Aptamer-RIBOTAC Strategy Enabling Tumor-Specific Targeted Degradation of MicroRNA for Precise Cancer Therapy

Highly Multiplexing, Throughput and Efficient Single-Cell Protein Analysis with Digital Microfluidics

Well-Paired-Seq2: High-Throughput and High-Sensitivity Strategy for Characterizing Low RNA-Content Cell/Nucleus Transcriptomes

Deciphering molecular response of cell-cell interactions at the single-cell level by precise on-demand cell assembly

Metabolic Labeling and Digital Microfluidic Single-Cell Sequencing for Single Bacterial Genotypic-Phenotypic Analysis

Fingerprint Profiling of Glycans on Extracellular Vesicles via Lectin-Induced Aggregation Strategy for Precise Cancer Diagnostics

Biotemplated precise assembly approach toward ultra-scaled high-performance electronics

Sensitive and automated detection of bacteria by CRISPR/Cas12a-assisted amplification with digital microfluidics

Integrated single-tube operation for rapid and uniform single-cell whole-genome sequencing

Microfluidic chip with reversible interface for noninvasive remission status monitoring and prognosis prediction of acute myeloid leukemia

Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins

Digital-scRRBS: A Cost-Effective, Highly Sensitive, and Automated Single-Cell Methylome Analysis Platform via Digital Microfluidics

Synergetic collision and space separation in microfluidic chip for efficient affinity-discriminated molecular selection

Integrated microfluidic devices for in vitro diagnostics at point of care

Decoding Expression Dynamics of Protein and Transcriptome at the Single-Cell Level in Paired Picoliter Chambers

Suppressing high-dimensional crystallographic defects for ultra-scaled DNA arrays

Antibody-engineered red blood cell interface for high-performance capture and release of circulating tumor cells

Well-Paired-Seq: A Size-Exclusion and Locally Quasi-Static Hydrodynamic Microwell Chip for Single-Cell RNA-Seq

A polypyrrole-mediated photothermal biosensor with a temperature and pressure dual readout for the detection of protein biomarkers

Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy

Single-Cell Digital Microfluidic Mass Spectrometry Platform for Efficient and Multiplex Genotyping of Circulating Tumor Cells

Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy

Magnetofluid-Integrated Multicolor Immunochip for Visual Analysis of Neutralizing Antibodies to SARS-CoV-2 Variants

Dissolution-Enhanced Luminescence Enhanced Digital Microfluidics Immunoassay for Sensitive and Automated Detection of H5N1

HIGHLY PARALLEL, RAPID, AND SENSITIVE SINGLE-CELL PROTEIN ANALYSIS WITH DIGITAL MICROFLUIDICS

MICROFLUIDIC CELL ASSEMBLY DEVICE FOR CELL-CELL INTERACTION AT THE SINGLE-CELL LEVEL

TARGETED SYNTHESIS OF BIOMIMETIC CELL WALL FOR CIRCULATING TUMOR CELL IDENTIFICATION AND PROTECTION

DYNAMIC MAGNETIC NANOMIXERS ENABLING RAPID ISOLATION AND MOLECULAR PROFILING OF TUMOR-DERIVED EXTRACELLULAR VESICLES

Interfacing droplet microfluidics with antibody barcodes for multiplexed single-cell protein secretion profiling

Auto-Panning: a highly integrated and automated biopanning platform for peptide screening

An electrochemical method for a rapid and sensitive immunoassay on digital microfluidics with integrated indium tin oxide electrodes coated on a PET film

Selection and applications of functional nucleic acids for infectious disease detection and prevention

A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection

Highly paralleled emulsion droplets for efficient isolation, amplification, and screening of cancer biomarker binding phages

Activation of Aptamers with Gain of Function by Small-Molecule-Clipping of Intramolecular Motifs

Nucleic Acids Analysis

In Situ Visualization of PD-L1-Specific Glycosylation on Tissue Sections

Stimulus-Responsive Microfluidic Interface Enables Efficient Enrichment and Cytogenetic Profiling of Circulating Myeloma Cells

HUNTER-Chip: Bioinspired Hierarchically Aptamer Structure-Based Circulating Fetal Cell Isolation for Non-Invasive Prenatal Testing

Sensitive, Rapid, and Automated Detection of DNA Methylation Based on Digital Microfluidics

In situ Raman enhancement strategy for highly sensitive and quantitative lateral flow assay

Dispen-Seq: a single-microparticle dispenser based strategy towards flexible cell barcoding for single-cell RNA sequencing

Digital-WGS: Automated, highly efficient whole-genome sequencing of single cells by digital microfluidics

Distance-based paper/PMMA integrated ELISA-chip for quantitative detection of immunoglobulin G

Stimuli-Responsive Microfluidic Interface Enables Highly Efficient Capture and Release of Circulating Fetal Cells for Non-Invasive Prenatal Testing

A Highly Sensitive, Accurate, and Automated Single-Cell RNA Sequencing Platform with Digital Microfluidics

