英文论文
-
文献类型
-
Article
-
题名
-
Pattern of multiple human papillomavirus infection and type competition: An analysis in healthy Chinese women aged 18-45 years
-
作者
-
Su, Yingying; Zheng, Tingquan; Bi, Zhaofeng; Jia, Xinhua; Li, Yufei; Kuang, Xuefeng; Yang, Yuan; Chen, Qi; Lin, Hongyan; Huang, Yue; Huang, Shoujie; Qiao, Youlin; Wu, Ting; Zhang, Jun; Xia, Ningshao
-
作者单位
-
[Su, Yingying; Zheng, Tingquan; Bi, Zhaofeng; Jia, Xinhua; Li, Yufei; Kuang, Xuefeng; Yang, Yuan; Chen, Qi; Lin, Hongyan; Huang, Yue; Huang, Shoujie; Wu, Ting; Zhang, Jun; Xia, Ningshao] Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiang Biomed Lab, Xiamen, Peoples R China. [Su, Yingying; Zheng, Tingquan; Bi, Zhaofeng; Jia, Xinhua; Li, Yufei; Kuang, Xuefeng; Yang, Yuan; Chen, Qi; Lin, Hongyan; Huang, Yue; Huang, Shoujie; Wu, Ting; Zhang, Jun; Xia, Ningshao] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, NMPA Key Lab Res & Evaluat Infect Dis Diagnost Tec, Xiamen, Peoples R China. [Jia, Xinhua; Li, Yufei; Kuang, Xuefeng; Yang, Yuan; Qiao, Youlin] Chinese Acad Med Sci, Canc Inst, Peking Union Med Coll, Natl Canc Ctr,Natl Ctr Canc Clin Res, Beijing, Peoples R China. [Su, Yingying] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, Sch Publ Hlth, State Key Lab Vaccines Infect Dis,NMPA Key Lab Res, Xiamen 361102, Peoples R China.
-
通讯作者地址
-
Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, Sch Publ Hlth, State Key Lab Vaccines Infect Dis,NMPA Key Lab Res, Xiamen 361102, Peoples R China.
-
Email
-
yingyingsu@xmu.edu.cn
-
ResearchID
-
-
ORCID
-
-
期刊名称
-
HUMAN VACCINES & IMMUNOTHERAPEUTICS
-
出版社
-
TAYLOR & FRANCIS INC
-
ISSN
-
2164-5515
-
出版信息
-
2024-12-31, 20 (1)
-
JCR
-
-
影响因子
-
-
ISBN
-
-
基金
-
National Natural Science Foundation of China [82072323, 82273640]; Natural Science Foundation of Fujian Province [2020J01044]; CAMS Innovation Fund for Medical Sciences of China [2019RU022]; Fundamental Research Funds for the Central Universities [20720220006, 20720200105]
-
会议名称
-
-
会议地点
-
-
会议开始日期
-
-
会议结束日期
-
-
关键词
-
HPV; multiple infection; type competition; type replacement; postvaccination
-
摘要
-
To assess the pattern of multiple human papillomavirus infection to predict the type replacement postvaccination. A total of 7372 women aged 18-45y from a phase III trial of an Escherichia coli-produced HPV-16/18 vaccine were analyzed at enrollment visit before vaccination. Hierarchical multilevel logistic regression was used to evaluate HPV vaccine type and nonvaccine-type interactions with age as a covariate. Binary logistic regression was construed to compare multiple infections with single infections to explore the impact of multiple-type infections on the risk of cervical disease. Multiple HPV infections were observed in 25.2% of HPV-positive women and multiple infections were higher than expected by chance. Statistically significant negative associations were observed between HPV16 and 52, HPV18 and HPV51/52/58, HPV31 and HPV39/51/52/53/54/58, HPV33 and HPV52/58, HPV58 and HPV52, HPV6 and HPV 39/51/52/53/54/56/58. Multiple HPV infections increased the risk of CIN2+ and HSIL+, with the ORs of 2.27(95%CI: 1.41, 3.64) and 2.26 (95%CI: 1.29, 3.95) for multiple oncogenic HPV infection separately. However, no significant evidence for the type-type interactions on risk of CIN2+ or HSIL+. There is possibility of type replacement between several pairs of vaccine and nonvaccine HPV type. Multiple HPV infection increased the risk of cervical disease, but coinfection HPV types seem to follow independent disease processes. Continued post-vaccination surveillance for HPV 51/52/58 types and HPV 39/51 types separately was essential after the first and second generation of HPV vaccination implementation in China.
-
一级学科
-
Biotechnology & Applied Microbiology; Immunology
-
WOS入藏号
-
WOS:001203012500001
-
EI收录号
-
-
DOI
-
10.1080/21645515.2024.2334474
-
ESI
-
-
收录于
-
SCIE
-
返回