receptor-alpha
Assessing Immunologic Function Through CD4 T-lymphocyte Ahenosine Triphosphate Levels by ImmuKnow Assay in Chinese Patients Following Renal Transplantation
NSAID Sulindac and Its Analog Bind RXR alpha and Inhibit RXR alpha-Dependent AKT Signaling
A unique cytoplasmic localization of retinoic acid receptor-γ and its regulations
第八章 细胞内吞作用//.分子细胞生物学. (专著). 清华大学出版社, 2011年09月.