DNA-directed nanofabrication of high-performance carbon nanotube field-effect transistors

Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method

Highly parallel and efficient single cell mRNA sequencing with paired picoliter chambers

Effects of Molecular Crowding on G-Quadruplex-hemin Mediated Peroxidase Activity

Trends in miniaturized biosensors for point-of-care testing

A Sequential Multidimensional Analysis Algorithm for Aptamer Identification based on Structure Analysis and Machine Learning

Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction

Highly Sensitive Minimal Residual Disease Detection by Biomimetic Multivalent Aptamer Nanoclimber Functionalized Microfluidic Chip

Crosstalk-free colloidosomes for high throughput single-molecule protein analysis

Aptamer Generated by Cell-SELEX for Specific Targeting of Human Glioma Cells

Tracing Tumor-Derived Exosomal PD-L1 by Dual-Aptamer Activated Proximity-Induced Droplet Digital PCR

Efficient Isolation and Phenotypic Profiling of Circulating Hepatocellular Carcinoma Cells via a Combinatorial-Antibody-Functionalized Microfluidic Synergetic-Chip

Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs

Catalase-linked immunosorbent pressure assay for portable quantitative analysis

Evolution of Nucleic Acid Aptamers Capable of Specifically Targeting Glioma Stem Cells via Cell-SELEX

Single cell transcriptomics: moving towards multi-omics

Stable Colloidosomes Formed by Self-Assembly of Colloidal Surfactant for Highly Robust Digital PCR

Bioinspired Engineering of a Multivalent Aptamer-Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells

Rapid, real-time chemiluminescent detection of DNA mutation based on digital microfluidics and pyrosequencing

Staining Traditional Colloidal Gold Test Strips with Pt Nanoshell Enables Quantitative Point-of-Care Testing with Simple and Portable Pressure Meter Readout

Visual Quantitative Detection of Circulating Tumor Cells with Single-Cell Sensitivity Using a Portable Microfluidic Device

Molecular Crowding Evolution for Enabling Discovery of Enthalpy-Driven Aptamers for Robust Biomedical Applications

Microfluidic Single-Cell Omics Analysis

Centrifugal-Driven Droplet Generation Method with Minimal Waste for Single-Cell Whole Genome Amplification

Isolation of circulating fetal trophoblast using fetal-chip for non-invasive prenatal diagnosis

An Allosteric-Probe for Detection of Alkaline Phosphatase Activity and Its Application in Immunoassay

Frequency-enhanced transferrin receptor antibody-labelled microfluidic chip (FETAL-Chip) enables efficient enrichment of circulating nucleated red blood cells for non-invasive prenatal diagnosis

Design and synthesis of ortho-phthalaldehyde phosphoramidite for single-step, rapid, efficient and chemoselective coupling of DNA with proteins under physiological conditions

Integrated paper-based microfluidic devices for point-of-care testing

A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami

DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells

In Situ Pt Staining Method for Simple, Stable, and Sensitive Pressure-Based Bioassays

Highly Sensitive and Automated Surface Enhanced Raman Scattering-based Immunoassay for H5N1 Detection with Digital Microfluidics

Target-responsive DNA hydrogel for nonenzymatic and visual detection of glucose

Facile fabrication of microfluidic surface-enhanced Raman scattering devices via lift-up lithography

Lateral flow assay with pressure meter readout for rapid point-of-care detection of disease-associated protein

Gas-generating reactions for point-of-care testing

Microwell Array Method for Rapid Generation of Uniform Agarose Droplets and Beads for Single Molecule Analysis

Recent Progress in Microfluidics-Based Biosensing

An automated binding ligand affinity evaluation platform using digital microfluidics

Detection of T4 Polynucleotide Kinase via Allosteric Aptamer Probe Platform

Centrifugal micropipette-tip with pressure signal readout for portable quantitative detection of myoglobin

Selection and identification of transferrin receptor-specific peptides as recognition probes for cancer cells

A fully integrated distance readout ELISA-Chip for point-of-care testing with sample-in-answer-out capability

Integrated Distance-Based Origami Paper Analytical Device for One-Step Visualized Analysis

Isolation, Detection, and Antigen-Based Profiling of Circulating Tumor Cells Using a Size-Dictated Immunocapture Chip

Integrating Target-Responsive Hydrogel with Pressuremeter Readout Enables Simple, Sensitive, User-Friendly, Quantitative Point-of-Care Testing

A portable visual detection method based on a target-responsive DNA hydrogel and color change of gold nanorods

Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis

Enrichment and single-cell analysis of circulating tumor cells

Design and synthesis of target-responsive hydrogel for portable visual quantitative detection of uranium with a microfluidic distance-based readout device

Target-responsive DNAzyme hydrogel for portable colorimetric detection of lanthanide(III) ions

Afi-chip: An equipment-free, low-cost, and universal binding ligand affinity evaluation platform

