英文论文
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文献类型
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Journal article (JA)
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题名
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Subacute exposure to black phosphorus quantum dots induces cardiac fibrosis and the potential role of gut microbiota
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作者
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Han, Jianrong; Ruan, Fengkai; Yang, Chunyan; Zuo, Zhenghong; Liu, Zonghong; He, Chengyong
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作者单位
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[Han, Jianrong; Ruan, Fengkai; Yang, Chunyan; Zuo, Zhenghong; He, Chengyong] Xiamen Univ, Sch Life Sci, Fac Med & Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China. [Zuo, Zhenghong; Liu, Zonghong; He, Chengyong] Xiamen Univ, Xiangan Hosp, Dept Cardiovasc Surg, Xiamen 361102, Peoples R China.
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通讯作者地址
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Xiamen Univ, Sch Life Sci, Fac Med & Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China.; Xiamen Univ, Xiangan Hosp, Dept Cardiovasc Surg, Xiamen 361102, Peoples R China.
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Email
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liuzonghong@163.com; hecy@xmu.edu.cn
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ResearchID
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ORCID
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期刊名称
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Journal of Environmental Sciences (China)
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出版社
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SCIENCE PRESS
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ISSN
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1001-0742
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出版信息
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2025-06, 152 ():167-177.
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JCR
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影响因子
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ISBN
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基金
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National Natural Science Foundation of China [22376174]; Natural Science Foundation of Xiamen Municipality [2022FCX012503010342]
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会议名称
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会议地点
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会议开始日期
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会议结束日期
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关键词
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Mammals; Nanocrystals; Phosphorus; Semiconductor quantum dots
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摘要
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Black phosphorus quantum dots (BPQDs) have been used as the nano-carrier in the field of biomedicine due to their excellent electronic conductivity, optical and thermoelectric properties. However, it is still lack of evaluation of the safety of BPQDs, specifically on the effects and mechanisms of BPQDs on heart. In this study, the specific pathogen-free male mice were orally administered with different doses of BPQDs (0.02, 0.1, 0.5 mg/kg) for 28 days. BPQDs exposure decreased the heart-body ratio and caused cardiac hypertrophy and fibrosis. Additionally, ferroptosis was observed in the cardiac tissue. The recent study has shown BPQDs oral exposure alter gut microbiota. Here, after exposure to 0.1 mg/kg BPQDs for 28 days, the germ-free mice showed neither cardiac injury nor ferroptosis. Taken together, the study demonstrates that BPQDs induce cardiac ferroptosis and fibrosis, possibly mediated by gut microbiota. This research may aid in enhancing understanding of the biosafety of BP nanomaterials and promoting the sustainable development of nanotechnology. (c) 2024 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
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一级学科
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Environmental Sciences
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WOS入藏号
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WOS:001244549800001
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EI收录号
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20242016100901
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DOI
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10.1016/j.jes.2024.03.049
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ESI
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收录于
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SCIE, EI
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