Surface-Enhanced Raman Scattering Active Plasmonic Nanoparticles with Ultrasmall Interior Nanogap for Multiplex Quantitative Detection and Cancer Cell Imaging

Evolution of DNA aptamers for malignant brain tumor gliosarcoma cell recognition and clinical tissue imaging

Enzyme-Encapsulated Liposome-Linked Immunosorbent Assay Enabling Sensitive Personal Glucose Meter Readout for Portable Detection of Disease Biomarkers

Integration of target responsive hydrogel with cascaded enzymatic reactions and microfluidic paper-based analytic devices (μPADs) for point-of-care testing (POCT)

Distance-based microfluidic quantitative detection methods for point-of-care testing

Advance in phage display technology for bioanalysis

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

DNA-Mediated Morphological Control of Silver Nanoparticles

Recent Progress in Aptamer-Based Functional Probes for Bioanalysis and Biomedicine

A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein

Detection of DNA methyltransferase activity using allosteric molecular beacons

Selection and Application of DNA Aptamer Against Oncogene Amplified in Breast Cancer 1

Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis

Simple and Rapid Functionalization of Gold Nanorods with Oligonucleotides Using an mPEG-SH/Tween 20-Assisted Approach

Stable DNA Nanomachine Based on Duplex-Triplex Transition for Ratiometric Imaging Instantaneous pH Changes in Living Cells

Evolution of DNA aptamers through in vitro metastatic-cell-based systematic evolution of ligands by exponential enrichment for metastatic cancer recognition and imaging

Target-responsive DNA hydrogel mediated stop-flow microfluidic paper-based analytic device for rapid, portable and visual detection of multiple targets

Design and synthesis of target-responsive aptamer-cross-linked hydrogel for visual quantitative detection of ochratoxin A

A label-free fluorescence strategy for sensitive detection of ATP based on the ligation-triggered super-sandwich

Target-responsive DNAzyme cross-linked hydrogel for visual quantitative detection of lead

Au@pt nanoparticle encapsulated target-responsive hydrogel with volumetric bar-chart chip readout for quantitative point-of-care testing

Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions

A cell-surface-anchored ratiometric fluorescent probe for extracellular pH sensing

Label-free fluorescence strategy for sensitive detection of adenosine triphosphate using a loop DNA probe with low background noise

In Vitro Selection of DNA Aptamers for Metastatic Breast Cancer Cell Recognition and Tissue Imaging

Microfluidic approaches to rapid and efficient aptamer selection

Monoclonal Surface Display SELEX for Simple, Rapid, Efficient, and Cost-Effective Aptamer Enrichment and Identification

Facile and Rapid Generation of Large-Scale Microcollagen Gel Array for Long-Term Single-Cell 3D Culture and Cell Proliferation Heterogeneity Analysis

In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier

A highly parallel microfluidic droplet method enabling single-molecule counting for digital enzyme detection

A T7 exonuclease-assisted cyclic enzymatic amplification method coupled with rolling circle amplification: a dual-amplification strategy for sensitive and selective microRNA detection

Carbon nanoparticle-protected aptamers for highly sensitive and selective detection of biomolecules based on nuclease-assisted target recycling signal amplification

A diazirine-based photoaffinity probe for facile and efficient aptamer-protein covalent conjugation

A multifunctional nanomicelle for real-time targeted imaging and precise near-infrared cancer therapy

Graphene oxide protected nucleic acid probes for bioanalysis and biomedicine

Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture

Engineering a cell-surface aptamer circuit for targeted and amplified photodynamic cancer therapy

An electrochemical sensor based on label-free functional allosteric molecular beacons for detection target DNA/miRNA

Target-responsive "sweet" hydrogel with glucometer readout for portable and quantitative detection of non-glucose targets

Stabilization of ssRNA on Graphene Oxide Surface: An Effective Way to Design Highly Robust RNA Probes

DNA micelle flares for intracellular mrna imaging and gene therapy

Single-molecule photon-fueled DNA nanoscissors for DNA cleavage based on the regulation of substrate binding affinity by azobenzene

Backbone-modified molecular beacons for highly sensitive and selective detection of microRNAs based on duplex specific nuclease signal amplification

Cyclic enzymatic amplification method (CEAM) based on exonuclease III for highly sensitive bioanalysis

A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer-Protein Interactions

L -DNA molecular beacon: A safe, stable, and accurate intracellular nano-thermometer for temperature sensing in living cells

Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity

In vitro selection of highly efficient G-quadruplex-based DNAzymes

Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2

Single-molecule force spectroscopic studies on intra- and intermolecular interactions of G-quadruplex aptamer with target Shp2 protein

Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples

Single-molecule emulsion PCR in microfluidic droplets

Massively parallel single-molecule and single-cell emulsion reverse transcription polymerase chain reaction using agarose droplet microfluidics

Highly parallel single-molecule amplification approach based on agarose droplet polymerase chain reaction for efficient and cost-effective aptamer selection

Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level

Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme

Caged molecular beacons: controlling nucleic acid hybridization with light